期刊文献+
共找到10篇文章
< 1 >
每页显示 20 50 100
The Secret Toxic Legacies of Chemical Warfare: Agent Blue Use during the 2nd Indochina and Vietnam Wars in Laos, Cambodia, and Vietnam (1961 to 1971)
1
作者 Kenneth R. Olson 《Open Journal of Soil Science》 2024年第11期689-725,共37页
During the 2nd Indochina War which started in 1959, the United States Central Intelligence Agency (CIA), Air America, and the Air Force waged a secret and unconventional air war in Laos from Udorn Air Force base locat... During the 2nd Indochina War which started in 1959, the United States Central Intelligence Agency (CIA), Air America, and the Air Force waged a secret and unconventional air war in Laos from Udorn Air Force base located in Thailand and across the Mekong River from Vientiane, Laos. Starting in 1961, four years before the official start of the American-Vietnam War, Agent Blue, the arsenic-based herbicide used to kill rice and other food crops, was used extensively in Laos, Vietnam and to a lesser extent in Cambodia. During the secret 2nd Indochina War and the Vietnam Civil War the public knew little about the use of Agent Blue. After the official start of the American-Vietnam War in 1965, the United States media news reports, about chemical warfare were dominated by the story of Agent Orange and its devastating impacts. The public knew very little about the previous use of Agent Blue in both wars. The first known media pick up of the Agent Blue (arsenic based) and Agent Pink, Agent Green, and Agent Purple (all three contain 2, 4, 5-T and unknown amounts of dioxin TCDD) was in May of 1964. Jim G. Lucas, a Scripps-Howard staff reporter submitted an article that was published as an editorial in Washington Post on May 26, 1964. The next news reference to this chemical weapon was a Letter to the Editor published in the New York Times titled “Agent Blue” in Vietnam by Arthur H. Westing in (1971). The use of herbicides, including Agent Blue in Laos during the 2nd Indochina War, was kept a secret until 1982, when a draft of Buckingham’s study of Operation Ranch Hand was made public. Much about the U.S. war effort in Laos is still classified. In a 2014 issue of the VVA Veteran magazine, Loana Hoylman published an article on “Today’s Blue Arsenic in the Environment”. The first refereed journal article on this topic, “The Fate of Agent Blue, the Arsenic-Based Herbicide, Used in South Vietnam during the Vietnam War” was published in 2020 in the Open Journal of Soil Science by Kenneth R. Olson and Larry Cihacek. 展开更多
关键词 Laos VIETNAM 2nd Indochina War Vietnam War Agent Blue Arsenic cacodylic acid
下载PDF
How United States Agricultural Herbicides Became Military and Environmental Chemical Weapons: Historical and Residual Effects 被引量:1
2
作者 Kenneth R. Olson Larry Cihacek 《Open Journal of Soil Science》 2022年第2期13-81,共69页
Discoveries in Charles Darwin’s laboratory led to modern herbicides. Darwin discovered the internal mechanism that directed plants to grow toward sunlight and sources of water. Scientists in Europe and America later ... Discoveries in Charles Darwin’s laboratory led to modern herbicides. Darwin discovered the internal mechanism that directed plants to grow toward sunlight and sources of water. Scientists in Europe and America later called this mechanism a plant’s hormone response system. Administrators and scientists, including Dr. Ezra J. Kraus, the Head of the Botany Department at the University of Chicago and a plant physiologist, suggested on the eve of WWII that weed killers had significant military value as chemical weapons. Dr. Kraus obtained access to a synthetic chemical, 2,4-D, and found that when the chemical was absorbed through the leaves of plants, it destroyed a plant’s hormones. After exposure, the plant experienced rapid and uncontrolled growth, and then the leaves shriveled, died and fell off. Dr. Kraus obtained funding for his Department of Botany research program from Department of Defense (DOD) during World War II (WWII). Camp Detrick (Biological Weapons Laboratory) scientists later obtained samples of newly created 2,4,5-T which contained unknown amounts of the by-product dioxin TCDD. In the 1950s and 1960s, Fort Detrick military scientists formulated the herbicide Agent Orange, which was a 50 - 50 mixture of 2,4-D and 2,4,5-T. These dual purpose herbicides were used by DOD and USDA. American and European farmers in the 1940s used 2,4-D and 2,4,5-T to eliminate weeds from pastureland and cropland. After WWII, synthetic herbicides (and pesticides) development continued in tandem with production of synthetic fertilizers and breeding of high-yield plant varieties. These new agricultural products were then shipped worldwide to increase crop yields, as part of the Green Revolution. This new system of agricultural technologies was intended to eliminate global starvation and increase food security by increasing field and farm crop yields. In contrast, the goal of military use of herbicides, as chemical weapons, was to defoliate jungle forests and destroy food crops as a strategy to win battles and wars. The 展开更多
关键词 Agent Orange Agent Blue Dioxin TCDD cacodylic acid Arsenic Environmental Weapons Chemical Weapons Ecocide TIBA 2 4-D 2 4 5 -T Ezra J. Kraus Arthur W. Galston Green Revolution Agricultural Herbicides
下载PDF
Agent Blue Spraying in the Mekong Delta during the Vietnam War: Fate of the Arsenic Based Herbicide Weapon Used to Destroy Rice Crop and Mangrove Forests 被引量:1
3
作者 Kenneth R. Olson Larry Cihacek 《Open Journal of Soil Science》 CAS 2022年第7期253-294,共42页
Agent Blue, a mixture of cacodylic acid (CH<sub>3</sub>) As O<sub>2</sub>H) and sodium cacodylate (C<sub>2</sub>H<sub>6</sub> AsNaO<sub>2</sub>), was a tacti... Agent Blue, a mixture of cacodylic acid (CH<sub>3</sub>) As O<sub>2</sub>H) and sodium cacodylate (C<sub>2</sub>H<sub>6</sub> AsNaO<sub>2</sub>), was a tactical arsenic-based herbicide used during the Vietnam War to destroy grasses and rice crops. Natural and synthetic sources of arsenic can degrade into water-soluble forms and persist in groundwater and potentially contribute to elevating As levels in drinking water. The United States Department of Defense (DOD) and United States Department of Agricultural (USDA) Operation Ranch Hand records for tactical herbicides including Agent Blue sprayed in southern Vietnam during the Vietnam War (1961-1971) are very detailed, rather complete and publicly available. The same is not true for tactical herbicides sprayed by the Republic of Vietnam (RV) during the Khai Quang program which was supported by the U.S. Army, U.S. Navy and Central Intelligence Agency (CIA) in the Mekong Delta. Agent Blue was sprayed by the RV military for three years before the official start of the American-Vietnam War. Few, if any, RV military, US Army, US Navy and CIA spray records exist from 1962 to 1965. Vietnam War veterans, historians and scholars have reported the spraying of 3.2 million liters (468,008 kg As) of Agent Blue on rice paddies and mangrove forests in the Mekong Delta and Central Highlands by the RV military with the support of the US Army, US Navy and CIA. The Institute of Medicine estimated that 3.2 million liters (468,000 kg As) were sprayed during the RV Khai Quang program. This was in addition to the U.S. Air Force’s Operation Ranch Hand spraying of the tactical herbicide Agent Blue primarily by C-123 aircraft. The Operation Ranch Hand missions maintained location and quantities of herbicides sprayed (over 4,712,000 liters (664,392 kg As) from 1961-1971. The RV military and US military (Army and Navy) spray equipment included hand and backpack sprayers, sprayers mounted on Brown Water Navy boats, on Army track vehicles and Army land-based helicopters and helicopters based 展开更多
关键词 Operation Ranch Hand Khai Quang program Agent Blue ARSENIC cacodylic acid North Vietnam Army Republic of Vietnam Democratic Republic of Vietnam American-Vietnam War
下载PDF
Agent Blue: A Secret Military and Environmental Chemical Weapon Used for Food Denial in South Vietnam during the Vietnam Civil War (1962-1965)
4
作者 Kenneth R. Olson 《Open Journal of Soil Science》 2023年第3期151-186,共21页
During the last 60 years, the southern Vietnam environment and Vietnamese living in the Mekong Delta have bio-accumulated arsenic from natural and anthropic (Vietnam Civil War (1962-1965)) sources via their drinking w... During the last 60 years, the southern Vietnam environment and Vietnamese living in the Mekong Delta have bio-accumulated arsenic from natural and anthropic (Vietnam Civil War (1962-1965)) sources via their drinking water (groundwater from tube wells) and food supply leading to an increasing risk of chronic poisoning over time. A synthesis and analysis of publications and records is presented to document the Republic of Vietnam (RV), the official name of the South Vietnam Government, and United States (US) militaries contribution to arsenic levels and toxic spikes in the Vietnam Mekong Delta groundwater. During the Vietnam Civil War, Agent Blue, in powder form, was shipped to Port Saigon, via the Saigon River, and transported to the Tan Son Nhut Air Force base during the Vietnam Civil War. After the official start of the American-Vietnam War (1965-1973) the tactical herbicides were re-routed to Bien Hoa Air Force base (1965 to 1971). Approximately 3.2 million liters of Agent Blue (468,008 kg As) was sprayed or dumped by the RV military with the assistance and support of the Central Intelligence (CIA), US Army and US Navy, during the 1962-1965 Khai Huang (Hamlet) Program. A portion of an additional 4.6 million liters of Agent Blue (664,392 kg of As) was sprayed between 1962 and 1965 by the US Air Force as part of Operation Ranch Hand and prior to the official start of the American-Vietnam War in August 1964. Operation Rand Hand began in 1962 and ended in 1971. The Institute of Medicine estimated a total of 7.8 million liters (1,132,400 kg As) of Agent Blue was applied to southern Vietnam landscape from 1962 to 1971. This total includes both the 1962 to 1965 RV Khai Huang program with the assistance of the CIA, US Army and US Navy, and the total Agent Blue applied by US Air Force Operation Ranch Hand from 1962 to 1971. The primary objective of this study was to document how Agent Blue, the arsenic-based herbicide, became a secret US military and environmental chemical weapon used by the RV and US militaries in sout 展开更多
关键词 Arsenic cacodylic acid Agent Blue Herbicides Chemical Weapons Fort Detrick Department of Defense (DOD) President Kennedy President Diem CIA US State Department USDA Khai Huang
下载PDF
Review and Analysis: Fate of Arsenic Applied to Canal Shipping Lane Vegetation and United States Military Base Grounds in the Panama Canal Zone
5
作者 Kenneth R. Olson 《Open Journal of Soil Science》 2023年第10期391-413,共23页
The opening of the Panama Canal in 1913 increased the availability of internationally traded goods and transformed ocean-shipping by shortening travel time between the Atlantic Ocean and Pacific Ocean. The canal spark... The opening of the Panama Canal in 1913 increased the availability of internationally traded goods and transformed ocean-shipping by shortening travel time between the Atlantic Ocean and Pacific Ocean. The canal sparked the growth of port authorities and increased ship tonnage on both coasts of Panama. Since the construction of the Panama Canal, in the 1910s, pesticides, herbicides and chemicals, including arsenic, have been essential for controlling wetland vegetation, including hyacinth, which blocked rivers, lakes, and the canal as well as managing mosquitoes. Pesticides and chemicals flowed into Lake Gatun (reservoir) either attached to sediment or in solution during the monsoon season. Lake Gatun was the drinking water source for most of the people living in the Panama Canal Zone. The United States military base commanders had the ability to order and use cacodylic acid (arsenic based) from the Naval Depot Supply Federal and Stock Catalog and the later Federal Supply Catalog on the military base grounds in the Panama Canal Zone. Cacodylic acid was shipped to Panama Canal Zone ports, including Balboa and Cristobal, and distributed to the military bases by rail or truck. The objective of this study is to determine the fate of arsenic: 1) applied between 1914 and 1935 to Panama Canal shipping lane hyacinth and other wetland vegetation and 2) cacodylic acid (arsenic) sprayed from 1948 to 1999 on the US military base grounds in the Panama Canal Zone. 展开更多
关键词 Panama Canal ARSENIC Hyacinth Lake Gatun Shipping Lanes cacodylic acid
下载PDF
Agent Orange Chemical Plant Locations in the United States and Canada: Environmental and Human Health Impacts
6
作者 Kenneth R. Olson David R. Speidel 《Open Journal of Soil Science》 CAS 2022年第8期363-426,共64页
During the Vietnam War, millions of liters of six tactical herbicides were sprayed on the southern Vietnam landscape to defoliate forests, to clear military perimeters and to destroy enemy food supplies. The environme... During the Vietnam War, millions of liters of six tactical herbicides were sprayed on the southern Vietnam landscape to defoliate forests, to clear military perimeters and to destroy enemy food supplies. The environmental and human health impacts of spraying these herbicides, especially Agent Orange and those formulated with mixtures that included 2,4,5-trichlorophenoxyacetic acid (2,4,5-T) which was contaminated with 2,3,7,8-tetracholorodibenzo-p-dioxin (TCDD) have been documented over the last 60 years. The dioxin TCDD clean-up efforts at former military bases and other Vietnam hotspots are ongoing. However, the lesser-told story was the environmental and human health impacts on the communities and chemical plant workers who manufactured Agent Orange and other herbicides that became contaminated with dioxin TCDD in the manufacturing processes at seven locations in the United States and one site in Canada. The pollution at these chemical plant sites, adjacent rivers and groundwater is well known within each affected state or province but not widely recognized beyond their localities. In this paper we assess the national long-term effects on land, groundwater and river resources where Agent Orange and other agricultural herbicides containing 2,4,5-T with unknown amounts of dioxin TCDD were manufactured, transported, and temporarily stored. The sites where residual tactical herbicides with contaminated by-products were applied to public lands or disposed of by military and civilian workers within the United States and Canada are identified. After 60 years, these communities are still paying the price for the U.S. Government, DOD and USDA decisions to provide and use agricultural herbicides as tactical chemical weapons during the Vietnam War (1962-1971). There have been human health issues associated with the chemical manufacture, transport, storage and disposal of these herbicides related to workers who moved these chemical weapons from United States and Canada to SE Asia. Most of these dioxin contaminated tactica 展开更多
关键词 Dioxin TCDD Arsenic Chemical Plant Workers CHLORACNE Cancer Herbicides cacodylic acid Monsanto Dow Nitro Midland Elmira Uniroyal Times Beach MISSOURI Gagetown Incineration Certified Landfill Environmental Covenants
下载PDF
Natural and Anthropic Sources of Arsenic in the Groundwater and Soils of the Mekong Delta
7
作者 Kenneth R. Olson Khoi Minh Chau 《Open Journal of Soil Science》 CAS 2022年第11期541-570,共30页
Human exposure to arsenic (As) is primarily through drinking water and food ingestion. Arsenic is naturally present in the environment and has been known as “the king of poisons” since the Middle Ages. It is mutagen... Human exposure to arsenic (As) is primarily through drinking water and food ingestion. Arsenic is naturally present in the environment and has been known as “the king of poisons” since the Middle Ages. It is mutagenic, teratogenic, and carcinogenic and approximately 70% comes from ingested food and 29% from water. Once ingested, arsenic can bio-accumulate in the human body or be excreted. Arsenic in groundwater is a main source of As in humans and the two arsenicals most abundant in water are arsenite (+3 oxidation state) and arsenate (+5 oxidation state). In order of toxicity from the most toxic to least toxic are arsines, arsenites, arsenoxides, arsenates, pentavalent arsenicals, Arsenic compounds, and metallic arsenic. Arsenic accumulates in the body when ingested in small doses. It often takes decades before physical symptoms of As poisoning show. While As is element normally found in the human body, it is highly toxic in excess amounts. The lethal dose for rates is 48 μg/L which translates to 125 mg for a middle-aged male. The maximum safe limit for As ingestion for an average Vietnamese middle-aged male is 220 μg per day. This lethal dosage puts As in a highly toxic category in food and toxicology. Most of the As in the Mekong Delta groundwater is from natural alluvial sediment sources. Other anthropic sources include the burial of millions of Vietnamese with elevated As levels since 1962, industrial sources, smelting by-products, water treatment plants, sewage and wastewater treatment discharges into waterways have added to the Mekong Delta As levels in the soil and groundwater. However, Agent Blue, the As-based herbicide, used during the Vietnam War, did contribute a significant amount (over 1,132,400 kg of manufactured (anthropic) As) to Southern Vietnam landscape. The As spikes and levels in the Mekong Delta soils and groundwater need restoration. The uptake of trace amounts of As in rice is indeed a critical food security and human health issue and requires mitigation. 展开更多
关键词 ARSENIC Mekong Delta Anthropic Arsenic Agent Blue Khai Hoang cacodylic acid Water Treatment Plants
下载PDF
二甲基胂酸促小鼠肺和皮肤肿瘤发生与诱发氧化应激 被引量:1
8
作者 安艳 银华 +4 位作者 李贞 王三祥 王正辉 韩步麟 孔献珍 《中国地方病学杂志》 CAS CSCD 北大核心 2009年第1期10-13,共4页
目的观察二甲基胂酸(DMA^v)对小鼠肺和皮肤肿瘤的促进作用与二甲基次胂酸(DMA^v)诱发氧化应激之间的关系。方法利用4-硝基喹啉-1~氧化物(4NQO)作为始动剂、DMA。作为促进剂的致小鼠肺肿瘤两阶段动物模型,并给予L-(-)-表没食... 目的观察二甲基胂酸(DMA^v)对小鼠肺和皮肤肿瘤的促进作用与二甲基次胂酸(DMA^v)诱发氧化应激之间的关系。方法利用4-硝基喹啉-1~氧化物(4NQO)作为始动剂、DMA。作为促进剂的致小鼠肺肿瘤两阶段动物模型,并给予L-(-)-表没食子儿茶素没食子酸酯(EGCG)干预,以及用7,12二甲基苯并蒽(DMBA)作为始动剂、DMAm作为促进剂的致小鼠皮肤肿瘤两阶段动物模型,观察肿瘤发生情况并对皮肤肿瘤进行病理分析:用高效液相色谱法测量小鼠肺和皮肤中8-氧-2’-脱氧鸟嘌呤核苷(8-oxodG)变化。结果小鼠发生肿瘤数和肺组织8-oxodG水平.4NQO+DMA。+EGCG组明显低于4NQO+DMA、组(0.89±0.30比4.00±0.82,1.21±0.09比1.53±0.32;P〈0.01)。DMBA+DMI。组小鼠皮肤高度角化发生数高于DMBA组(25比10,P〈0.05);与0h[(1.25±0.11)/10^5dG]比较,表皮组织8-oxodG的生成量0.5h[(1.67±0.17)/105dG]、1.0hf(1.62±0.12)/105dG]、2.0hf(1.66-±0.23)/10^5dG]、3.0h[(1.60±O.15)/10^5dG]明显增多(P〈0.01)。结论DMAv的促肿瘤发生作用与DMAm诱发的氧化应激密切相关。 展开更多
关键词 二甲胂酸 氧化性应激 肿瘤 二甲基次胂酸 L-(-)-表没食子儿茶素没食子酸酯
原文传递
二甲胂酸对人皮肤成纤维细胞DNA的损伤作用及缝隙连接通讯的影响 被引量:2
9
作者 邓芙蓉 金昱 +2 位作者 王慧 李新华 郭新彪 《北京大学学报(医学版)》 CAS CSCD 北大核心 2001年第6期497-500,共4页
目的 :研究二甲胂酸对人皮肤成纤维细胞DNA的损伤作用及细胞缝隙连接通讯的影响。方法 :分别采用单细胞凝胶电泳技术和细胞划痕染料标记示踪技术检测二甲胂酸对人皮肤成纤维细胞DNA的损伤作用及细胞缝隙连接通讯的影响。结果 :浓度为 0 ... 目的 :研究二甲胂酸对人皮肤成纤维细胞DNA的损伤作用及细胞缝隙连接通讯的影响。方法 :分别采用单细胞凝胶电泳技术和细胞划痕染料标记示踪技术检测二甲胂酸对人皮肤成纤维细胞DNA的损伤作用及细胞缝隙连接通讯的影响。结果 :浓度为 0 .0 1~ 1.0mmol·L-1的二甲胂酸对人皮肤成纤维细胞的DNA损伤作用较强 ,出现较多的DNA断裂。 1.0mmol·L-1的二甲胂酸还可明显抑制细胞缝隙连接通讯 ,提示二甲胂酸可能有促癌活性。结论 :二甲胂酸的遗传毒性较强 ,同时二甲胂酸可能有促癌活性。 展开更多
关键词 二甲胂酸 药理学 DNA损伤 药物作用 细胞交流 细胞间接合部
下载PDF
二甲胂酸诱导胃癌细胞SGC-7901凋亡的研究
10
作者 于雅晴 汪成富 +3 位作者 陈军 张高川 成中芹 赵志东 《实用肿瘤杂志》 CAS 2006年第4期305-308,共4页
目的探讨二甲胂酸(DMAA)诱导胃癌细胞SGC-7901的凋亡作用。方法用不同浓度的二甲胂酸与人的胃癌细胞SGC-7901共育一段时间后观察细胞的存活、形态学改变及生物学变化。结果其中以0.5~5.0mmol/L浓度的DMAA诱导其凋亡的作用最明显... 目的探讨二甲胂酸(DMAA)诱导胃癌细胞SGC-7901的凋亡作用。方法用不同浓度的二甲胂酸与人的胃癌细胞SGC-7901共育一段时间后观察细胞的存活、形态学改变及生物学变化。结果其中以0.5~5.0mmol/L浓度的DMAA诱导其凋亡的作用最明显。主要形态学表现为细胞膜完整、染色质固缩、核碎裂、凋亡小体形成;电泳结果上则显示明显的梯形凋亡条带。而当DMAA浓度≥10mmol/L时细胞核和细胞质中的荧光减弱,细胞呈坏死趋势;同时,MTT结果显示随着DMAA浓度的升高,细胞的活性明显降低。结论DMAA在低浓度时能有效诱导胃癌细胞SGC-7901凋亡,而高浓度时主要导致其坏死。 展开更多
关键词 二甲胂酸/药理学 胃肿瘤/病理学 细胞凋亡 肿瘤细胞 培养的
下载PDF
上一页 1 下一页 到第
使用帮助 返回顶部