This review summarizes recent progress in developing wireless,batteryless,fully implantable biomedical devices for real-time continuous physiological signal monitoring,focusing on advancing human health care.Design co...This review summarizes recent progress in developing wireless,batteryless,fully implantable biomedical devices for real-time continuous physiological signal monitoring,focusing on advancing human health care.Design considerations,such as biological constraints,energy sourcing,and wireless communication,are discussed in achieving the desired performance of the devices and enhanced interface with human tissues.In addition,we review the recent achievements in materials used for developing implantable systems,emphasizing their importance in achieving multi-functionalities,biocompatibility,and hemocompatibility.The wireless,batteryless devices offer minimally invasive device insertion to the body,enabling portable health monitoring and advanced disease diagnosis.Lastly,we summarize the most recent practical applications of advanced implantable devices for human health care,highlighting their potential for immediate commercialization and clinical uses.展开更多
In various biomedical fields,noninvasive medical procedures are favored over invasive techniques,as the latter require major incisions or surgeries that cause bleeding,pain,and tissue scarring.The increased use of non...In various biomedical fields,noninvasive medical procedures are favored over invasive techniques,as the latter require major incisions or surgeries that cause bleeding,pain,and tissue scarring.The increased use of noninvasive biomedical equipment has created a demand for effective energy storage devices that are sufficiently compact to be used as a power source,easy to commercialize,and bio-friendly.Herein,we report the facile synthesis of nickel molybdenum oxide nanoparticle-infused biocarbon microfibers(NiMoO NPs@BCMFs)as a novel energy storage material.The microfibers were derived from the bracket fungus Laetiporus sulphureus.In a three-electrode system,the NiMoO NPs@BCMFs/nickel foam(NF)electrode delivered an areal capacity of 113µAh cm^(-2)at 1.5 mA cm^(-2),with excellent cycling stability.Its capacity retention was 104%,even after 20,000 cycles.Bare BCMFs were also synthesized from the fungal biomass to fabricate a negative BCMFs/NF electrode.This,together with the positive NiMoO NPs@BCMFs/NF electrode,was used to construct a bio-friendly(hybrid-type)micro-supercapacitor(BMSC),which exhibited maximum energy and power density values of 56µWh cm^(-2)and 11,250µW cm^(-2),respectively.When tested for its ability to power biomedical electronics,the BMSC device successfully operated an electrical muscle stimulator,inducing potential signals into a volunteer in real-time application.展开更多
Substrates or encapsulants in soft and stretchable formats are key components for transient,bioresorbable electronic systems;however,elastomeric polymers with desired mechanical and biochemical properties are very lim...Substrates or encapsulants in soft and stretchable formats are key components for transient,bioresorbable electronic systems;however,elastomeric polymers with desired mechanical and biochemical properties are very limited compared to nontransient counterparts.Here,we introduce a bioresorbable elastomer,poly(glycolide-co-ε-caprolactone)(PGCL),that contains excellent material properties including high elongation-at-break(<1300%),resilience and toughness,and tunable dissolution behaviors.Exploitation of PGCLs as polymer matrices,in combination with conducing polymers,yields stretchable,conductive composites for degradable interconnects,sensors,and actuators,which can reliably function under external strains.Integration of device components with wireless modules demonstrates elastic,transient electronic suture system with on-demand drug delivery for rapid recovery of postsurgical wounds in soft,time-dynamic tissues.展开更多
Flexible electronics has emerged as a continuously growing field of study.Two-dimensional(2D)materials often act as conductors and electrodes in elec-tronic devices,holding significant promise in the design of high-pe...Flexible electronics has emerged as a continuously growing field of study.Two-dimensional(2D)materials often act as conductors and electrodes in elec-tronic devices,holding significant promise in the design of high-performance,flexible electronics.Numerous studies have focused on harnessing the potential of these materials for the development of such devices.However,to date,the incorporation of 2D materials in flexible electronics has rarely been summa-rized or reviewed.Consequently,there is an urgent need to develop compre-hensive reviews for rapid updates on this evolving landscape.This review covers progress in complex material architectures based on 2D materials,including interfaces,heterostructures,and 2D/polymer composites.Addition-ally,it explores flexible and wearable energy storage and conversion,display and touch technologies,and biomedical applications,together with integrated design solutions.Although the pursuit of high-performance and high-sensitivity instruments remains a primary objective,the integrated design of flexible electronics with 2D materials also warrants consideration.By combin-ing multiple functionalities into a singular device,augmented by machine learning and algorithms,we can potentially surpass the performance of existing wearable technologies.Finally,we briefly discuss the future trajectory of this burgeoning field.This review discusses the recent advancements in flex-ible sensors made from 2D materials and their applications in integrated archi-tecture and device design.展开更多
A system that allows computer interaction by disabled people with very low mobility and who cannot use the standard procedure based on keyboard and mouse is presented. The development device uses the patient’s volunt...A system that allows computer interaction by disabled people with very low mobility and who cannot use the standard procedure based on keyboard and mouse is presented. The development device uses the patient’s voluntary biomechanical signals, specifically, winks—which constitute an ability that generally remains in this kind of patients—, as interface to control the computer. A prototype based on robust and low-cost elements has been built and its performance has been validated through real trials by 16 users without previous training. The system can be optimized after a learning period in order to be adapted to every user. Also, good results were obtained in a subjective satisfaction survey that was completed by the users after carrying out the test trials.展开更多
基金the NSF CCSS-2152638 and the IEN Center Grant from the Institute for Electronics and Nanotechnology at Georgia Tech.
文摘This review summarizes recent progress in developing wireless,batteryless,fully implantable biomedical devices for real-time continuous physiological signal monitoring,focusing on advancing human health care.Design considerations,such as biological constraints,energy sourcing,and wireless communication,are discussed in achieving the desired performance of the devices and enhanced interface with human tissues.In addition,we review the recent achievements in materials used for developing implantable systems,emphasizing their importance in achieving multi-functionalities,biocompatibility,and hemocompatibility.The wireless,batteryless devices offer minimally invasive device insertion to the body,enabling portable health monitoring and advanced disease diagnosis.Lastly,we summarize the most recent practical applications of advanced implantable devices for human health care,highlighting their potential for immediate commercialization and clinical uses.
基金supported by the National Research Foundation of Korea(NRF)grant funded by the Korea government(MSIP)(No.2018R1A6A1A03025708).
文摘In various biomedical fields,noninvasive medical procedures are favored over invasive techniques,as the latter require major incisions or surgeries that cause bleeding,pain,and tissue scarring.The increased use of noninvasive biomedical equipment has created a demand for effective energy storage devices that are sufficiently compact to be used as a power source,easy to commercialize,and bio-friendly.Herein,we report the facile synthesis of nickel molybdenum oxide nanoparticle-infused biocarbon microfibers(NiMoO NPs@BCMFs)as a novel energy storage material.The microfibers were derived from the bracket fungus Laetiporus sulphureus.In a three-electrode system,the NiMoO NPs@BCMFs/nickel foam(NF)electrode delivered an areal capacity of 113µAh cm^(-2)at 1.5 mA cm^(-2),with excellent cycling stability.Its capacity retention was 104%,even after 20,000 cycles.Bare BCMFs were also synthesized from the fungal biomass to fabricate a negative BCMFs/NF electrode.This,together with the positive NiMoO NPs@BCMFs/NF electrode,was used to construct a bio-friendly(hybrid-type)micro-supercapacitor(BMSC),which exhibited maximum energy and power density values of 56µWh cm^(-2)and 11,250µW cm^(-2),respectively.When tested for its ability to power biomedical electronics,the BMSC device successfully operated an electrical muscle stimulator,inducing potential signals into a volunteer in real-time application.
基金supported by the KIST Institutional Program (Project No.2E32501-23-106)the KU-KIST Graduate School of Converging Science and Technology Program+3 种基金the National Research Foundation of Korea (NRF) grant funded by the Korean government (the Ministry of Science, ICT, MSIT) (RS-2022-00165524)the development of technologies for electroceuticals of the National Research Foundataion (NRF) funded by the Korean government (MSIT) (RS-2023-00220534)the Ministry of Science and ICT (MSIT), Korea, under the ICT Creative Consilience program (IITP-2023-2020-0-01819) supervised by the IITP (Institute for Information and Communications Technology Planning and Evaluation)Start up Pioneering in Research and Innovation(SPRINT) through the Commercialization Promotion Agency for R&D Outcomes(COMPA) grant funded by the Korea government(Ministry of Science and ICT) (1711198921)
文摘Substrates or encapsulants in soft and stretchable formats are key components for transient,bioresorbable electronic systems;however,elastomeric polymers with desired mechanical and biochemical properties are very limited compared to nontransient counterparts.Here,we introduce a bioresorbable elastomer,poly(glycolide-co-ε-caprolactone)(PGCL),that contains excellent material properties including high elongation-at-break(<1300%),resilience and toughness,and tunable dissolution behaviors.Exploitation of PGCLs as polymer matrices,in combination with conducing polymers,yields stretchable,conductive composites for degradable interconnects,sensors,and actuators,which can reliably function under external strains.Integration of device components with wireless modules demonstrates elastic,transient electronic suture system with on-demand drug delivery for rapid recovery of postsurgical wounds in soft,time-dynamic tissues.
基金supported by National Key Research and Development Program(No.2022YFE0124200)National Natural Science Foundation of China(No.U2241221)+9 种基金J.P.thanks the Natural Science Foundation of Shandong Province for Excellent Young Scholars(YQ2022041)the fund(No.SKT2203)from the State Key Laboratories of Transducer TechnologyShanghai Institute of Microsystem and Information Technology,Chinese Academy of Sciences for support.W.Z.thanks the Major Scientific and Technological Innovation Project of Shandong Province(2021CXGC010603)NSFC(No.52022037)Taishan Scholars Project Special Funds(TSQN201812083)The Project was supported by the Foundation(No.GZKF202107)of State Key Laboratory of Biobased Material and Green PapermakingQilu University of Technology,Shandong Academy of Sciences.M.H.R.thanks NSFC(No.52071225)the National Science Center and the Czech Republic under the European Regional Development Fund(ERDF)“Institute of Environmental Technology-Excellent Research”(No.CZ.02.1.01/0.0/0.0/16_019/0000853)the SinoGerman Center for Research Promotion(SGC)for support(No.GZ 1400).
文摘Flexible electronics has emerged as a continuously growing field of study.Two-dimensional(2D)materials often act as conductors and electrodes in elec-tronic devices,holding significant promise in the design of high-performance,flexible electronics.Numerous studies have focused on harnessing the potential of these materials for the development of such devices.However,to date,the incorporation of 2D materials in flexible electronics has rarely been summa-rized or reviewed.Consequently,there is an urgent need to develop compre-hensive reviews for rapid updates on this evolving landscape.This review covers progress in complex material architectures based on 2D materials,including interfaces,heterostructures,and 2D/polymer composites.Addition-ally,it explores flexible and wearable energy storage and conversion,display and touch technologies,and biomedical applications,together with integrated design solutions.Although the pursuit of high-performance and high-sensitivity instruments remains a primary objective,the integrated design of flexible electronics with 2D materials also warrants consideration.By combin-ing multiple functionalities into a singular device,augmented by machine learning and algorithms,we can potentially surpass the performance of existing wearable technologies.Finally,we briefly discuss the future trajectory of this burgeoning field.This review discusses the recent advancements in flex-ible sensors made from 2D materials and their applications in integrated archi-tecture and device design.
文摘A system that allows computer interaction by disabled people with very low mobility and who cannot use the standard procedure based on keyboard and mouse is presented. The development device uses the patient’s voluntary biomechanical signals, specifically, winks—which constitute an ability that generally remains in this kind of patients—, as interface to control the computer. A prototype based on robust and low-cost elements has been built and its performance has been validated through real trials by 16 users without previous training. The system can be optimized after a learning period in order to be adapted to every user. Also, good results were obtained in a subjective satisfaction survey that was completed by the users after carrying out the test trials.
