OBJECTIVE: To evaluate the efficacy of herb-partitioned moxibustion(HPM) at Qihai(CV6), Tianshu(ST25) and Shangjuxu(ST37) acupoints in relieving symptoms and the immune regulation of HPM on the toll-like receptors 4(T...OBJECTIVE: To evaluate the efficacy of herb-partitioned moxibustion(HPM) at Qihai(CV6), Tianshu(ST25) and Shangjuxu(ST37) acupoints in relieving symptoms and the immune regulation of HPM on the toll-like receptors 4(TLR4) signaling pathway in ulcerative colitis(UC) patients.METHODS: A randomized, single-blind study was conducted 63 patients to receive HPM or sham HPM treatment. The efficacy outcomes included scores of the Mayo, Baron, inflammatory bowel disease questionnaire(IBDQ), self-rating depression scale(SDS), self-rating anxiety scale(SAS). HE staining was used to observe the histopathological changes of the colon. The expression of inflammatory cytokines and TLR4 signaling pathway related molecules were determined by enzyme-linked immunosorbent assay and immunohistochemistry.RESULTS: Baron, SDS, SAS scores were significantly decreased in moxibustion group(P < 0.05), IBDQ score was significantly greater in the moxibustion group than in the sham moxibustion group(P < 0.05). Histopathology of mucosal biopsies showed that both two groups improved in mucosa after treatment. The expression levels of tumor necrosis factor-α, interleukin-2, interleukin-12, interferon-γ, and TLR4, lipopolysaccharide, myeloid differentiation factor 88, interleukin receptor associated kinase, tumor necrosis factor receptor associated factor 6 and nuclear factor kappa-B p65 were significantly lower in the moxibustion group than in the sham moxibustion group(P < 0.05).CONCLUSION: This study showed that HPM at Qihai(CV6), Tianshu(ST25) and Shangjuxu(ST37) acupoints is effective to relieve symptoms, anxiety, depression and improving life quality in UC patients,which may be related to the immune regulation of HPM on TLR4 signaling pathway.展开更多
This article reviews and applies the theories of two of the most prominent post-Napoleonic writers, the Baron de Jomini and Carl yon Clausewitz, to an obscure yet relevant battle in the American Civil War. Civil War c...This article reviews and applies the theories of two of the most prominent post-Napoleonic writers, the Baron de Jomini and Carl yon Clausewitz, to an obscure yet relevant battle in the American Civil War. Civil War commanders were trained in the Napoleonic art of war, and attempted on the battlefield to execute the basic principles of warfare as outlined by Jomini. Despite the best plans and executions of strategy and tactics, frictions in war, as discussed by von Clausewitz, tend to disrupt preparations and affect battle outcomes. The south Louisiana 1862 Battle of Labadieville serves as an ideal case study for fostering this thesis.展开更多
Objective To explore the clinical value of fecal calprotectin and myeloperoxidase in evaluation of ulcerative colitis(UC) activity.Methods Specimens of serum and feces over the same period were collected
触摸到一双精致的战靴,能够感受到主人气质,这是设计师的手笔,也是巴郎·戴维斯的风格展现。一双沉稳、灵活、内敛、实用的球鞋将伴随巴郎走过09—10赛季,这是他职业生涯的第一款签名鞋,也是李宁签名鞋史上的浓重一笔。十年,是磨砺...触摸到一双精致的战靴,能够感受到主人气质,这是设计师的手笔,也是巴郎·戴维斯的风格展现。一双沉稳、灵活、内敛、实用的球鞋将伴随巴郎走过09—10赛季,这是他职业生涯的第一款签名鞋,也是李宁签名鞋史上的浓重一笔。十年,是磨砺,是升华。十年的光阴,造就了今日的巴郎,一个老将在NBA摸爬滚打,有过晴空霹雳一样的战斧扣篮,也有过"黑八奇迹"的光辉岁月,从个人到团队,巴郎在用时间证明自己,而十年之后,一双早应属于他的战靴,铭记了岁月的痕迹。李宁BD1(Baron Davis 1),开启了后卫战靴的崭新篇章。展开更多
基金Supported by grants from the National Natural Science Foundation of China (No.81674074, 81774405, 81704161)three-year Action Plan Project of Shanghai Traditional Chinese Medicine Development [No.ZY(2018-2020)-CCCX-2004-01]+2 种基金project of Shanghai Municipal Health Commission (No.201840096)shanghai Municipal population and Family planning Commission "Excellent Youth Talent Training Program"(No.2018YQ11)Special Clinical Research Project in the Health Industry of Shanghai Municipal Health Commission (No.20204Y0245)。
文摘OBJECTIVE: To evaluate the efficacy of herb-partitioned moxibustion(HPM) at Qihai(CV6), Tianshu(ST25) and Shangjuxu(ST37) acupoints in relieving symptoms and the immune regulation of HPM on the toll-like receptors 4(TLR4) signaling pathway in ulcerative colitis(UC) patients.METHODS: A randomized, single-blind study was conducted 63 patients to receive HPM or sham HPM treatment. The efficacy outcomes included scores of the Mayo, Baron, inflammatory bowel disease questionnaire(IBDQ), self-rating depression scale(SDS), self-rating anxiety scale(SAS). HE staining was used to observe the histopathological changes of the colon. The expression of inflammatory cytokines and TLR4 signaling pathway related molecules were determined by enzyme-linked immunosorbent assay and immunohistochemistry.RESULTS: Baron, SDS, SAS scores were significantly decreased in moxibustion group(P < 0.05), IBDQ score was significantly greater in the moxibustion group than in the sham moxibustion group(P < 0.05). Histopathology of mucosal biopsies showed that both two groups improved in mucosa after treatment. The expression levels of tumor necrosis factor-α, interleukin-2, interleukin-12, interferon-γ, and TLR4, lipopolysaccharide, myeloid differentiation factor 88, interleukin receptor associated kinase, tumor necrosis factor receptor associated factor 6 and nuclear factor kappa-B p65 were significantly lower in the moxibustion group than in the sham moxibustion group(P < 0.05).CONCLUSION: This study showed that HPM at Qihai(CV6), Tianshu(ST25) and Shangjuxu(ST37) acupoints is effective to relieve symptoms, anxiety, depression and improving life quality in UC patients,which may be related to the immune regulation of HPM on TLR4 signaling pathway.
文摘This article reviews and applies the theories of two of the most prominent post-Napoleonic writers, the Baron de Jomini and Carl yon Clausewitz, to an obscure yet relevant battle in the American Civil War. Civil War commanders were trained in the Napoleonic art of war, and attempted on the battlefield to execute the basic principles of warfare as outlined by Jomini. Despite the best plans and executions of strategy and tactics, frictions in war, as discussed by von Clausewitz, tend to disrupt preparations and affect battle outcomes. The south Louisiana 1862 Battle of Labadieville serves as an ideal case study for fostering this thesis.
文摘Objective To explore the clinical value of fecal calprotectin and myeloperoxidase in evaluation of ulcerative colitis(UC) activity.Methods Specimens of serum and feces over the same period were collected
文摘触摸到一双精致的战靴,能够感受到主人气质,这是设计师的手笔,也是巴郎·戴维斯的风格展现。一双沉稳、灵活、内敛、实用的球鞋将伴随巴郎走过09—10赛季,这是他职业生涯的第一款签名鞋,也是李宁签名鞋史上的浓重一笔。十年,是磨砺,是升华。十年的光阴,造就了今日的巴郎,一个老将在NBA摸爬滚打,有过晴空霹雳一样的战斧扣篮,也有过"黑八奇迹"的光辉岁月,从个人到团队,巴郎在用时间证明自己,而十年之后,一双早应属于他的战靴,铭记了岁月的痕迹。李宁BD1(Baron Davis 1),开启了后卫战靴的崭新篇章。
