Background： Standard automated perimetry does not sufficiently detect early open-angle glaucoma （OAG） in the clinic. New visual function tests for early glaucoma damage are therefore needed. The present study evalu...Background： Standard automated perimetry does not sufficiently detect early open-angle glaucoma （OAG） in the clinic. New visual function tests for early glaucoma damage are therefore needed. The present study evaluated whether an isolated-check visual evoked potential （icVEP） could be used to detect visual function abnormalities in early-stage OAG and to explore potential related factors. Methods： This was a cross-sectional study. Thirty-seven OAG patients with early-stage visual field loss （mean deviation ≥ -6.00 dB） detected by the Humphrey Field Analyzer （30-2 SITA program） and 26 controls were included in this study. Optical coherence tomography （OCT） was used to detect retinal nerve fiber layer （RNFL） defects. The icVEP preferentially evaluates the magnocellular-ON pathway. VEPs were recorded and signal-to-noise ratios （SNRs） were derived based on multivariate analysis. Eyes that yielded an SNR ≤1 were considered abnormal. Receiver operating characteristic （ROC） curve analysis was used to estimate the accuracy of group classification. Correlations between SNRs and related factors were analyzed. Results： Based on an SNR criterion of 1, the icVEP had a sensitivity of 62.2% and a specificity of 92.3% for diagnosing early-stage OAG with 74.6% classification accuracy. The ROC curve analysis, however, suggested that an SNR criterion of 0.93 would produce the highest classification accuracy （77.3%）. Both RNFL thinning in the temporal superior quadrant on OCT and number of abnormal test points in the central 11° visual field （pattern deviation, P 〈 0.5%） significantly correlated with the SNR （P 〈 0.05）. Conclusions： The icVEP detected visual function abnormalities in approximately 3/5 of eyes with early-stage OAG with greater than 90% specificity. SNR correlated with both a decrease in RNFL thickness and severity of central visual field loss.展开更多
Objective To systemically explore the range of visual angles that affect visual acuity, and to establish the relationship between the P 1 component （peak latency -100 ms） of the pattern-reversal visual-evoked potent...Objective To systemically explore the range of visual angles that affect visual acuity, and to establish the relationship between the P 1 component （peak latency -100 ms） of the pattern-reversal visual-evoked potential （PRVEP） and the visual acuity at particular visual angles. Methods Two hundred and ten volunteers were divided into seven groups, according to visual acuity as assessed by the standard logarithmic visual acuity chart （SLD-II）. For each group, the PRVEP components were elicited in response to visual angle presentations at 8°, 4°, 2°, 1°/60＇, 30＇, 15＇, and 7.5＇, in the whiteblack chess-board reversal mode with a contrast level of 100% at a frequency of 2 Hz. Visual stimuli were presented monocularly, and 200 presentations were averaged for each block of trials. The early and stable component P1 was recorded at the mid-line of the occipital region （Oz） and analyzed with SPSS 13.00. Results （1） Oz had the maximum Pl amplitude; there was no significant difference between genders or for interocular comparison in normal controls and subjects with optic myopia. （2） The P1 latency decreased slowly below 30＇, then increased rapidly. The P1 amplitude initially increased with check size, and was maximal at -1° and -30＇. （3） The P1 latency in the group with visual acuity 〈0.2 was signifi- cantly different at 8°, 15＇ and 7.5＇, while the amplitude differed at all visual angles, compared with the group with normal vision. Differences in P1 for the groups with 0.5 and 0.6 acuity were only present at visual angles 〈1°. （4） Regression analysis showed that the P1 latency and amplitude were associated with visual acuity over the full range of visual angles. There was a moderate correlation at visual angles 〈30＇. Regression equations were calculated for the P1 components and visual acuity, based on visual angle. Conclusion （1） Visual angle should be taken into consideration when exploring the function of the visual pathway, especially visual acuity. A vi展开更多
In order to effectively solve the dead-zone and low-precision of T-shaped transmission line fault location,a new T-shaped transmission line fault location algorithm based on phase-angle jump checking is proposed in th...In order to effectively solve the dead-zone and low-precision of T-shaped transmission line fault location,a new T-shaped transmission line fault location algorithm based on phase-angle jump checking is proposed in this paper.Firstly,the 3-terminal synchronous fundamental positive sequence voltage and current phasors are extracted and substituted into the fault branch distance function to realize the selection of fault branch when the fault occurs;Secondly,use the condition of the fundamental positive sequence voltage phasor at the fault point is equal to calculate all roots(including real root and virtual roots);Finally,the phase-angle jump check function is used for checking calculation,and then the only real root can be determined as the actual fault distance,thereby achieving the purpose of high-precision fault location.MATLAB simulation results show that the proposed new algorithm is feasible and effective with high fault location accuracy and good versatility.展开更多
文摘Background： Standard automated perimetry does not sufficiently detect early open-angle glaucoma （OAG） in the clinic. New visual function tests for early glaucoma damage are therefore needed. The present study evaluated whether an isolated-check visual evoked potential （icVEP） could be used to detect visual function abnormalities in early-stage OAG and to explore potential related factors. Methods： This was a cross-sectional study. Thirty-seven OAG patients with early-stage visual field loss （mean deviation ≥ -6.00 dB） detected by the Humphrey Field Analyzer （30-2 SITA program） and 26 controls were included in this study. Optical coherence tomography （OCT） was used to detect retinal nerve fiber layer （RNFL） defects. The icVEP preferentially evaluates the magnocellular-ON pathway. VEPs were recorded and signal-to-noise ratios （SNRs） were derived based on multivariate analysis. Eyes that yielded an SNR ≤1 were considered abnormal. Receiver operating characteristic （ROC） curve analysis was used to estimate the accuracy of group classification. Correlations between SNRs and related factors were analyzed. Results： Based on an SNR criterion of 1, the icVEP had a sensitivity of 62.2% and a specificity of 92.3% for diagnosing early-stage OAG with 74.6% classification accuracy. The ROC curve analysis, however, suggested that an SNR criterion of 0.93 would produce the highest classification accuracy （77.3%）. Both RNFL thinning in the temporal superior quadrant on OCT and number of abnormal test points in the central 11° visual field （pattern deviation, P 〈 0.5%） significantly correlated with the SNR （P 〈 0.05）. Conclusions： The icVEP detected visual function abnormalities in approximately 3/5 of eyes with early-stage OAG with greater than 90% specificity. SNR correlated with both a decrease in RNFL thickness and severity of central visual field loss.
基金supported by grants from the National Nature Science Foundation of China(30872666,81172911 and 81271379)Shanghai Key Lab of Forensic Medicine(KF1005)
文摘Objective To systemically explore the range of visual angles that affect visual acuity, and to establish the relationship between the P 1 component （peak latency -100 ms） of the pattern-reversal visual-evoked potential （PRVEP） and the visual acuity at particular visual angles. Methods Two hundred and ten volunteers were divided into seven groups, according to visual acuity as assessed by the standard logarithmic visual acuity chart （SLD-II）. For each group, the PRVEP components were elicited in response to visual angle presentations at 8°, 4°, 2°, 1°/60＇, 30＇, 15＇, and 7.5＇, in the whiteblack chess-board reversal mode with a contrast level of 100% at a frequency of 2 Hz. Visual stimuli were presented monocularly, and 200 presentations were averaged for each block of trials. The early and stable component P1 was recorded at the mid-line of the occipital region （Oz） and analyzed with SPSS 13.00. Results （1） Oz had the maximum Pl amplitude; there was no significant difference between genders or for interocular comparison in normal controls and subjects with optic myopia. （2） The P1 latency decreased slowly below 30＇, then increased rapidly. The P1 amplitude initially increased with check size, and was maximal at -1° and -30＇. （3） The P1 latency in the group with visual acuity 〈0.2 was signifi- cantly different at 8°, 15＇ and 7.5＇, while the amplitude differed at all visual angles, compared with the group with normal vision. Differences in P1 for the groups with 0.5 and 0.6 acuity were only present at visual angles 〈1°. （4） Regression analysis showed that the P1 latency and amplitude were associated with visual acuity over the full range of visual angles. There was a moderate correlation at visual angles 〈30＇. Regression equations were calculated for the P1 components and visual acuity, based on visual angle. Conclusion （1） Visual angle should be taken into consideration when exploring the function of the visual pathway, especially visual acuity. A vi
基金supported by National Nature Science Foundation of China(51507031).
文摘In order to effectively solve the dead-zone and low-precision of T-shaped transmission line fault location,a new T-shaped transmission line fault location algorithm based on phase-angle jump checking is proposed in this paper.Firstly,the 3-terminal synchronous fundamental positive sequence voltage and current phasors are extracted and substituted into the fault branch distance function to realize the selection of fault branch when the fault occurs;Secondly,use the condition of the fundamental positive sequence voltage phasor at the fault point is equal to calculate all roots(including real root and virtual roots);Finally,the phase-angle jump check function is used for checking calculation,and then the only real root can be determined as the actual fault distance,thereby achieving the purpose of high-precision fault location.MATLAB simulation results show that the proposed new algorithm is feasible and effective with high fault location accuracy and good versatility.
