The prevalence of type 2 diabetes （T2DM）, which is characterized by insulin resistance, is increasingdramatically worldwide, and it has become a major public health issue. T2DM and cancer are common diseases that ar...The prevalence of type 2 diabetes （T2DM）, which is characterized by insulin resistance, is increasingdramatically worldwide, and it has become a major public health issue. T2DM and cancer are common diseases that are frequently diagnosed in the same individual and the relationship of them appears to be complex. Epidemiologic data have shown T2DM is significantly associated with cancer, but potential biologic links between the two diseases are not fully understood. MicroRNAs （miRNAs） are endogenously expressed RNAs consisting of 20-24 nucleotides that influence the expression of hundreds of genes that involved in numerous biological processes, including organ development, lipid metabolism, differentiation, apoptosis, and brain morphogenesis. MiRNAs are now shown to be stably expressed in serum,~ plasma,2 or blood.3＇4 Moreover, the unique expression patterns of these circulating miRNAs are correlated with specific human diseases,5 including various types of cancer and diabetes. Therefore, miRNAs in serum or plasma are emerging as novel blood-based fingerprints for the detection of human cancers with diabetes, especially at an early stage. Accumulating studies have association between T2DM demonstrated a significant and tumorigenesis. One of the mechanisms underlying is insulin resistance, which contributes to the development of T2DM and cancer. High expression of miRNAs 103 and 107 （miR-103/107） leads to insulin resistance by down regulating caveolin-1, which is the direct target gene of miR-103/1076 and also a critical regulator of insulin receptor. Downregulation of caveolin-1 is susceptible to be tumorigenesis.7 Emerging evidence suggests the important role of miR-103/107 in the development and progression of breast and colorectal cancer patients,8＇9 which of them are associated with diabetes, yet their roles in linking diabetes and cancer are only now beginning to be recognized. In this review, we discuss the current understanding of the molecular roles of miR-103/107 linking diabetes and cancer展开更多
BACKGROUND:With the objective of developing a locally- produced radioactive stent,the present study used in vivo animal experiments to explore apoptosis of proliferative smooth muscle cells resulting from facilitation...BACKGROUND:With the objective of developing a locally- produced radioactive stent,the present study used in vivo animal experiments to explore apoptosis of proliferative smooth muscle cells resulting from facilitation of the expression of genes caused byγ-radiation in order to prevent bile duct restenosis.We therefore explored the effects and significance ofγ-radiation on the activity of caspase-3,Fas and Bcl-2 genes in apoptosis of proliferative smooth muscle cells in the bile duct walls of dogs. METHODS:Twelve dogs were randomly divided into 2 groups(6 in each group).A postinjury bile duct stenosis model was established and radioactive 103 Pd( 103 palladium) or ordinary bile duct stents were implanted into the bile ducts.HE staining,RT-PCR and immunohistochemistry were used to detect the proliferation and apoptosis of bile duct smooth muscle cells in proliferative endomembrane and the expression of related caspase-3,Bcl-2 and Fas genes. RESULTS:The expression of caspase-3 and Fas genes in the bile duct tissues of dogs with radioactive stents was higher than that of dogs with ordinary stents.There was significant apoptosis of proliferative smooth muscle cells in the bile ducts.The expression of the Bcl-2 gene in the bile duct tissues of dogs with radioactive stents was lower than that in those with ordinary stents.There was significant apoptosis of proliferative smooth muscle cells in the dogs with low Bcl-2 gene expression. CONCLUSIONS:Radiation increases the activity of caspase-3 and Fas genes and is associated with apoptosis. The radioactive 103 Pd stent may facilitate apoptosis of proliferative smooth muscle cells in the bile ducts of dogs by activating these genes.The Bcl-2 gene expression level is correlated with the occurrence of apoptosis and the radiosusceptibility of cells.展开更多
介绍了西班牙国铁AVE S 103高速列车的主要技术参数,阐述了列车编组形式、受电弓、牵引变压器、主变流器、传动单元、辅助电路、制动系统、列车控制与诊断、列车安全系统、转向架、车辆人性化设计等方面的设计特点。指出该车在最高运行...介绍了西班牙国铁AVE S 103高速列车的主要技术参数,阐述了列车编组形式、受电弓、牵引变压器、主变流器、传动单元、辅助电路、制动系统、列车控制与诊断、列车安全系统、转向架、车辆人性化设计等方面的设计特点。指出该车在最高运行速度350km/h下具有高水平的舒适度,最佳的服务质量,较高的系统集成度,代表欧洲高速列车最先进水平。展开更多
Proteus species especially Proteus mirabilis and Proteus vulgaris are zoonotic pathogens which can cause public health disease.Owing to their antibiotic-resistance,developing vaccines against these pathogens is urgent...Proteus species especially Proteus mirabilis and Proteus vulgaris are zoonotic pathogens which can cause public health disease.Owing to their antibiotic-resistance,developing vaccines against these pathogens is urgently required.Herein,we describe the first synthesis of the common O-antigen of Proteus mirabilis OE and Proteus vulgaris TG 103.展开更多
The effective dose takes into consideration the amount of absorbed dose received by tissues, individual organs and also organ’s radiosensitivity. This study concentrates on the Commission’s regulations of 1991 and 2...The effective dose takes into consideration the amount of absorbed dose received by tissues, individual organs and also organ’s radiosensitivity. This study concentrates on the Commission’s regulations of 1991 and 2007 tagged ICRP 60 and ICRP 103 respectively, and seeks to suggest the better guideline for determination of detriment to patient especially from abdominopelvic computed tomography. With mean totals of 375.0 mSv for the ICRP 60 and 341.3 mSv for the ICRP 103 obtained from abdominopelvic computed tomography involving 20 different patients, a T-test calculated value of 6.716 was obtained and compared with the value in the T-table at 95% confidence limit and 18 degrees of freedom to confirm whether there is a significant difference in both ICRP 60 and 103 recommendations in the determination of the effective dose. Finally, it is concluded that there is a significant difference in the ICRP 60 and ICRP 103 as fewer effective doses are obtained from the ICRP 103 recommendations and this difference verifies that the ICRP 103 is more suitable for the determination of the effective dose.展开更多
Objective To study the clinicopathologic features of hepatic angiomyolipoma (AML) and to investigate the feasibility of a new antibody A103 as a diagnostic aid for AML Methods Ten cases of AML were retrieved from ...Objective To study the clinicopathologic features of hepatic angiomyolipoma (AML) and to investigate the feasibility of a new antibody A103 as a diagnostic aid for AML Methods Ten cases of AML were retrieved from hospital records and analyzed morphologically Immunohistochemistry was performed on paraffin embedded tissues with a panel of antibodies, including antibody A103 Results There were eight women and two men, with ages ranging from 38-58 years (median 45 7) Clinically, nine cases were asymptomatic and found by imaging techniques None of the patients had associated tuberous sclerosis All tumors were sharply demarcated from the surrounding liver parenchyma Histologically they were composed of a heterogeneous mixture of three components: thick walled blood vessels, spindle or epithelioid smooth muscle cells and adipose tissue All tumors showed a strong immunoreactivity to A103, HMB 45 and smooth muscle actins Follow up information on all 10 cases showed a benign course with no signs of recurrence Conclusions Hepatic AML is a rare mesenchymal tumor of the liver A103 is a promising marker for a pathologic diagnosis of hepatic AML展开更多
文摘The prevalence of type 2 diabetes （T2DM）, which is characterized by insulin resistance, is increasingdramatically worldwide, and it has become a major public health issue. T2DM and cancer are common diseases that are frequently diagnosed in the same individual and the relationship of them appears to be complex. Epidemiologic data have shown T2DM is significantly associated with cancer, but potential biologic links between the two diseases are not fully understood. MicroRNAs （miRNAs） are endogenously expressed RNAs consisting of 20-24 nucleotides that influence the expression of hundreds of genes that involved in numerous biological processes, including organ development, lipid metabolism, differentiation, apoptosis, and brain morphogenesis. MiRNAs are now shown to be stably expressed in serum,~ plasma,2 or blood.3＇4 Moreover, the unique expression patterns of these circulating miRNAs are correlated with specific human diseases,5 including various types of cancer and diabetes. Therefore, miRNAs in serum or plasma are emerging as novel blood-based fingerprints for the detection of human cancers with diabetes, especially at an early stage. Accumulating studies have association between T2DM demonstrated a significant and tumorigenesis. One of the mechanisms underlying is insulin resistance, which contributes to the development of T2DM and cancer. High expression of miRNAs 103 and 107 （miR-103/107） leads to insulin resistance by down regulating caveolin-1, which is the direct target gene of miR-103/1076 and also a critical regulator of insulin receptor. Downregulation of caveolin-1 is susceptible to be tumorigenesis.7 Emerging evidence suggests the important role of miR-103/107 in the development and progression of breast and colorectal cancer patients,8＇9 which of them are associated with diabetes, yet their roles in linking diabetes and cancer are only now beginning to be recognized. In this review, we discuss the current understanding of the molecular roles of miR-103/107 linking diabetes and cancer
文摘BACKGROUND:With the objective of developing a locally- produced radioactive stent,the present study used in vivo animal experiments to explore apoptosis of proliferative smooth muscle cells resulting from facilitation of the expression of genes caused byγ-radiation in order to prevent bile duct restenosis.We therefore explored the effects and significance ofγ-radiation on the activity of caspase-3,Fas and Bcl-2 genes in apoptosis of proliferative smooth muscle cells in the bile duct walls of dogs. METHODS:Twelve dogs were randomly divided into 2 groups(6 in each group).A postinjury bile duct stenosis model was established and radioactive 103 Pd( 103 palladium) or ordinary bile duct stents were implanted into the bile ducts.HE staining,RT-PCR and immunohistochemistry were used to detect the proliferation and apoptosis of bile duct smooth muscle cells in proliferative endomembrane and the expression of related caspase-3,Bcl-2 and Fas genes. RESULTS:The expression of caspase-3 and Fas genes in the bile duct tissues of dogs with radioactive stents was higher than that of dogs with ordinary stents.There was significant apoptosis of proliferative smooth muscle cells in the bile ducts.The expression of the Bcl-2 gene in the bile duct tissues of dogs with radioactive stents was lower than that in those with ordinary stents.There was significant apoptosis of proliferative smooth muscle cells in the dogs with low Bcl-2 gene expression. CONCLUSIONS:Radiation increases the activity of caspase-3 and Fas genes and is associated with apoptosis. The radioactive 103 Pd stent may facilitate apoptosis of proliferative smooth muscle cells in the bile ducts of dogs by activating these genes.The Bcl-2 gene expression level is correlated with the occurrence of apoptosis and the radiosusceptibility of cells.
文摘介绍了西班牙国铁AVE S 103高速列车的主要技术参数,阐述了列车编组形式、受电弓、牵引变压器、主变流器、传动单元、辅助电路、制动系统、列车控制与诊断、列车安全系统、转向架、车辆人性化设计等方面的设计特点。指出该车在最高运行速度350km/h下具有高水平的舒适度,最佳的服务质量,较高的系统集成度,代表欧洲高速列车最先进水平。
基金This work was financially supported by the National Natural Science Foundation of China(22167015,22077052,22177041,21977039)Science and Technology Department of Jiangxi Province(jxsq2020101084).
文摘Proteus species especially Proteus mirabilis and Proteus vulgaris are zoonotic pathogens which can cause public health disease.Owing to their antibiotic-resistance,developing vaccines against these pathogens is urgently required.Herein,we describe the first synthesis of the common O-antigen of Proteus mirabilis OE and Proteus vulgaris TG 103.
文摘The effective dose takes into consideration the amount of absorbed dose received by tissues, individual organs and also organ’s radiosensitivity. This study concentrates on the Commission’s regulations of 1991 and 2007 tagged ICRP 60 and ICRP 103 respectively, and seeks to suggest the better guideline for determination of detriment to patient especially from abdominopelvic computed tomography. With mean totals of 375.0 mSv for the ICRP 60 and 341.3 mSv for the ICRP 103 obtained from abdominopelvic computed tomography involving 20 different patients, a T-test calculated value of 6.716 was obtained and compared with the value in the T-table at 95% confidence limit and 18 degrees of freedom to confirm whether there is a significant difference in both ICRP 60 and 103 recommendations in the determination of the effective dose. Finally, it is concluded that there is a significant difference in the ICRP 60 and ICRP 103 as fewer effective doses are obtained from the ICRP 103 recommendations and this difference verifies that the ICRP 103 is more suitable for the determination of the effective dose.
基金ThestudywassponsoredbytheFoundationforLeadingMedicalSubjectofShanghaiHealthBureau (No 97BR0 2 9)
文摘Objective To study the clinicopathologic features of hepatic angiomyolipoma (AML) and to investigate the feasibility of a new antibody A103 as a diagnostic aid for AML Methods Ten cases of AML were retrieved from hospital records and analyzed morphologically Immunohistochemistry was performed on paraffin embedded tissues with a panel of antibodies, including antibody A103 Results There were eight women and two men, with ages ranging from 38-58 years (median 45 7) Clinically, nine cases were asymptomatic and found by imaging techniques None of the patients had associated tuberous sclerosis All tumors were sharply demarcated from the surrounding liver parenchyma Histologically they were composed of a heterogeneous mixture of three components: thick walled blood vessels, spindle or epithelioid smooth muscle cells and adipose tissue All tumors showed a strong immunoreactivity to A103, HMB 45 and smooth muscle actins Follow up information on all 10 cases showed a benign course with no signs of recurrence Conclusions Hepatic AML is a rare mesenchymal tumor of the liver A103 is a promising marker for a pathologic diagnosis of hepatic AML
