AIM To assess the possible roles of cytokines (TNF α, IFN γ, IL 6 and IL 8) in liver damage of hepatitis B. METHODS The serum TNF α, IFN γ, IL 6 and IL 8 were detected by ELISA in 66 patients with hepat...AIM To assess the possible roles of cytokines (TNF α, IFN γ, IL 6 and IL 8) in liver damage of hepatitis B. METHODS The serum TNF α, IFN γ, IL 6 and IL 8 were detected by ELISA in 66 patients with hepatitis B and 20 healthy blood donors. RESULTS TNF α and IL 6 in all types of clinical hepatitis B were significantly higher than those in healthy blood donors ( P <0 05); meanwhile the levels of TNF α, IFN γ, IL 6 and IL 8 in the patients with fulminant hepatitis B were much higher than those in the patients with acute hepatitis B ( P <0 05); the level of TNF α was positively correlated with the levels of IFN γ, Il 6 and IL 8 in all types of hepatitis B ( r IFN =0 24, r IL 6 =0 35, r IL 8 =0 44) and the TNF α, IFN γ, IL 6 and IL 8 were positively correlated with serum bilirubin ( P <0 05). Dynamic changes of these cytokines were observed in the course of acute and fulminant hepatitis. The level of IFN γ peaked in the initial period of acute hepatitis and early stage of hepatic coma in fulminant hepatitis; TNF α, IL 6 and IL 8 increased with exacerbation, and reached a peak when the liver damage was most serious, then decreased when patient conditions were improved. CONCLUSION The increased cytokines were related to the inflammation of liver cells and multiple factors may play certain roles in liver damage.展开更多
An earthquake of Ms 8 struck Wenchuan County, western Sichuan, China, on May 12^th, 2008 and resulted in long surface ruptures (〉300 km). The first-hand observations about the surface ruptures produced by the earth...An earthquake of Ms 8 struck Wenchuan County, western Sichuan, China, on May 12^th, 2008 and resulted in long surface ruptures (〉300 km). The first-hand observations about the surface ruptures produced by the earthquake in the worst-hit areas of Yingxiu, Beichuan and Qingchuan, ascertained that the causative structure of the earthquake was in the central fault zones of the Longmenshan tectonic belt. Average co-seismic vertical displacements along the individual fault of the Yingxiu-Beiehuan rupture zone reach 2.514 m and the cumulative vertical displacements across the central and frontal Longmenshan fault belt is about 5-6 m. The surface rupture strength was reduced from north of Beichuan to Qingchuan County and shows 2-3 m dextral strike-slip component. The Wenchuan thrust-faulting earthquake is a manifestation of eastward growth of the Tibetan Plateau under the action of continuous convergence of the Indian and Eurasian continents.展开更多
Two new isoflavones (8, 3'-dihydroxy-7,4'-dimethoxyisoflavone, odoratin-7-0-[3-D-glu-copyranoside) and four known isoflavones (formononetin, 7,3'-dihydroxy-8,4'-dimethoxyisoflavone, calycosin, calycosi...Two new isoflavones (8, 3'-dihydroxy-7,4'-dimethoxyisoflavone, odoratin-7-0-[3-D-glu-copyranoside) and four known isoflavones (formononetin, 7,3'-dihydroxy-8,4'-dimethoxyisoflavone, calycosin, calycosin-7-0-(3-D-glucopyranoside) were isolated from the roots of Astragalus mem-branaceus (Fisch.) Bunge. Their structures were established by spectral analysis.展开更多
文摘AIM To assess the possible roles of cytokines (TNF α, IFN γ, IL 6 and IL 8) in liver damage of hepatitis B. METHODS The serum TNF α, IFN γ, IL 6 and IL 8 were detected by ELISA in 66 patients with hepatitis B and 20 healthy blood donors. RESULTS TNF α and IL 6 in all types of clinical hepatitis B were significantly higher than those in healthy blood donors ( P <0 05); meanwhile the levels of TNF α, IFN γ, IL 6 and IL 8 in the patients with fulminant hepatitis B were much higher than those in the patients with acute hepatitis B ( P <0 05); the level of TNF α was positively correlated with the levels of IFN γ, Il 6 and IL 8 in all types of hepatitis B ( r IFN =0 24, r IL 6 =0 35, r IL 8 =0 44) and the TNF α, IFN γ, IL 6 and IL 8 were positively correlated with serum bilirubin ( P <0 05). Dynamic changes of these cytokines were observed in the course of acute and fulminant hepatitis. The level of IFN γ peaked in the initial period of acute hepatitis and early stage of hepatic coma in fulminant hepatitis; TNF α, IL 6 and IL 8 increased with exacerbation, and reached a peak when the liver damage was most serious, then decreased when patient conditions were improved. CONCLUSION The increased cytokines were related to the inflammation of liver cells and multiple factors may play certain roles in liver damage.
文摘An earthquake of Ms 8 struck Wenchuan County, western Sichuan, China, on May 12^th, 2008 and resulted in long surface ruptures (〉300 km). The first-hand observations about the surface ruptures produced by the earthquake in the worst-hit areas of Yingxiu, Beichuan and Qingchuan, ascertained that the causative structure of the earthquake was in the central fault zones of the Longmenshan tectonic belt. Average co-seismic vertical displacements along the individual fault of the Yingxiu-Beiehuan rupture zone reach 2.514 m and the cumulative vertical displacements across the central and frontal Longmenshan fault belt is about 5-6 m. The surface rupture strength was reduced from north of Beichuan to Qingchuan County and shows 2-3 m dextral strike-slip component. The Wenchuan thrust-faulting earthquake is a manifestation of eastward growth of the Tibetan Plateau under the action of continuous convergence of the Indian and Eurasian continents.
基金This project is supported by National Center of New Drug Research,Science and Technology Committee and Educational Committee of Shanghai.
文摘Two new isoflavones (8, 3'-dihydroxy-7,4'-dimethoxyisoflavone, odoratin-7-0-[3-D-glu-copyranoside) and four known isoflavones (formononetin, 7,3'-dihydroxy-8,4'-dimethoxyisoflavone, calycosin, calycosin-7-0-(3-D-glucopyranoside) were isolated from the roots of Astragalus mem-branaceus (Fisch.) Bunge. Their structures were established by spectral analysis.