AIM To synthesize a series of new fused heterocyclic compounds containing 1,2,4-triazole and 1,3,4-thiadiazole rings. METHODS and RESULTS Nine new fused heterocyclic compounds have been synthesized by the reaction of ...AIM To synthesize a series of new fused heterocyclic compounds containing 1,2,4-triazole and 1,3,4-thiadiazole rings. METHODS and RESULTS Nine new fused heterocyclic compounds have been synthesized by the reaction of 3-p-nitrophenoxymethyl-4-amino-5-mercapto-1,2,4-triazole with aromatic aldehydes in the presence of acid. The reaction conditions for the synthesis have been investigated. The structures of the synthesized compounds were confirmed by elemental analysis, IR, 1HNMR and MS. All of the compounds were screened for their biological activities. CONCLUSION The results show that some compounds (2c, 2d, 2e, 2f) showed strong antibacterial activities.展开更多
以3-芳基/烷基-4-氨基-5-巯基-1,2,4-三唑为原料,经过环化和糖化反应,设计合成了10个未见报道的化合物3-芳基/烷基-6-S-2',3',4',6'-四-O-乙酰基-β-D-吡喃葡萄糖基-1,2,4-三唑并[3,4-b]-1,3,4-噻二唑(3a^3j),其结构经...以3-芳基/烷基-4-氨基-5-巯基-1,2,4-三唑为原料,经过环化和糖化反应,设计合成了10个未见报道的化合物3-芳基/烷基-6-S-2',3',4',6'-四-O-乙酰基-β-D-吡喃葡萄糖基-1,2,4-三唑并[3,4-b]-1,3,4-噻二唑(3a^3j),其结构经核磁共振波谱、高分辨质谱和红外光谱确认.生物活性测试表明,所有化合物均对大肠杆菌、金黄色葡萄球菌、枯草芽孢杆菌和白色念株菌表现出一定的抗菌活性,其中化合物3c对4种测试菌株的最小抑菌浓度(MIC)最低,且接近于氟康唑的参照数据,具有较强的抗菌活性.利用Auto Dock 4.0程序研究了目标化合物3a^3j与大肠杆菌FabⅠ受体蛋白分子的相互作用和结合自由能变化规律.展开更多
文摘AIM To synthesize a series of new fused heterocyclic compounds containing 1,2,4-triazole and 1,3,4-thiadiazole rings. METHODS and RESULTS Nine new fused heterocyclic compounds have been synthesized by the reaction of 3-p-nitrophenoxymethyl-4-amino-5-mercapto-1,2,4-triazole with aromatic aldehydes in the presence of acid. The reaction conditions for the synthesis have been investigated. The structures of the synthesized compounds were confirmed by elemental analysis, IR, 1HNMR and MS. All of the compounds were screened for their biological activities. CONCLUSION The results show that some compounds (2c, 2d, 2e, 2f) showed strong antibacterial activities.
文摘以3-芳基/烷基-4-氨基-5-巯基-1,2,4-三唑为原料,经过环化和糖化反应,设计合成了10个未见报道的化合物3-芳基/烷基-6-S-2',3',4',6'-四-O-乙酰基-β-D-吡喃葡萄糖基-1,2,4-三唑并[3,4-b]-1,3,4-噻二唑(3a^3j),其结构经核磁共振波谱、高分辨质谱和红外光谱确认.生物活性测试表明,所有化合物均对大肠杆菌、金黄色葡萄球菌、枯草芽孢杆菌和白色念株菌表现出一定的抗菌活性,其中化合物3c对4种测试菌株的最小抑菌浓度(MIC)最低,且接近于氟康唑的参照数据,具有较强的抗菌活性.利用Auto Dock 4.0程序研究了目标化合物3a^3j与大肠杆菌FabⅠ受体蛋白分子的相互作用和结合自由能变化规律.
