Poly(aryl ether ether ketone ketone)(PEEKK) is a kind important high-performance polymers due to their excellent thermal stability a nd other outstanding properties similar to PEEK and PEKK.However,the PEEKK’s ins ol...Poly(aryl ether ether ketone ketone)(PEEKK) is a kind important high-performance polymers due to their excellent thermal stability a nd other outstanding properties similar to PEEK and PEKK.However,the PEEKK’s ins olubility in common solutions and high melt point restrict its processing and ap plications.In this paper,a series of random copolymers composed of poly(aryl eth er ether ketone ketone)(PEEKK)/poly(aryl ether ketone ether ketone ketone) cont a ining bis(o-metheyl) moiety(DM-PEKEKK) were prepared by low temperatur e so lution polycondensation of 4,4′-bis(2,6-dimethylphenoxy)diphenylketone (o -M 2DPOBP),1,4-dipheoxylbenzene(DPB) and terephthaloyl chlorde(TPC) in 1,2 -dichloroethane with the presence of AlCl 3 and DMF. The copolymers were chara cterized by FT-IR,DSC,WAXD,TGA,etc.The results show that glass transitio n te mperature increases greatly with the increasing of the ratio of o-M 2DPOBP /DPB,while melting temperature and crystallinity of copolymers decrease.The solu bility of the copolymers is improved greatly,while the copolymers still exhibit excellent thermostability.展开更多
Reaction of the oligo（phenylenevinylene） 4,4＇-bis（2,5-dimethylstyryl）biphenyl （bdb） with CF3CO2Ag in benzene gave a novel octanuclear sandwich cluster [Ags（bdb）2（C6H6）2（CF3CO2）8]·2C6H6 （1）. The clu...Reaction of the oligo（phenylenevinylene） 4,4＇-bis（2,5-dimethylstyryl）biphenyl （bdb） with CF3CO2Ag in benzene gave a novel octanuclear sandwich cluster [Ags（bdb）2（C6H6）2（CF3CO2）8]·2C6H6 （1）. The clusters are packed on each other through strong n-n interactions to form ^1D ＇brick＇ chains, between which the solvated benzene molecules are located. TG analysis showed that cluster 1 could completely liberate the guest benzene molecules at 105℃ and the coordinated benzene molecules at 180 ℃. In solid state, cluster 1 exhibits fluorescence, and the emission band is red-shifted compared with that of free ligand bdb.展开更多
AIM： To investigate the molecular mechanisms involved in coagulation factor expression and/or function during direct hyperplasia （DH）-mediated liver regeneration. METHODS： Direct hyperplasia-mediated liver regener...AIM： To investigate the molecular mechanisms involved in coagulation factor expression and/or function during direct hyperplasia （DH）-mediated liver regeneration. METHODS： Direct hyperplasia-mediated liver regeneration was induced in female C57BL/6 mice by administering 1,4-bisr2-（3,5-dichloropyridyloxy）] benzene （TCPOBOP）, a representative hepatomitogen. Mice were weighed and sacrificed at various time points [Day 0 （D0： prior to injection）, 3 h, D1, D2, D3, and D10] after TCPOBOP administration to obtain liver and blood samples. Using the RNA samples extracted from the liver, a comprehensive analysis was performed on the hepatic gene expression profiling of coagulation-related factors by real-time RT-PCR （fibrinogen, prothrombin, factors Ⅴ, Ⅶ, Ⅷ, Ⅸ, Ⅹ, Ⅺ, Ⅻ, ⅩⅢβ , plasminogen, antithrombin, protein C, protein S, ADAMTS13, and VWF）. The corresponding plasma levels of coagulation factors （fibrinogen, prothrombin, factors Ⅴ, Ⅶ, Ⅷ, Ⅸ, Ⅹ, Ⅺ, Ⅻ, ⅩⅢ, and VWF） were also analyzed and compared with their mRNA levels. RESULTS： Gavage administration of TCPOBOP （3 mg/kg body weight） resulted in a marked and gradual increase in the weight of the mouse livers relative to the total body weight to 220% by D10 relative to the DO （control） ratios. At the peak of liver regeneration （D1 and D2）, the gene expression levels for most of the coagulationrelated factors （fibrinogen, prothrombin, factors Ⅴ, Ⅶ, Ⅷ, Ⅸ,Ⅺ, Ⅻ, ⅩⅢβ, plasminogen, antithrombin, protein C, ADAMTS13, VWF） were found to be downregulated in a time-dependent manner, and gradually recovered by D10 to the basal levels. Only mRNA levels of factor X and protein S failed to show any decrease during the regenerative phase. As for the plasma levels, 5 clotting factors （prothrombin, factors Ⅷ, Ⅸ, Ⅺ, and Ⅻ） demonstrated a significant decrease （P 〈 0.05） during the regeneration phase compared with DO. Among these 5 factors, factor Ⅸ and factor Ⅺ showed the 展开更多
文摘Poly(aryl ether ether ketone ketone)(PEEKK) is a kind important high-performance polymers due to their excellent thermal stability a nd other outstanding properties similar to PEEK and PEKK.However,the PEEKK’s ins olubility in common solutions and high melt point restrict its processing and ap plications.In this paper,a series of random copolymers composed of poly(aryl eth er ether ketone ketone)(PEEKK)/poly(aryl ether ketone ether ketone ketone) cont a ining bis(o-metheyl) moiety(DM-PEKEKK) were prepared by low temperatur e so lution polycondensation of 4,4′-bis(2,6-dimethylphenoxy)diphenylketone (o -M 2DPOBP),1,4-dipheoxylbenzene(DPB) and terephthaloyl chlorde(TPC) in 1,2 -dichloroethane with the presence of AlCl 3 and DMF. The copolymers were chara cterized by FT-IR,DSC,WAXD,TGA,etc.The results show that glass transitio n te mperature increases greatly with the increasing of the ratio of o-M 2DPOBP /DPB,while melting temperature and crystallinity of copolymers decrease.The solu bility of the copolymers is improved greatly,while the copolymers still exhibit excellent thermostability.
文摘Reaction of the oligo（phenylenevinylene） 4,4＇-bis（2,5-dimethylstyryl）biphenyl （bdb） with CF3CO2Ag in benzene gave a novel octanuclear sandwich cluster [Ags（bdb）2（C6H6）2（CF3CO2）8]·2C6H6 （1）. The clusters are packed on each other through strong n-n interactions to form ^1D ＇brick＇ chains, between which the solvated benzene molecules are located. TG analysis showed that cluster 1 could completely liberate the guest benzene molecules at 105℃ and the coordinated benzene molecules at 180 ℃. In solid state, cluster 1 exhibits fluorescence, and the emission band is red-shifted compared with that of free ligand bdb.
基金Supported by Grants for AIDS Research from the Ministry of HealthLabor and Welfare of Japan (Shima M),Special Coordination Funds for Promoting Science and Technology (Ohashi K and Okano T)+1 种基金Grant-in-Aid (Ohashi K,No.21300180) from the Ministry of Education,Culture,Sports and Science and Technology (MEXT) of Japan (Ohashi K and Okano T)Novartis Foundation Japan (Ohashi K),and Bayer Hemophilia Award Program (Ohashi K)
文摘AIM： To investigate the molecular mechanisms involved in coagulation factor expression and/or function during direct hyperplasia （DH）-mediated liver regeneration. METHODS： Direct hyperplasia-mediated liver regeneration was induced in female C57BL/6 mice by administering 1,4-bisr2-（3,5-dichloropyridyloxy）] benzene （TCPOBOP）, a representative hepatomitogen. Mice were weighed and sacrificed at various time points [Day 0 （D0： prior to injection）, 3 h, D1, D2, D3, and D10] after TCPOBOP administration to obtain liver and blood samples. Using the RNA samples extracted from the liver, a comprehensive analysis was performed on the hepatic gene expression profiling of coagulation-related factors by real-time RT-PCR （fibrinogen, prothrombin, factors Ⅴ, Ⅶ, Ⅷ, Ⅸ, Ⅹ, Ⅺ, Ⅻ, ⅩⅢβ , plasminogen, antithrombin, protein C, protein S, ADAMTS13, and VWF）. The corresponding plasma levels of coagulation factors （fibrinogen, prothrombin, factors Ⅴ, Ⅶ, Ⅷ, Ⅸ, Ⅹ, Ⅺ, Ⅻ, ⅩⅢ, and VWF） were also analyzed and compared with their mRNA levels. RESULTS： Gavage administration of TCPOBOP （3 mg/kg body weight） resulted in a marked and gradual increase in the weight of the mouse livers relative to the total body weight to 220% by D10 relative to the DO （control） ratios. At the peak of liver regeneration （D1 and D2）, the gene expression levels for most of the coagulationrelated factors （fibrinogen, prothrombin, factors Ⅴ, Ⅶ, Ⅷ, Ⅸ,Ⅺ, Ⅻ, ⅩⅢβ, plasminogen, antithrombin, protein C, ADAMTS13, VWF） were found to be downregulated in a time-dependent manner, and gradually recovered by D10 to the basal levels. Only mRNA levels of factor X and protein S failed to show any decrease during the regenerative phase. As for the plasma levels, 5 clotting factors （prothrombin, factors Ⅷ, Ⅸ, Ⅺ, and Ⅻ） demonstrated a significant decrease （P 〈 0.05） during the regeneration phase compared with DO. Among these 5 factors, factor Ⅸ and factor Ⅺ showed the
