血管内皮生长因子VEGF及其受体VEGFR2对于肿瘤血管生成起至关重要的作用。本文旨在研究VEGFR2的咪唑并哒嗪类抑制剂的三维定量构效关系及新抑制剂分子与VEGFR2的作用机制。构建的Topomer Co MFA模型具有较强的预测能力和拟合能力(q^2=0....血管内皮生长因子VEGF及其受体VEGFR2对于肿瘤血管生成起至关重要的作用。本文旨在研究VEGFR2的咪唑并哒嗪类抑制剂的三维定量构效关系及新抑制剂分子与VEGFR2的作用机制。构建的Topomer Co MFA模型具有较强的预测能力和拟合能力(q^2=0.809,r^2=0.968)以及外部预测能力(r_(pred)~2=0.571)。应用Topomer Search技术在含1304868个分子的ZINC数据库中进行了虚拟筛选,采用基于片段的药物设计方法设计了68个高活性的新VEGFR2抑制剂。最后借助Surflex-dock技术研究了新分子与VEFGR2的作用机制,发现新抑制剂与残基Glu885、Cys919、Asn923、Asp1046等作用显著。本研究为VEGFR2抑制剂分子的结构修饰、设计与合成提供了重要的理论指导。展开更多
Grey system theory has been widely applied to many domains such as economy, agriculture, management, Social Sciences and so on. Based on the theory of grey system, this paper established GM（1,1） grey predict model f...Grey system theory has been widely applied to many domains such as economy, agriculture, management, Social Sciences and so on. Based on the theory of grey system, this paper established GM（1,1） grey predict model for the first time to forecast The number of Scitech novelty search item and The staff number of Sci-Tech Novelty Search. The predicting results are almost close to the actual values, which shows that the model is reliable so that the models could be used to forecast the two factors in the future years. The study will help the scientific management of Sci-Tech Novelty search work for Novelty search organizations.展开更多
After research on the motion estimation algorithm in video coding, a motion estimator algorithm with 1/4 pixel ac- curacy is implemented based on fie/d-programmable gate array （FPGA）. The motion estimation algorithm...After research on the motion estimation algorithm in video coding, a motion estimator algorithm with 1/4 pixel ac- curacy is implemented based on fie/d-programmable gate array （FPGA）. The motion estimation algorithm module is made up of the 1[4 pixel interpolation module with serial input and parallel output, the three step search module and the block match- ing module, which can use relatively less Wiener filters for interpolation operation. Experiment results show that the hard- ware design has less consumption of the logical resource, higher stability and lower power consumption.展开更多
文摘血管内皮生长因子VEGF及其受体VEGFR2对于肿瘤血管生成起至关重要的作用。本文旨在研究VEGFR2的咪唑并哒嗪类抑制剂的三维定量构效关系及新抑制剂分子与VEGFR2的作用机制。构建的Topomer Co MFA模型具有较强的预测能力和拟合能力(q^2=0.809,r^2=0.968)以及外部预测能力(r_(pred)~2=0.571)。应用Topomer Search技术在含1304868个分子的ZINC数据库中进行了虚拟筛选,采用基于片段的药物设计方法设计了68个高活性的新VEGFR2抑制剂。最后借助Surflex-dock技术研究了新分子与VEFGR2的作用机制,发现新抑制剂与残基Glu885、Cys919、Asn923、Asp1046等作用显著。本研究为VEGFR2抑制剂分子的结构修饰、设计与合成提供了重要的理论指导。
文摘Grey system theory has been widely applied to many domains such as economy, agriculture, management, Social Sciences and so on. Based on the theory of grey system, this paper established GM（1,1） grey predict model for the first time to forecast The number of Scitech novelty search item and The staff number of Sci-Tech Novelty Search. The predicting results are almost close to the actual values, which shows that the model is reliable so that the models could be used to forecast the two factors in the future years. The study will help the scientific management of Sci-Tech Novelty search work for Novelty search organizations.
基金The 8th Graduate Technology Fund of North University of China(No.201111)
文摘After research on the motion estimation algorithm in video coding, a motion estimator algorithm with 1/4 pixel ac- curacy is implemented based on fie/d-programmable gate array （FPGA）. The motion estimation algorithm module is made up of the 1[4 pixel interpolation module with serial input and parallel output, the three step search module and the block match- ing module, which can use relatively less Wiener filters for interpolation operation. Experiment results show that the hard- ware design has less consumption of the logical resource, higher stability and lower power consumption.
