摘要
阿尔采末病近年来发病率逐渐升高,对其发病机制的研究逐步深入。APP、PS1为已被明确的痴呆基因,γ-分泌酶是生成Aβ的限速酶,三者都是目前AD领域研究的热点,但是三者在AD间的具体相互作用机制及过程迄今还尚未明确,这些都可能是发现AD治疗新途径的潜在位点。
The incidence of Alzheimer＇s disease（AD） has grad- ually risen in recent years and the researches on mechanism of AD have gradually become deeper. APP and PS are the identi-fied genetic triggers that lead to AD, and gamma secretase is the key enzyme which produces Aβ. All three are the hotspots of re-search about AD. The three are obviously interrelated, but theinteractions among these three still remain unknown. Those are potential therapeutic sites to develop a new therapeutic approach of AD.
出处
《中国药理学通报》
CAS
CSCD
北大核心
2014年第2期167-169,共3页
Chinese Pharmacological Bulletin
基金
国家科技重大专项"重大新药创制"项目(No 2009ZX09103-391)
国家自然科学基金资助项目(No 81173383)
