BACKGROUND The incidence and mortality rate of colorectal cancer progressively increase with age and become particularly prominent after the age of 50 years.Therefore,the population that is≥50 years in age requires l...BACKGROUND The incidence and mortality rate of colorectal cancer progressively increase with age and become particularly prominent after the age of 50 years.Therefore,the population that is≥50 years in age requires long-term and regular colonoscopies.Uncomfortable bowel preparation is the main reason preventing patients from undergoing regular colonoscopies.The standard bowel preparation regimen of 4-L polyethylene glycol(PEG)is effective but poorly tolerated.AIM To investigate an effective and comfortable bowel preparation regimen for hospitalized patients≥50 years in age.METHODS Patients were randomly assigned to group 1(2-L PEG+30-mL lactulose+a lowresidue diet)or group 2(4-L PEG).Adequate bowel preparation was defined as a Boston bowel preparation scale(BBPS)score of≥6,with a score of≥2 for each segment.Non-inferiority was prespecified with a margin of 10%.Additionally,the degree of comfort was assessed based on the comfort questionnaire.RESULTS The proportion of patients with a BBPS score of≥6 in group 1 was not significantly different from that in group 2,as demonstrated by intention-to-treat(91.2%vs 91.0%,P=0.953)and per-protocol(91.8%vs 91.0%,P=0.802)analyses.Furthermore,in patients≥75 years in age,the proportion of BBPS scores of≥6 in group 1 was not significantly different from that in group 2(90.9%vs 97.0%,P=0.716).Group 1 had higher comfort scores(8.85±1.162 vs 7.59±1.735,P<0.001),longer sleep duration(6.86±1.204 h vs 5.80±1.730 h,P<0.001),and fewer awakenings(1.42±1.183 vs 2.04±1.835,P=0.026)than group 2.CONCLUSION For hospitalized patients≥50 years in age,the bowel preparation regimen comprising 2-L PEG+30-mL lactulose+a low-residue diet produced a cleanse that was as effective as the 4-L PEG regimen and even provided better comfort.展开更多
One of the first attempts to derive energy-to-peak performance criteria and state-feedback controller design problem for linear parameter-varying discrete time systems with time delay is provided. Firstly, we present ...One of the first attempts to derive energy-to-peak performance criteria and state-feedback controller design problem for linear parameter-varying discrete time systems with time delay is provided. Firstly, we present a parameter-dependent l 2-l ∞ performance criterion using a parameter-dependent Lyapunov function. Upon the conditions addressed, an improved parameter-dependent l 2-l ∞ performance criterion is established by the introduction of a slack variable, which exhibits a kind of decoupling between Lyapunov functions and system matrices. This kind of decoupling enables us to obtain more easily tractable conditions for analysis and synthesis problems. Then, the corresponding parameter-dependent state-feedback controller design is investigated upon these performance criteria, with sufficient conditions obtained for the existence of admissible controllers in terms of parameterized linear matrix inequalities. Finally, a numerical example is provided to illustrate the feasibility and advantage of the proposed controller design procedure.展开更多
Study of the SISO mixed H2/l1 problem for discrete time systems showed that there exists a unique optimal solution which can be approximated within any prescribed missing error bound in l2 norm with solvable suboptima...Study of the SISO mixed H2/l1 problem for discrete time systems showed that there exists a unique optimal solution which can be approximated within any prescribed missing error bound in l2 norm with solvable suboptimal solutions and solvable superoptimal solutions.展开更多
In this paper, taking the 2+1-dimensional sine-Gordon equation as an example, we present the concatenating method to construct the multisymplectic schemes. The method is to discretizee independently the PDEs in differ...In this paper, taking the 2+1-dimensional sine-Gordon equation as an example, we present the concatenating method to construct the multisymplectic schemes. The method is to discretizee independently the PDEs in different directions with symplectic schemes, so that the multisymplectic schemes can be constructed by concatenating those symplectic schemes. By this method, we can construct multisymplectic schemes, including some widely used schemes with an accuracy of any order. The numerical simulation on the collisions of solitons are also proposed to illustrate the efficiency of the multisymplectic schemes.展开更多
In this paper, by using a further extended tanh method- and symbolic computation system, some new soliton-like and period form solutions of the dispersive long-wave equation in (2+l )-dimensional spaces are obtained.
miR-142 and miR-223 have been identified as hematopoietic specific microRNAs, miR-223 has crucial functions in myeloid lineage development. However, the function of miR-142 remains unclear. In this study, we found tha...miR-142 and miR-223 have been identified as hematopoietic specific microRNAs, miR-223 has crucial functions in myeloid lineage development. However, the function of miR-142 remains unclear. In this study, we found that both miR-142 and miR-223 attenuated the proliferation of hematopoietic cells, and that miR-223 up-regulated miR-142 expression through the LMO2-L/-S isoforms and CEBP-p. miR-223 negatively regulated both LMO2-L/-S isoforms and CEBP-β post-transcriptionally, while CEBP-βpositively regulated the LMO2-L/-S isoforms and both of the LMO2-L/-S isoforms negatively regulated miR-142. These results reveal a novel miR-223--CEBP-β-LMO2-- miR-142 regulatory pathway, which has pivotal functions in hematopoiesis.展开更多
基金The study was approved by the Ethics Committee of Beijing Tongren Hospital Affiliated to Capital Medical University(Approval No.TRECKY2021-227).
文摘BACKGROUND The incidence and mortality rate of colorectal cancer progressively increase with age and become particularly prominent after the age of 50 years.Therefore,the population that is≥50 years in age requires long-term and regular colonoscopies.Uncomfortable bowel preparation is the main reason preventing patients from undergoing regular colonoscopies.The standard bowel preparation regimen of 4-L polyethylene glycol(PEG)is effective but poorly tolerated.AIM To investigate an effective and comfortable bowel preparation regimen for hospitalized patients≥50 years in age.METHODS Patients were randomly assigned to group 1(2-L PEG+30-mL lactulose+a lowresidue diet)or group 2(4-L PEG).Adequate bowel preparation was defined as a Boston bowel preparation scale(BBPS)score of≥6,with a score of≥2 for each segment.Non-inferiority was prespecified with a margin of 10%.Additionally,the degree of comfort was assessed based on the comfort questionnaire.RESULTS The proportion of patients with a BBPS score of≥6 in group 1 was not significantly different from that in group 2,as demonstrated by intention-to-treat(91.2%vs 91.0%,P=0.953)and per-protocol(91.8%vs 91.0%,P=0.802)analyses.Furthermore,in patients≥75 years in age,the proportion of BBPS scores of≥6 in group 1 was not significantly different from that in group 2(90.9%vs 97.0%,P=0.716).Group 1 had higher comfort scores(8.85±1.162 vs 7.59±1.735,P<0.001),longer sleep duration(6.86±1.204 h vs 5.80±1.730 h,P<0.001),and fewer awakenings(1.42±1.183 vs 2.04±1.835,P=0.026)than group 2.CONCLUSION For hospitalized patients≥50 years in age,the bowel preparation regimen comprising 2-L PEG+30-mL lactulose+a low-residue diet produced a cleanse that was as effective as the 4-L PEG regimen and even provided better comfort.
文摘One of the first attempts to derive energy-to-peak performance criteria and state-feedback controller design problem for linear parameter-varying discrete time systems with time delay is provided. Firstly, we present a parameter-dependent l 2-l ∞ performance criterion using a parameter-dependent Lyapunov function. Upon the conditions addressed, an improved parameter-dependent l 2-l ∞ performance criterion is established by the introduction of a slack variable, which exhibits a kind of decoupling between Lyapunov functions and system matrices. This kind of decoupling enables us to obtain more easily tractable conditions for analysis and synthesis problems. Then, the corresponding parameter-dependent state-feedback controller design is investigated upon these performance criteria, with sufficient conditions obtained for the existence of admissible controllers in terms of parameterized linear matrix inequalities. Finally, a numerical example is provided to illustrate the feasibility and advantage of the proposed controller design procedure.
文摘Study of the SISO mixed H2/l1 problem for discrete time systems showed that there exists a unique optimal solution which can be approximated within any prescribed missing error bound in l2 norm with solvable suboptimal solutions and solvable superoptimal solutions.
基金This work was supported by the National Natural Science Foundation of China Innovation Group(No.40221503)the CAS Hundred Talent Project,the National Key Development Planning Project for the Basic Research(No.1999032081)the National Natural Science Foundation of China(Grant No.10226012).
文摘In this paper, taking the 2+1-dimensional sine-Gordon equation as an example, we present the concatenating method to construct the multisymplectic schemes. The method is to discretizee independently the PDEs in different directions with symplectic schemes, so that the multisymplectic schemes can be constructed by concatenating those symplectic schemes. By this method, we can construct multisymplectic schemes, including some widely used schemes with an accuracy of any order. The numerical simulation on the collisions of solitons are also proposed to illustrate the efficiency of the multisymplectic schemes.
文摘In this paper, by using a further extended tanh method- and symbolic computation system, some new soliton-like and period form solutions of the dispersive long-wave equation in (2+l )-dimensional spaces are obtained.
基金This work was supported by the National Natural Science Foundation of China （Grant No. 30771054）.
文摘miR-142 and miR-223 have been identified as hematopoietic specific microRNAs, miR-223 has crucial functions in myeloid lineage development. However, the function of miR-142 remains unclear. In this study, we found that both miR-142 and miR-223 attenuated the proliferation of hematopoietic cells, and that miR-223 up-regulated miR-142 expression through the LMO2-L/-S isoforms and CEBP-p. miR-223 negatively regulated both LMO2-L/-S isoforms and CEBP-β post-transcriptionally, while CEBP-βpositively regulated the LMO2-L/-S isoforms and both of the LMO2-L/-S isoforms negatively regulated miR-142. These results reveal a novel miR-223--CEBP-β-LMO2-- miR-142 regulatory pathway, which has pivotal functions in hematopoiesis.
