目的观察止痛健骨方对原发性骨质疏松症(osteoprotegerin,OP)患者骨密度(bone mineral density,BMD)及骨保护蛋白(osteoprotegerin,OPG)、核因子-κβ受体活化因子配体(receptor activator of nuclear factor-κβligand,RANKL)的影响...目的观察止痛健骨方对原发性骨质疏松症(osteoprotegerin,OP)患者骨密度(bone mineral density,BMD)及骨保护蛋白(osteoprotegerin,OPG)、核因子-κβ受体活化因子配体(receptor activator of nuclear factor-κβligand,RANKL)的影响及疗效,探讨其治疗OP的作用机制。方法将原发性OP患者70例按入组顺序随机分为对照组和治疗组,各35例。两组均给予依降钙素、钙尔奇D等基础治疗,治疗组加服止痛健骨方煎剂,分别于治疗前、治疗8周后评价两组患者临床疗效,观察比较两组患者BMD、疼痛视觉模拟评分(visual analogue score,VAS)及血清OPG、RANKL的表达。结果治疗8周后,治疗组在改善症状方面明显优于对照组(P<0.05),BMD、血清OPG高于治疗前及对照组(P<0.05),VAS评分、血清RANKL低于治疗前及对照组(P<0.05)。结论止痛健骨方可有效提高OP患者OPG表达、降低RANKL表达,以达到增加患者BMD及改善症状的作用,这可能是其治疗原发性OP的作用机制之一。展开更多
Objective:To observe the clinical efficacy of heat-sensitive moxibustion plus medications on senile osteoporosis(SOP),and to explore the related mechanisms.Methods:A total of 70 elderly participants with osteoporosis ...Objective:To observe the clinical efficacy of heat-sensitive moxibustion plus medications on senile osteoporosis(SOP),and to explore the related mechanisms.Methods:A total of 70 elderly participants with osteoporosis were randomly divided into an observation group and control group,with 35 cases in each group.The control group was treated with conventional drugs,and the observation group was treated with heat-sensitive moxibustion on the basis of the conventional drugs.Both groups were treated for 3 months.Before and after treatment,assessed the visual analog scale(VAS)and Oswestry disability index(ODI)scores,determined the bone mineral density of the participants'lumbar spine(L2-L4)and left femoral neck,and detected the participants'serum bone morphogenetic protein-2(BMP-2)and osteoprotegerin(OPG)levels.Results:After treatment,the VAS scores of both groups were lower than before treatment(both P<0.05),and the VAS score of the observation group was significantly lower than that of the control group(P<0.05).After treatment,the bone mineral density values of the lumbar spine and left femoral neck in both groups were significantly higher than before treatment(both P<0.05),and the bone mineral density values of the observation group were higher than those of the control group(P<0.05).After treatment,the ODI scores of the two groups were lower than those before treatment(both P<0.05),and the ODI score of the observation group was lower than that of the control group(P<0.05).After treatment,the serum BMP-2 and OPG levels in the observation group were significantly higher than those in the control group(both P<0.05).Conclusion:Heat-sensitive moxibustion plus medications for SOP can significantly relieve patients'pain,improve dysfunction,and increase bone density,which may be related to the improvement of the serum BMP-2 and OPG levels.展开更多
文摘目的观察止痛健骨方对原发性骨质疏松症(osteoprotegerin,OP)患者骨密度(bone mineral density,BMD)及骨保护蛋白(osteoprotegerin,OPG)、核因子-κβ受体活化因子配体(receptor activator of nuclear factor-κβligand,RANKL)的影响及疗效,探讨其治疗OP的作用机制。方法将原发性OP患者70例按入组顺序随机分为对照组和治疗组,各35例。两组均给予依降钙素、钙尔奇D等基础治疗,治疗组加服止痛健骨方煎剂,分别于治疗前、治疗8周后评价两组患者临床疗效,观察比较两组患者BMD、疼痛视觉模拟评分(visual analogue score,VAS)及血清OPG、RANKL的表达。结果治疗8周后,治疗组在改善症状方面明显优于对照组(P<0.05),BMD、血清OPG高于治疗前及对照组(P<0.05),VAS评分、血清RANKL低于治疗前及对照组(P<0.05)。结论止痛健骨方可有效提高OP患者OPG表达、降低RANKL表达,以达到增加患者BMD及改善症状的作用,这可能是其治疗原发性OP的作用机制之一。
文摘Objective:To observe the clinical efficacy of heat-sensitive moxibustion plus medications on senile osteoporosis(SOP),and to explore the related mechanisms.Methods:A total of 70 elderly participants with osteoporosis were randomly divided into an observation group and control group,with 35 cases in each group.The control group was treated with conventional drugs,and the observation group was treated with heat-sensitive moxibustion on the basis of the conventional drugs.Both groups were treated for 3 months.Before and after treatment,assessed the visual analog scale(VAS)and Oswestry disability index(ODI)scores,determined the bone mineral density of the participants'lumbar spine(L2-L4)and left femoral neck,and detected the participants'serum bone morphogenetic protein-2(BMP-2)and osteoprotegerin(OPG)levels.Results:After treatment,the VAS scores of both groups were lower than before treatment(both P<0.05),and the VAS score of the observation group was significantly lower than that of the control group(P<0.05).After treatment,the bone mineral density values of the lumbar spine and left femoral neck in both groups were significantly higher than before treatment(both P<0.05),and the bone mineral density values of the observation group were higher than those of the control group(P<0.05).After treatment,the ODI scores of the two groups were lower than those before treatment(both P<0.05),and the ODI score of the observation group was lower than that of the control group(P<0.05).After treatment,the serum BMP-2 and OPG levels in the observation group were significantly higher than those in the control group(both P<0.05).Conclusion:Heat-sensitive moxibustion plus medications for SOP can significantly relieve patients'pain,improve dysfunction,and increase bone density,which may be related to the improvement of the serum BMP-2 and OPG levels.
