摘要
目的总结骨重建过程中降钙素基因相关肽(calcitonin gene-related peptide,CGRP)与核因子κB受体活化因子(receptor activator of nuclear factorκB,RANK)/核因子κB受体活化因子配体(receptor activator of nuclear factorκB ligand,RANKL)/骨保护蛋白(osteoprotegerin,OPG)信号系统作用机制的研究进展,为进一步研究骨相关疾病的预防及治疗提供理论依据。方法广泛查阅国内外近年来骨重建过程中CGRP与RANK/RANKL/OPG信号系统相关文献,并加以分析总结。结果骨重建过程中,CGRP与RANK/RANKL/OPG信号系统发挥着重要调控作用。结论目前对于骨重建过程中CGRP与RANK/RANKL/OPG信号系统的作用机制研究仍不够深入,需进一步研究二者在骨重建过程中的具体作用方式、相互联系,明确作用机制,为临床上骨相关疾病的治疗带来新思路、新方法。
Objective To summarize the research progress on the calcitonin gene-related peptide (CGRP) and receptor activator of nuclear factor κB (RANK)/receptor activator of nuclear factor κB ligand (RANKL)/osteoprotegerin (OPG) system during bone reconstruction to provide theoretical basis for further research on the prevention and treatment of bone-related diseases.Methods The relevant research results at home and abroad in recent years were analyzed and summarized.Results CGRP and RANK/RANKL/OPG system play important regulatory roles in the bone reconstruction.Conclusion At present,the research on the mechanism of CGRP and RANK/RANKL/OPG system in bone reconstruction is insufficient.Therefore,it is necessary to study further on the process and interrelation of CGRP and RANK/RANKL/OPG system in bone reconstruction to confirm their mechanism,which will bring new ideas and methods for the treatment of bone related diseases in clinic.
作者
王诗尧
许少策
师政伟
武建超
雷栓虎
汪玉良
WANG Shiyao;XU Shaoce;SHI Zhengwei;WU Jianchao;LEI Shuanhu;WANG Yuliang(Department of Orthopedics,Lanzhou University Second Hospital,Lanzhou Gansu,730000,P.R.China;Orthopedics Key Laboratory of Gansu Province,Lanzhou Gansu,730000,P.R.China)
出处
《中国修复重建外科杂志》
CAS
CSCD
北大核心
2019年第4期511-515,共5页
Chinese Journal of Reparative and Reconstructive Surgery
基金
甘肃省科技支撑计划项目(1304FKCA091)
