红斑狼疮（lupus erythematosus,LE）是一种多见于15-40岁女性、临床表现多样、可累及全身多器官系统的自身免疫性疾病。典型的LE诊断并不困难,但常有一些不典型的病例,以某一系统受累为主,如果不提高认识就会误诊,失去早期治疗的机会,...红斑狼疮（lupus erythematosus,LE）是一种多见于15-40岁女性、临床表现多样、可累及全身多器官系统的自身免疫性疾病。典型的LE诊断并不困难,但常有一些不典型的病例,以某一系统受累为主,如果不提高认识就会误诊,失去早期治疗的机会,而且这种不典型的LE也常是临床中难做出诊断的一组疾病。狼疮带试验（lupus band test,LBT）特异性高,有助于LE的诊断及鉴别,展开更多
A 32-year-old man presented with conspicuous acneiform pitting scars on the right nasolabial fold of 3 years’duration (Fig. 1). He stated that the scars were preceded by erythematous plaques. Physical examination als...A 32-year-old man presented with conspicuous acneiform pitting scars on the right nasolabial fold of 3 years’duration (Fig. 1). He stated that the scars were preceded by erythematous plaques. Physical examination also revealed perilesional erythematous infiltration and telangiectasia. Tracing back the history, there was no malar erythema, oral ulcer, or arthralgia. A skin biopsy showed irregular acanthosis, follicular plugging, vacuolar degeneration of the basal cell layer with marked melanin incontinence, and heavy periadnexal mononuclear cell infiltration (Fig. 2a,b). Direct immunofluorescence studies displayed continuous granular deposition of immunoglobulin G (IgG) and C3 along the dermo-epidermal junction. The hemogram, antinuclear antibody (ANA) test, complement, and urinalysis were within normal limits. Based on the histopathologic findings and a positive lupus band test, a diagnosis of discoid lupus erythematosus (DLE) was made.展开更多
文摘红斑狼疮（lupus erythematosus,LE）是一种多见于15-40岁女性、临床表现多样、可累及全身多器官系统的自身免疫性疾病。典型的LE诊断并不困难,但常有一些不典型的病例,以某一系统受累为主,如果不提高认识就会误诊,失去早期治疗的机会,而且这种不典型的LE也常是临床中难做出诊断的一组疾病。狼疮带试验（lupus band test,LBT）特异性高,有助于LE的诊断及鉴别,
文摘A 32-year-old man presented with conspicuous acneiform pitting scars on the right nasolabial fold of 3 years’duration (Fig. 1). He stated that the scars were preceded by erythematous plaques. Physical examination also revealed perilesional erythematous infiltration and telangiectasia. Tracing back the history, there was no malar erythema, oral ulcer, or arthralgia. A skin biopsy showed irregular acanthosis, follicular plugging, vacuolar degeneration of the basal cell layer with marked melanin incontinence, and heavy periadnexal mononuclear cell infiltration (Fig. 2a,b). Direct immunofluorescence studies displayed continuous granular deposition of immunoglobulin G (IgG) and C3 along the dermo-epidermal junction. The hemogram, antinuclear antibody (ANA) test, complement, and urinalysis were within normal limits. Based on the histopathologic findings and a positive lupus band test, a diagnosis of discoid lupus erythematosus (DLE) was made.
