Objective: To study whole-brain MR measures derived from diffusion tensor i maging and magnetization transfer imaging(MTI) for the in vivo assessment of cum ulative neuropathologic changes in HIV and to evaluate the q...Objective: To study whole-brain MR measures derived from diffusion tensor i maging and magnetization transfer imaging(MTI) for the in vivo assessment of cum ulative neuropathologic changes in HIV and to evaluate the quantitative imaging strategies with respect to cognitive status measures including the severity of d ementia and the degree of impairment in specific cognitive domains including att ention, memory, constructional abilities, and motor speed. Methods: Quantitative whole-brain measurements, including fractional anisotropy (FA), apparent diff usion coefficient (ADC), and magnetization transfer ratio (MTR), were derived fr om histograms and compared in HIV and control participants. Relationships betwee n the MR and cognitive status measures were examined. Results: Wholebrain FA and MTR were reduced in patients with HIV and correlated with dementia severity. Wh ole-brain MTR and ADC were correlated with psychomotor deficits. Evaluation of relationships between the studied MR measures indicated a correlation between A DC and MTR; FA was not correlated with either ADC or MTR. Conclusions: Findings from this investigation support the use of quantitative whole-brain MR measure s for evaluation of disease burden in HIV. Reductions in whole-brain fractiona l anisotropy and magnetization transfer ratio (MTR) distinguished HIV and contro l subjects, and these measures were associated with dementia severity. Relations hips were identified between whole-brain MTR and apparent diffusion coefficien t and psychomotor deficits. Combining these quantitative strategies in neuroimag ing examinations may provide more comprehensive information concerning ongoing c hanges in the brains of HIV patients.展开更多
文摘Objective: To study whole-brain MR measures derived from diffusion tensor i maging and magnetization transfer imaging(MTI) for the in vivo assessment of cum ulative neuropathologic changes in HIV and to evaluate the quantitative imaging strategies with respect to cognitive status measures including the severity of d ementia and the degree of impairment in specific cognitive domains including att ention, memory, constructional abilities, and motor speed. Methods: Quantitative whole-brain measurements, including fractional anisotropy (FA), apparent diff usion coefficient (ADC), and magnetization transfer ratio (MTR), were derived fr om histograms and compared in HIV and control participants. Relationships betwee n the MR and cognitive status measures were examined. Results: Wholebrain FA and MTR were reduced in patients with HIV and correlated with dementia severity. Wh ole-brain MTR and ADC were correlated with psychomotor deficits. Evaluation of relationships between the studied MR measures indicated a correlation between A DC and MTR; FA was not correlated with either ADC or MTR. Conclusions: Findings from this investigation support the use of quantitative whole-brain MR measure s for evaluation of disease burden in HIV. Reductions in whole-brain fractiona l anisotropy and magnetization transfer ratio (MTR) distinguished HIV and contro l subjects, and these measures were associated with dementia severity. Relations hips were identified between whole-brain MTR and apparent diffusion coefficien t and psychomotor deficits. Combining these quantitative strategies in neuroimag ing examinations may provide more comprehensive information concerning ongoing c hanges in the brains of HIV patients.
