Dieulafoy＇s lesion is an unusual cause of recurrent GI bleeding. This report describes a case of actively bleeding Dieulafoy＇s lesion of the small bowel in which the diagnosis was made by capsule endoscopy, followed...Dieulafoy＇s lesion is an unusual cause of recurrent GI bleeding. This report describes a case of actively bleeding Dieulafoy＇s lesion of the small bowel in which the diagnosis was made by capsule endoscopy, followed by treatment with the use of push enteroscopy. The case illustrates that capsule endoscopy and enteroscopy are highly complementary in patients with small bowel diseases.展开更多
本试验利用甲氨蝶呤(MTX)诱导模型鼠小肠炎症,观察酵母水解物及小麦水解蛋白对MTX所致小肠炎症的小鼠肠道的修复作用。将32只ICR雄性小鼠随机分为4组,每组8只,养殖试验期6 d。A组(正常对照组)每天蒸馏水灌胃(10 m L/kg体重),前2 d每天...本试验利用甲氨蝶呤(MTX)诱导模型鼠小肠炎症,观察酵母水解物及小麦水解蛋白对MTX所致小肠炎症的小鼠肠道的修复作用。将32只ICR雄性小鼠随机分为4组,每组8只,养殖试验期6 d。A组(正常对照组)每天蒸馏水灌胃(10 m L/kg体重),前2 d每天腹腔注射生理盐水0.2 m L;B组每天蒸馏水灌胃(10 m L/kg体重),前2d每天腹腔注射MTX溶液0.2 m L;C组每天以30%酵母水解物乳液灌胃(10 m L/kg体重),前2 d腹腔注射MTX溶液0.2 m L;D组每天以30%小麦水解蛋白乳液灌胃(10 m L/kg体重),前2 d每天腹腔注射MTX溶液0.2 m L。末次灌胃结束后,各组小鼠禁食12 h后处死,解剖取样,染色观察小肠的组织结构变化,并用荧光定量PCR测定小肠组织中细胞炎症因子TNF-α和IL-10的表达。结果表明,相对于A组,B组肠道结构受到明显损伤,TNF-α和IL-10表达明显增多,说明炎症严重;C组和D组相对B组而言,肠道结构部分修复,TNF-α和IL-10表达显著降低,其中C组变化更明显,表明炎症得到了不同程度缓解。结果表明,小麦水解蛋白及酵母水解物对小鼠小肠炎症均具有一定修复作用,试验条件下酵母水解物效果更佳。展开更多
AIM： To investigate the sonographic features at time of diagnosis and follow-up in patients with neutropenic enterocolitis. METHODS： The sonographic findings in 14 patients with neutropenic enterocolitis were descri...AIM： To investigate the sonographic features at time of diagnosis and follow-up in patients with neutropenic enterocolitis. METHODS： The sonographic findings in 14 patients with neutropenic enterocolitis were described and evaluated regarding symptoms and clinical outcome. RESULTS： In all patients with neutropenic enterocolitis, the ileocoecal region was involved with wall thickening 〉10 mm. A transmural inflammatory pattern, hypervascularity of the thickened bowel wall and free abdominal fluid were the common findings. The sonographically revealed thickness of the bowel wall was associated with lethal outcome （P〈0.03）. In the 11 surviving patients, the improvement of clinical symptoms was accompanied by progressive reduction of intestinal wall thickness. CONCLUSION： High-end sonography of the bowel is a helpful tool for diagnosis, assessment of prognosis and follow-up of patients with neutropenic enterocolitis. The ultrasonographically revealed bowel thickness reflects the severity and the course of the disease, and seems to be predictive for the clinical outcome.展开更多
文摘Dieulafoy＇s lesion is an unusual cause of recurrent GI bleeding. This report describes a case of actively bleeding Dieulafoy＇s lesion of the small bowel in which the diagnosis was made by capsule endoscopy, followed by treatment with the use of push enteroscopy. The case illustrates that capsule endoscopy and enteroscopy are highly complementary in patients with small bowel diseases.
文摘本试验利用甲氨蝶呤(MTX)诱导模型鼠小肠炎症,观察酵母水解物及小麦水解蛋白对MTX所致小肠炎症的小鼠肠道的修复作用。将32只ICR雄性小鼠随机分为4组,每组8只,养殖试验期6 d。A组(正常对照组)每天蒸馏水灌胃(10 m L/kg体重),前2 d每天腹腔注射生理盐水0.2 m L;B组每天蒸馏水灌胃(10 m L/kg体重),前2d每天腹腔注射MTX溶液0.2 m L;C组每天以30%酵母水解物乳液灌胃(10 m L/kg体重),前2 d腹腔注射MTX溶液0.2 m L;D组每天以30%小麦水解蛋白乳液灌胃(10 m L/kg体重),前2 d每天腹腔注射MTX溶液0.2 m L。末次灌胃结束后,各组小鼠禁食12 h后处死,解剖取样,染色观察小肠的组织结构变化,并用荧光定量PCR测定小肠组织中细胞炎症因子TNF-α和IL-10的表达。结果表明,相对于A组,B组肠道结构受到明显损伤,TNF-α和IL-10表达明显增多,说明炎症严重;C组和D组相对B组而言,肠道结构部分修复,TNF-α和IL-10表达显著降低,其中C组变化更明显,表明炎症得到了不同程度缓解。结果表明,小麦水解蛋白及酵母水解物对小鼠小肠炎症均具有一定修复作用,试验条件下酵母水解物效果更佳。
文摘AIM： To investigate the sonographic features at time of diagnosis and follow-up in patients with neutropenic enterocolitis. METHODS： The sonographic findings in 14 patients with neutropenic enterocolitis were described and evaluated regarding symptoms and clinical outcome. RESULTS： In all patients with neutropenic enterocolitis, the ileocoecal region was involved with wall thickening 〉10 mm. A transmural inflammatory pattern, hypervascularity of the thickened bowel wall and free abdominal fluid were the common findings. The sonographically revealed thickness of the bowel wall was associated with lethal outcome （P〈0.03）. In the 11 surviving patients, the improvement of clinical symptoms was accompanied by progressive reduction of intestinal wall thickness. CONCLUSION： High-end sonography of the bowel is a helpful tool for diagnosis, assessment of prognosis and follow-up of patients with neutropenic enterocolitis. The ultrasonographically revealed bowel thickness reflects the severity and the course of the disease, and seems to be predictive for the clinical outcome.
