The conformational change of biological macromolecule is investigated from the point of quantum transition.A quantum theory on protein folding is proposed.Compared with other dynamical variables such as mobile electro...The conformational change of biological macromolecule is investigated from the point of quantum transition.A quantum theory on protein folding is proposed.Compared with other dynamical variables such as mobile electrons,chemical bonds and stretching-bending vibrations the molecular torsion has the lowest energy and can be looked as the slow variable of the system.Simultaneously,from the multi-minima property of torsion potential the local conformational states are well defined.Following the idea that the slow variables slave the fast ones and using the nonadiabaticity operator method we deduce the Hamiltonian describing conformational change.It is shown that the influence of fast variables on the macromolecule can fully be taken into account through a phase transformation of slow variable wave function.Starting from the conformation-transition Hamiltonian the nonradiative matrix element was calculated and a general formulas for protein folding rate was deduced.The analytical form of the formula was utilized to study the temperature dependence of protein folding rate and the curious non-Arrhenius temperature relation was interpreted.By using temperature dependence data the multi-torsion correlation was studied.The decoherence time of quantum torsion state is estimated.The proposed folding rate formula gives a unifying approach for the study of a large class problems of biological conformational change.展开更多
This work attempts to extend the fundamental theory for classic gas dynamics to viscous compressible flow,of which aeroacoustics will naturally be a special branch.As a continuation of Part I.Unbounded fluid(Mao et al...This work attempts to extend the fundamental theory for classic gas dynamics to viscous compressible flow,of which aeroacoustics will naturally be a special branch.As a continuation of Part I.Unbounded fluid(Mao et al.,2022),this paper studies the source of longitudinal field at solid boundary,caused by the on-wall kinematic and viscous dynamic coupling of longitudinal and transverse processes.We find that at this situation the easiest choice for the two independent thermodynamic variables is the dimensionless pressure P and temperature T.The two-level structure of boundary dynamics of longitudinal field is obtained by applying the continuity equation and its normal derivative to the surface.We show that the boundary dilatation flux represents faithfully the boundary production of vortex sound and entropy sound,and the mutual generation mechanism of the longitudinal and transverse fields on the boundary does not occur symmetrically"at the samc level,but appears along a zigzag route.At the first level,it is the pressure gradient that generates vorticity unidirectionally;while at the second level,it is the vorticity that generates dilatation unidirectionally.展开更多
This paper presents a deep reflection on the advective wave equations for velocity vector and dilatation discovered in the past decade.We show that these equations can form the theoretical basis of modern gas dynamics...This paper presents a deep reflection on the advective wave equations for velocity vector and dilatation discovered in the past decade.We show that these equations can form the theoretical basis of modern gas dynamics,because they dominate not only various complex viscous and heat-conducting gas flows but also their associated longitudinal waves,including aero-generated sound.Current aeroacoustics theory has been developing in a manner quite independently of gas dynamics;it is based on the advective wave equations for thermodynamic variables,say the exact Phillips equation of relative disturbance pressure as a representative one.However,these equations do not cover the fluid flow that generates and propagates sound waves.In using them,one has to assume simplified base-flow models,which we argue is the main theoretical obstacle to identifying sound source and achieving effective noise control.Instead,we show that the Phillips equation and alike is nothing but the first integral of the dilatation equation that also governs the longitudinal part of the flow field.Therefore,we conclude that modern aeroacoustics should merge back into the general unsteady gas dynamics as a special branch of it,with dilatation of multiple sources being a new additional and sharper sound variable.展开更多
In the study and the research of the troposphere, the knowledge about its pressure variation on the height is necessary and important. Of course, exist the sounding to make this work, but not always it is possible to ...In the study and the research of the troposphere, the knowledge about its pressure variation on the height is necessary and important. Of course, exist the sounding to make this work, but not always it is possible to access to sounding data when is necessary, so then, it is important to has others alternatives methods in order to replace it. The troposphere is basically a fluid, susceptible to be studied under the fluid mechanics and thermodynamics of the ideals gases without loss generalities. So, it is possible to study of the atmospheric air like as a continuous perfect gas. These facts are important questions to study the troposphere under the laws and beginning Physics, using its respective equations, in order to get a theoretical model to simulate the behavior of its thermodynamics variables and parameters. Working on this line, it was developed a model in order to simulate the tropospheric pressure variation on the height from its measure on surface data.展开更多
文摘The conformational change of biological macromolecule is investigated from the point of quantum transition.A quantum theory on protein folding is proposed.Compared with other dynamical variables such as mobile electrons,chemical bonds and stretching-bending vibrations the molecular torsion has the lowest energy and can be looked as the slow variable of the system.Simultaneously,from the multi-minima property of torsion potential the local conformational states are well defined.Following the idea that the slow variables slave the fast ones and using the nonadiabaticity operator method we deduce the Hamiltonian describing conformational change.It is shown that the influence of fast variables on the macromolecule can fully be taken into account through a phase transformation of slow variable wave function.Starting from the conformation-transition Hamiltonian the nonradiative matrix element was calculated and a general formulas for protein folding rate was deduced.The analytical form of the formula was utilized to study the temperature dependence of protein folding rate and the curious non-Arrhenius temperature relation was interpreted.By using temperature dependence data the multi-torsion correlation was studied.The decoherence time of quantum torsion state is estimated.The proposed folding rate formula gives a unifying approach for the study of a large class problems of biological conformational change.
基金supported by the National Natural Science Foundation of China(Grant Nos.12102365,91752202,11472016,11621202,and 12272371).
文摘This work attempts to extend the fundamental theory for classic gas dynamics to viscous compressible flow,of which aeroacoustics will naturally be a special branch.As a continuation of Part I.Unbounded fluid(Mao et al.,2022),this paper studies the source of longitudinal field at solid boundary,caused by the on-wall kinematic and viscous dynamic coupling of longitudinal and transverse processes.We find that at this situation the easiest choice for the two independent thermodynamic variables is the dimensionless pressure P and temperature T.The two-level structure of boundary dynamics of longitudinal field is obtained by applying the continuity equation and its normal derivative to the surface.We show that the boundary dilatation flux represents faithfully the boundary production of vortex sound and entropy sound,and the mutual generation mechanism of the longitudinal and transverse fields on the boundary does not occur symmetrically"at the samc level,but appears along a zigzag route.At the first level,it is the pressure gradient that generates vorticity unidirectionally;while at the second level,it is the vorticity that generates dilatation unidirectionally.
基金supported by the National Natural Science Foundation of China(Grant Nos.12102365,91752202 and 11472016)Luoqin Liu was supported by the Hundred Talents Program of the Chinese Academy of Sciences(CAS).
文摘This paper presents a deep reflection on the advective wave equations for velocity vector and dilatation discovered in the past decade.We show that these equations can form the theoretical basis of modern gas dynamics,because they dominate not only various complex viscous and heat-conducting gas flows but also their associated longitudinal waves,including aero-generated sound.Current aeroacoustics theory has been developing in a manner quite independently of gas dynamics;it is based on the advective wave equations for thermodynamic variables,say the exact Phillips equation of relative disturbance pressure as a representative one.However,these equations do not cover the fluid flow that generates and propagates sound waves.In using them,one has to assume simplified base-flow models,which we argue is the main theoretical obstacle to identifying sound source and achieving effective noise control.Instead,we show that the Phillips equation and alike is nothing but the first integral of the dilatation equation that also governs the longitudinal part of the flow field.Therefore,we conclude that modern aeroacoustics should merge back into the general unsteady gas dynamics as a special branch of it,with dilatation of multiple sources being a new additional and sharper sound variable.
文摘In the study and the research of the troposphere, the knowledge about its pressure variation on the height is necessary and important. Of course, exist the sounding to make this work, but not always it is possible to access to sounding data when is necessary, so then, it is important to has others alternatives methods in order to replace it. The troposphere is basically a fluid, susceptible to be studied under the fluid mechanics and thermodynamics of the ideals gases without loss generalities. So, it is possible to study of the atmospheric air like as a continuous perfect gas. These facts are important questions to study the troposphere under the laws and beginning Physics, using its respective equations, in order to get a theoretical model to simulate the behavior of its thermodynamics variables and parameters. Working on this line, it was developed a model in order to simulate the tropospheric pressure variation on the height from its measure on surface data.
