AIM： To establish a rabbit rectal VX2 carcinoma model for the study of rectal carcinoma.METHODS： A suspension of VX2 cells was injected into the rectum wall under the guidance of X-ray fluoroscopy. Computed tomograp...AIM： To establish a rabbit rectal VX2 carcinoma model for the study of rectal carcinoma.METHODS： A suspension of VX2 cells was injected into the rectum wall under the guidance of X-ray fluoroscopy. Computed tomography （CT） and magnetic resonance imaging （MRI） were used to observe tumorgrowth and metastasis at different phases. Pathological changes and spontaneous survival time of the rabbits were recorded.RESULTS： Two weeks after VX2 cell implantation, the tumor diameter ranged 4.1-5.8 mm and the success implantation rate was 81.8%. CT scanning showed low-density loci of the tumor in the rectum wail, while enhanced CT scanning demonstrated a symmetrical intensification in tumor loci. MRI scanning showed alow signal of the tumor on T1-weighted imaging anda high signal of the tumor on T2-weighted imaging.Both types of signals were intensified with enhanced MRI. Metastases to the liver and lung could beobserved 6 wk after VX2 cell implantation, and a largearea of necrosis appeared in the primary tumor. The spontaneous survival time of rabbits with cachexia and multiple organ failure was about 7 wk after VX2 cell implantation.CONCLUSION： The rabbit rectal VX2 carcinoma model we established has a high stability, and can be used in the study of rectal carcinoma.展开更多
目的研究三维适形放射治疗(3D CRT)对兔VX2胆总管移植瘤所致胆道梗阻的疗效。方法通过VX2胆总管移植瘤建立胆道梗阻模型。实验兔被随机分为放疗组和对照组。放疗组接受放射治疗,对照组单纯饲养1周。比较放疗前后2组实验兔胆道扩张程度...目的研究三维适形放射治疗(3D CRT)对兔VX2胆总管移植瘤所致胆道梗阻的疗效。方法通过VX2胆总管移植瘤建立胆道梗阻模型。实验兔被随机分为放疗组和对照组。放疗组接受放射治疗,对照组单纯饲养1周。比较放疗前后2组实验兔胆道扩张程度、肿瘤大小及微血管密度(MVD)。结果放疗组和对照组各纳入19只实验兔,放疗1周后放疗组肿瘤直径、胆总管管径及肝内胆管起始部管径明显低于放疗前(P均<0.01),且低于对照组单纯饲养1周后(P均<0.01)。放疗组与对照组MVD计数的差异具有统计学意义(t=11.43,P<0.01)。结论 3D CRT能够减轻兔VX2胆总管移植瘤所致的胆道梗阻程度。展开更多
文摘AIM： To establish a rabbit rectal VX2 carcinoma model for the study of rectal carcinoma.METHODS： A suspension of VX2 cells was injected into the rectum wall under the guidance of X-ray fluoroscopy. Computed tomography （CT） and magnetic resonance imaging （MRI） were used to observe tumorgrowth and metastasis at different phases. Pathological changes and spontaneous survival time of the rabbits were recorded.RESULTS： Two weeks after VX2 cell implantation, the tumor diameter ranged 4.1-5.8 mm and the success implantation rate was 81.8%. CT scanning showed low-density loci of the tumor in the rectum wail, while enhanced CT scanning demonstrated a symmetrical intensification in tumor loci. MRI scanning showed alow signal of the tumor on T1-weighted imaging anda high signal of the tumor on T2-weighted imaging.Both types of signals were intensified with enhanced MRI. Metastases to the liver and lung could beobserved 6 wk after VX2 cell implantation, and a largearea of necrosis appeared in the primary tumor. The spontaneous survival time of rabbits with cachexia and multiple organ failure was about 7 wk after VX2 cell implantation.CONCLUSION： The rabbit rectal VX2 carcinoma model we established has a high stability, and can be used in the study of rectal carcinoma.
文摘目的研究三维适形放射治疗(3D CRT)对兔VX2胆总管移植瘤所致胆道梗阻的疗效。方法通过VX2胆总管移植瘤建立胆道梗阻模型。实验兔被随机分为放疗组和对照组。放疗组接受放射治疗,对照组单纯饲养1周。比较放疗前后2组实验兔胆道扩张程度、肿瘤大小及微血管密度(MVD)。结果放疗组和对照组各纳入19只实验兔,放疗1周后放疗组肿瘤直径、胆总管管径及肝内胆管起始部管径明显低于放疗前(P均<0.01),且低于对照组单纯饲养1周后(P均<0.01)。放疗组与对照组MVD计数的差异具有统计学意义(t=11.43,P<0.01)。结论 3D CRT能够减轻兔VX2胆总管移植瘤所致的胆道梗阻程度。
