Background: Zoonotic cutaneous leishmaniasis (ZCL) caused by Leishmania major is a growing public health problem and endemic in many parts of the Kingdom of S audi Arabia. The vector is Phlebotomus papatasi and the an...Background: Zoonotic cutaneous leishmaniasis (ZCL) caused by Leishmania major is a growing public health problem and endemic in many parts of the Kingdom of S audi Arabia. The vector is Phlebotomus papatasi and the animal reservoirs are ma inly desert rodents. Methods: In this prospective study, the clinical and histop athological features of ZCL in 120 patients are described and classified. The ma jority of these patients (n =84) were non-Saudi expatriate workers who suffered mostly from multiple and severely inflamed nodulo-ulcerative lesions on the ex posed parts of the body. Saudi patients were mainly children (n=21) with few1-3 lesions on their limbs or sometimes unique erysipeloid facial lesions. Results: Histopathological grouping of ZCL lesions showed four types of granulomatous re actions based on the predominant types of inflammatory cells, presence or absenc e of necrosis and ranking of parasitic index. Conclusion: A possible correlation between histopathologic evolution of ZCL lesions and the immune status of the h ost is discussed.展开更多
The prevalence of Crohn’ s disease depends on geographic location and racial background. Arg702Trp, Gly908Arg, and Leu1007fsinsC mutations in the NOD2/CARD15 gene are associated with Crohn’ s disease in Caucasians. ...The prevalence of Crohn’ s disease depends on geographic location and racial background. Arg702Trp, Gly908Arg, and Leu1007fsinsC mutations in the NOD2/CARD15 gene are associated with Crohn’ s disease in Caucasians. The mutation rate among Israeli Jewish patients is 27% - 41% . The prevalence of Crohn’ s disease is much lower in the Israeli Arab compared to the Israeli Jewish population. We studied the NOD2/CARD15 mutation rate and disease phenotype (according to the Vienna classification) among the Israeli Arabs and compared them with those in an Israeli Jewish cohort. We recruited 66 Israeli Arab patients and 122 ethnically matched controls. Five patients (8.2% ) and three controls (2.3% ) carried one NOD2/CARD15 mutation. The phenotypic characteristics of the Arab and Jewish patients were very similar. We conclude that NOD2/CARD15 mutations do not contribute to Crohn’ s susceptibility in the Israeli Arab population and suggest that NOD2/CARD15 mutations have an important effect on Crohn’ s prevalence within a specific population but not on the phenotype.展开更多
Vitamin Ddeficiency [serum 25- hydroxyvitamin D < 25 nmol/L(< 10 ng/mL)] was identified in 92% of rachitic Arab children and 97% of their mothers compared with 22% of nonrachitic children and 52% of their mother...Vitamin Ddeficiency [serum 25- hydroxyvitamin D < 25 nmol/L(< 10 ng/mL)] was identified in 92% of rachitic Arab children and 97% of their mothers compared with 22% of nonrachitic children and 52% of their mothers. There was a positive correlation between maternal and child vitamin D levels. We conclude that mothers of rachitic children should be investigated and treated for vitamin D deficiency.展开更多
文摘Background: Zoonotic cutaneous leishmaniasis (ZCL) caused by Leishmania major is a growing public health problem and endemic in many parts of the Kingdom of S audi Arabia. The vector is Phlebotomus papatasi and the animal reservoirs are ma inly desert rodents. Methods: In this prospective study, the clinical and histop athological features of ZCL in 120 patients are described and classified. The ma jority of these patients (n =84) were non-Saudi expatriate workers who suffered mostly from multiple and severely inflamed nodulo-ulcerative lesions on the ex posed parts of the body. Saudi patients were mainly children (n=21) with few1-3 lesions on their limbs or sometimes unique erysipeloid facial lesions. Results: Histopathological grouping of ZCL lesions showed four types of granulomatous re actions based on the predominant types of inflammatory cells, presence or absenc e of necrosis and ranking of parasitic index. Conclusion: A possible correlation between histopathologic evolution of ZCL lesions and the immune status of the h ost is discussed.
文摘The prevalence of Crohn’ s disease depends on geographic location and racial background. Arg702Trp, Gly908Arg, and Leu1007fsinsC mutations in the NOD2/CARD15 gene are associated with Crohn’ s disease in Caucasians. The mutation rate among Israeli Jewish patients is 27% - 41% . The prevalence of Crohn’ s disease is much lower in the Israeli Arab compared to the Israeli Jewish population. We studied the NOD2/CARD15 mutation rate and disease phenotype (according to the Vienna classification) among the Israeli Arabs and compared them with those in an Israeli Jewish cohort. We recruited 66 Israeli Arab patients and 122 ethnically matched controls. Five patients (8.2% ) and three controls (2.3% ) carried one NOD2/CARD15 mutation. The phenotypic characteristics of the Arab and Jewish patients were very similar. We conclude that NOD2/CARD15 mutations do not contribute to Crohn’ s susceptibility in the Israeli Arab population and suggest that NOD2/CARD15 mutations have an important effect on Crohn’ s prevalence within a specific population but not on the phenotype.
文摘Vitamin Ddeficiency [serum 25- hydroxyvitamin D < 25 nmol/L(< 10 ng/mL)] was identified in 92% of rachitic Arab children and 97% of their mothers compared with 22% of nonrachitic children and 52% of their mothers. There was a positive correlation between maternal and child vitamin D levels. We conclude that mothers of rachitic children should be investigated and treated for vitamin D deficiency.
