乳腺导管内原位癌(ductal carcinoma in situ,DCIS)常表现为上皮层内癌细胞明显增生,未侵袭基底层[1]。但相比于小叶原位癌,其发展为浸润性癌的可能性更大[2],是一种更容易发展成浸润癌的原位癌。因此,DCIS已被列入癌前病变的范畴[3]。...乳腺导管内原位癌(ductal carcinoma in situ,DCIS)常表现为上皮层内癌细胞明显增生,未侵袭基底层[1]。但相比于小叶原位癌,其发展为浸润性癌的可能性更大[2],是一种更容易发展成浸润癌的原位癌。因此,DCIS已被列入癌前病变的范畴[3]。嗜酸细胞肿瘤(oncocytic carcinoma,OC)多发生在人体不同部位如腮腺、肾脏或甲状腺等器官[4~7],发生于乳腺较罕见。截至目前,关于乳腺嗜酸细胞癌的案例报道较少[8~11]。且既往案例报道的患者年龄大,同时病理类型均为单一的嗜酸细胞癌。本研究将对我院甲乳疝外科收治的1例嗜酸细胞癌和导管内原位癌并存的年轻乳腺癌患者进行临床及病理分析。同时通过总结归纳既往的文献,探讨其临床表现、诊断、鉴别诊断、治疗和生物学特性。展开更多
Background: The etiology of lymphocytic colitis, a microscopic colitis syndrome, has remained elusive. Because 1) many infectious enteritides exhibit seasonal variability in incidence and 2) a few investigators have p...Background: The etiology of lymphocytic colitis, a microscopic colitis syndrome, has remained elusive. Because 1) many infectious enteritides exhibit seasonal variability in incidence and 2) a few investigators have proposed some infectious mechanism in lymphocytic colitis, our aim was to determine if any variability in symptom onset existed among lymphocytic colitis patients diagnosed at our in stitution. Study: We identified 71 nonduplicated, consecutive patients with lymp hocytic colitis over a 4-year period using rigorous clinicopathologic inclusion criteria: 1) chronic watery diarrhea, 2) endoscopically normal colon, 3) no evi dence for celiac sprue or drug-induced colitis, 4) diffuse colitis with increas ed intraepithelial lymphocytes of at least 10 lymphocytes per 100 epithelial cel ls, 5) evidence of surface epithelial damage, and 6) no significant neutrophilic infiltrates, architectural distortion of the mucosa, or subepithelial collagen deposits. The date of diagnosis was corrected for month of onset of symptoms. Re sults: The distribution of month of onset of symptoms showed a statistically sig nificant (χ2 test of homogeneity, P = 0.0008) temporal variability and seasonal incidence pattern with excess cases during summer and fall and a paucity of cases during colder months. Conclusions: To our knowledge, this is the first study to examine systematically and report a significant seasonal inci dence pattern of lymphocytic colitis. Our observations may support a potential l ink to an infectious source in lymphocytic colitis.展开更多
文摘乳腺导管内原位癌(ductal carcinoma in situ,DCIS)常表现为上皮层内癌细胞明显增生,未侵袭基底层[1]。但相比于小叶原位癌,其发展为浸润性癌的可能性更大[2],是一种更容易发展成浸润癌的原位癌。因此,DCIS已被列入癌前病变的范畴[3]。嗜酸细胞肿瘤(oncocytic carcinoma,OC)多发生在人体不同部位如腮腺、肾脏或甲状腺等器官[4~7],发生于乳腺较罕见。截至目前,关于乳腺嗜酸细胞癌的案例报道较少[8~11]。且既往案例报道的患者年龄大,同时病理类型均为单一的嗜酸细胞癌。本研究将对我院甲乳疝外科收治的1例嗜酸细胞癌和导管内原位癌并存的年轻乳腺癌患者进行临床及病理分析。同时通过总结归纳既往的文献,探讨其临床表现、诊断、鉴别诊断、治疗和生物学特性。
文摘Background: The etiology of lymphocytic colitis, a microscopic colitis syndrome, has remained elusive. Because 1) many infectious enteritides exhibit seasonal variability in incidence and 2) a few investigators have proposed some infectious mechanism in lymphocytic colitis, our aim was to determine if any variability in symptom onset existed among lymphocytic colitis patients diagnosed at our in stitution. Study: We identified 71 nonduplicated, consecutive patients with lymp hocytic colitis over a 4-year period using rigorous clinicopathologic inclusion criteria: 1) chronic watery diarrhea, 2) endoscopically normal colon, 3) no evi dence for celiac sprue or drug-induced colitis, 4) diffuse colitis with increas ed intraepithelial lymphocytes of at least 10 lymphocytes per 100 epithelial cel ls, 5) evidence of surface epithelial damage, and 6) no significant neutrophilic infiltrates, architectural distortion of the mucosa, or subepithelial collagen deposits. The date of diagnosis was corrected for month of onset of symptoms. Re sults: The distribution of month of onset of symptoms showed a statistically sig nificant (χ2 test of homogeneity, P = 0.0008) temporal variability and seasonal incidence pattern with excess cases during summer and fall and a paucity of cases during colder months. Conclusions: To our knowledge, this is the first study to examine systematically and report a significant seasonal inci dence pattern of lymphocytic colitis. Our observations may support a potential l ink to an infectious source in lymphocytic colitis.
