The development of highly facile synthetic procedures for the expedient synthesis of complex natural molecules is always in demand.As this aspect,the Diels-Alder reaction(DAR)has a versatile approach to the synthesis ...The development of highly facile synthetic procedures for the expedient synthesis of complex natural molecules is always in demand.As this aspect,the Diels-Alder reaction(DAR)has a versatile approach to the synthesis of complex natural compounds and highly regio-/stereoselcetive heterocyclic scaffolds.Additionally,α-pyrone and terpeno-quinone are two versatile key intermediates that are prevalent in various bioactive natural compounds for instance,(±)-crinine,(±)-joubertinamine,(±)-pancratistatin,(−)-cyclozonarone,and 8-ephipuupehedione,etc.Hence,the current review summarizes the Diels-Alder reaction application ofα-pyrone and terpenoquinone to the construc-tive synthesis of various natural products over the past two decades(2001-2021).Equally,it serves as a stencil for the invention and development of new synthetic strategies for high-complex molecular structured natural and heterocy-clic molecules.展开更多
Aim To study the chemical composition of Opuntia dillenii Haw. Methods Manykinds of chromatogra-phy methods were used in the isolation procedure, while the structures ofisolated compounds were determined on the aids o...Aim To study the chemical composition of Opuntia dillenii Haw. Methods Manykinds of chromatogra-phy methods were used in the isolation procedure, while the structures ofisolated compounds were determined on the aids of NMR and MS spectral analysis. Result Three newcompounds, together with 14 known compounds, were isolated form the 80% ethanolic extract of itsstems. Conclusion The three new compounds, opuntioside Ⅰ (2), 4-ethoxyl-6-hydroxymethyl-α-pyrone(3) and kaempferol 7-O-β-D-glucopyranosyl (1→4)-β-D-glucopyranoside (4), were characterized.展开更多
6-Pentyl-α-pyrone (6PP), a natural product with a number of bioactivies, has been synthesized from furfural in a five steps route. The key step is the epoxidation of 2-furyl-pentylcarbinol (3) with NBS in a mixed sol...6-Pentyl-α-pyrone (6PP), a natural product with a number of bioactivies, has been synthesized from furfural in a five steps route. The key step is the epoxidation of 2-furyl-pentylcarbinol (3) with NBS in a mixed solvent system THF and H2O(4: 1). The overall yield is 34%.展开更多
基金Council on grants of the President of the Russian Federation, HШ-2700.2020.3, Zyryanov Grigory V., Российский Фонд Фундаментальных Исследований (РФФИ), Grant # 21-13-00304, Zyryanov Grigory V.
文摘The development of highly facile synthetic procedures for the expedient synthesis of complex natural molecules is always in demand.As this aspect,the Diels-Alder reaction(DAR)has a versatile approach to the synthesis of complex natural compounds and highly regio-/stereoselcetive heterocyclic scaffolds.Additionally,α-pyrone and terpeno-quinone are two versatile key intermediates that are prevalent in various bioactive natural compounds for instance,(±)-crinine,(±)-joubertinamine,(±)-pancratistatin,(−)-cyclozonarone,and 8-ephipuupehedione,etc.Hence,the current review summarizes the Diels-Alder reaction application ofα-pyrone and terpenoquinone to the construc-tive synthesis of various natural products over the past two decades(2001-2021).Equally,it serves as a stencil for the invention and development of new synthetic strategies for high-complex molecular structured natural and heterocy-clic molecules.
文摘Aim To study the chemical composition of Opuntia dillenii Haw. Methods Manykinds of chromatogra-phy methods were used in the isolation procedure, while the structures ofisolated compounds were determined on the aids of NMR and MS spectral analysis. Result Three newcompounds, together with 14 known compounds, were isolated form the 80% ethanolic extract of itsstems. Conclusion The three new compounds, opuntioside Ⅰ (2), 4-ethoxyl-6-hydroxymethyl-α-pyrone(3) and kaempferol 7-O-β-D-glucopyranosyl (1→4)-β-D-glucopyranoside (4), were characterized.
文摘6-Pentyl-α-pyrone (6PP), a natural product with a number of bioactivies, has been synthesized from furfural in a five steps route. The key step is the epoxidation of 2-furyl-pentylcarbinol (3) with NBS in a mixed solvent system THF and H2O(4: 1). The overall yield is 34%.
