以天然产物白杨素为原料,与多种α-溴代苯乙酮反应制得6种7-(2-羰基-2-苯基)乙氧基白杨素衍生物(2a^2f);2a^2f与盐酸羟胺进行肟化反应,合成了6种新型的Z-构型7-(2-羟亚胺-2-苯基)乙氧基白杨素衍生物(3a^3f),其结构经1 H NMR,13 C NMR,IR...以天然产物白杨素为原料,与多种α-溴代苯乙酮反应制得6种7-(2-羰基-2-苯基)乙氧基白杨素衍生物(2a^2f);2a^2f与盐酸羟胺进行肟化反应,合成了6种新型的Z-构型7-(2-羟亚胺-2-苯基)乙氧基白杨素衍生物(3a^3f),其结构经1 H NMR,13 C NMR,IR和HR-MS(ESI)表征。采用MTT法测试了3a^3f对人宫颈癌细胞株Hela和人胃癌细胞SGC-7901的体外抑制活性。结果表明:化合物3b和3e对Hela的抑制作用较好,IC 50分别为18.2和17.4μmol·L^-1。展开更多
An one pot method is used for the synthesis of 1,2,4,6 tetraaryl 1,4 dihydropyrazine by the reaction of phenacyl bromides with arylamines.This synthetic method provides an easier and simpler access to this kind of com...An one pot method is used for the synthesis of 1,2,4,6 tetraaryl 1,4 dihydropyrazine by the reaction of phenacyl bromides with arylamines.This synthetic method provides an easier and simpler access to this kind of compounds as compared with the that in reference.展开更多
文摘以天然产物白杨素为原料,与多种α-溴代苯乙酮反应制得6种7-(2-羰基-2-苯基)乙氧基白杨素衍生物(2a^2f);2a^2f与盐酸羟胺进行肟化反应,合成了6种新型的Z-构型7-(2-羟亚胺-2-苯基)乙氧基白杨素衍生物(3a^3f),其结构经1 H NMR,13 C NMR,IR和HR-MS(ESI)表征。采用MTT法测试了3a^3f对人宫颈癌细胞株Hela和人胃癌细胞SGC-7901的体外抑制活性。结果表明:化合物3b和3e对Hela的抑制作用较好,IC 50分别为18.2和17.4μmol·L^-1。
文摘An one pot method is used for the synthesis of 1,2,4,6 tetraaryl 1,4 dihydropyrazine by the reaction of phenacyl bromides with arylamines.This synthetic method provides an easier and simpler access to this kind of compounds as compared with the that in reference.
