目的Meta分析IVF/ICSI助孕的不孕妇女中单角子宫患者与正常子宫患者临床妊娠结局差异。方法检索建库起至2019年8月10日PubMed、Embase、Wed of Science、Cochrane、知网、万方数据库,收集比较单角子宫与正常子宫行IVF/ICSI助孕治疗的不...目的Meta分析IVF/ICSI助孕的不孕妇女中单角子宫患者与正常子宫患者临床妊娠结局差异。方法检索建库起至2019年8月10日PubMed、Embase、Wed of Science、Cochrane、知网、万方数据库,收集比较单角子宫与正常子宫行IVF/ICSI助孕治疗的不孕患者妊娠结局,包括妊娠率、流产率、宫外孕率等。筛选并分析文献,采用Revman5.3软件进行Meta分析。结果最终纳入6篇符合标准的文献,结果显示,与正常子宫组相比,单角子宫组的妊娠率、活产率、平均分娩孕周、足月产率、新生儿平均体重等均降低,低体重新生儿例数、极低体重新生儿例数、流产率及早产率等均升高,差异具有统计学意义(P<0.05);两组临床妊娠率、持续妊娠率、种植率、宫外孕率比较,差异无统计学意义(P>0.05)。结论单角子宫不孕患者行IVF/ICSI治疗,与子宫正常不孕患者比较,容易出现流产、早产及新生儿体重下降等情况。展开更多
Objective: To study whether the unexpected poor ovarian responders optimization of uterine receptivity with a flexible controlled ovarian hyper stimulation protocol based on the Biophysical Profile of the Uterus, has ...Objective: To study whether the unexpected poor ovarian responders optimization of uterine receptivity with a flexible controlled ovarian hyper stimulation protocol based on the Biophysical Profile of the Uterus, has an impact on their reproductive performance. Design: Observational Prospective study. Setting(s): i) General hospital-IVF and Infertility Centre;ii) University hospital. Patient(s): 44 normogonadotrophic young women (26 - 38 yrs) with previous “unexpected” poor ovarian response underwent IVF/ICSI treatment on a protocol based on the Biophysical Profile of their uterus (Group A). The same patients were used as controls in a preceded IVF cycle on the conventional stimulation protocol. Intervention(s): None. Main outcome measure(s): Pregnancy, miscarriage and home take baby rates, amount and duration of gonadotropins required, number and quality of embryos resulted, Biophysical Profile of the Uterus score. Result(s). Treatment in Group A in comparison to Group B resulted in significantly larger number of eggs retrieved per patient, and improved fertilization rates and higher number of embryos/ET (p = 0.011, 0.010 and 0.034 respectively). Group A also demonstrated a trend for higher rates of clinical pregnancy (29.5% v.s. 15.9%), viable stage pregnancies ≥ 24 weeks (33.3% v.s. 20%) and home take babies (26.6% v.s. 16%). The amount of gonadotropins used per patient (IU) was similar in the two groups (p = 0.264). Cancellation, implantation and miscarriage rates as well as embryos quality, although superior in the treatment Group A, showed no significant difference. The number of pregnancies achieved in Group A, were directly related with the score in the Biophysical Profile of the Uterus 12 point scale. Conclusion(s): Unexpected Poor Ovarian Responders on the flexible IVF/ICSI protocol (Group A), adjusting the management according to the Biophysical Profile of their uterus (duration of stimulation, day of HCG and day of embryo transfer), had a significantly better performance in comparison to the Gro展开更多
目的:研究行体外受精的U4b型单角子宫不孕症患者与正常子宫不孕症患者的实验室及临床结局的差异及早产的相关因素分析。方法:选取2015年6月至2017年6月在郑州大学第一附属医院生殖医学中心行体外受精-胚胎移植的U4b型单角子宫不孕症患者...目的:研究行体外受精的U4b型单角子宫不孕症患者与正常子宫不孕症患者的实验室及临床结局的差异及早产的相关因素分析。方法:选取2015年6月至2017年6月在郑州大学第一附属医院生殖医学中心行体外受精-胚胎移植的U4b型单角子宫不孕症患者134例,根据年龄、不孕类型、不孕年限、基础卵泡刺激素水平和受精方式行1∶1倾向性评分匹配同时期正常形态子宫不孕症患者134例作为对照组,比较两组患者的基本资料、促排卵后临床和实验室指标及临床结局。结果:两组患者的基本资料、扳机日激素水平、获卵数、卵母细胞成熟率、受精率、优胚率、新鲜周期临床妊娠率、流产率、活产率和累积活产率差异均无统计学意义(P>0.05)。与对照组相比,U4b型单角子宫组促性腺激素的总用量[(2014.27±671.85)IU vs(1825.56±616.76)IU]扳机日子宫内膜厚度[(10.87±2.43)mm vs(11.97±2.36)mm]、新鲜周期胚胎着床率(40.34%vs 55.10%)、活产单胎新生儿平均出生体重(3147.22 g vs 3405.69 g)差异均有统计学意义(P<0.05)。结论:U4b型单角子宫患者通过体外受精技术能够获得与正常形态子宫患者相似的累积活产率。增加早产风险的主要因素是双胎妊娠。展开更多
文摘目的Meta分析IVF/ICSI助孕的不孕妇女中单角子宫患者与正常子宫患者临床妊娠结局差异。方法检索建库起至2019年8月10日PubMed、Embase、Wed of Science、Cochrane、知网、万方数据库,收集比较单角子宫与正常子宫行IVF/ICSI助孕治疗的不孕患者妊娠结局,包括妊娠率、流产率、宫外孕率等。筛选并分析文献,采用Revman5.3软件进行Meta分析。结果最终纳入6篇符合标准的文献,结果显示,与正常子宫组相比,单角子宫组的妊娠率、活产率、平均分娩孕周、足月产率、新生儿平均体重等均降低,低体重新生儿例数、极低体重新生儿例数、流产率及早产率等均升高,差异具有统计学意义(P<0.05);两组临床妊娠率、持续妊娠率、种植率、宫外孕率比较,差异无统计学意义(P>0.05)。结论单角子宫不孕患者行IVF/ICSI治疗,与子宫正常不孕患者比较,容易出现流产、早产及新生儿体重下降等情况。
文摘Objective: To study whether the unexpected poor ovarian responders optimization of uterine receptivity with a flexible controlled ovarian hyper stimulation protocol based on the Biophysical Profile of the Uterus, has an impact on their reproductive performance. Design: Observational Prospective study. Setting(s): i) General hospital-IVF and Infertility Centre;ii) University hospital. Patient(s): 44 normogonadotrophic young women (26 - 38 yrs) with previous “unexpected” poor ovarian response underwent IVF/ICSI treatment on a protocol based on the Biophysical Profile of their uterus (Group A). The same patients were used as controls in a preceded IVF cycle on the conventional stimulation protocol. Intervention(s): None. Main outcome measure(s): Pregnancy, miscarriage and home take baby rates, amount and duration of gonadotropins required, number and quality of embryos resulted, Biophysical Profile of the Uterus score. Result(s). Treatment in Group A in comparison to Group B resulted in significantly larger number of eggs retrieved per patient, and improved fertilization rates and higher number of embryos/ET (p = 0.011, 0.010 and 0.034 respectively). Group A also demonstrated a trend for higher rates of clinical pregnancy (29.5% v.s. 15.9%), viable stage pregnancies ≥ 24 weeks (33.3% v.s. 20%) and home take babies (26.6% v.s. 16%). The amount of gonadotropins used per patient (IU) was similar in the two groups (p = 0.264). Cancellation, implantation and miscarriage rates as well as embryos quality, although superior in the treatment Group A, showed no significant difference. The number of pregnancies achieved in Group A, were directly related with the score in the Biophysical Profile of the Uterus 12 point scale. Conclusion(s): Unexpected Poor Ovarian Responders on the flexible IVF/ICSI protocol (Group A), adjusting the management according to the Biophysical Profile of their uterus (duration of stimulation, day of HCG and day of embryo transfer), had a significantly better performance in comparison to the Gro
文摘目的:研究行体外受精的U4b型单角子宫不孕症患者与正常子宫不孕症患者的实验室及临床结局的差异及早产的相关因素分析。方法:选取2015年6月至2017年6月在郑州大学第一附属医院生殖医学中心行体外受精-胚胎移植的U4b型单角子宫不孕症患者134例,根据年龄、不孕类型、不孕年限、基础卵泡刺激素水平和受精方式行1∶1倾向性评分匹配同时期正常形态子宫不孕症患者134例作为对照组,比较两组患者的基本资料、促排卵后临床和实验室指标及临床结局。结果:两组患者的基本资料、扳机日激素水平、获卵数、卵母细胞成熟率、受精率、优胚率、新鲜周期临床妊娠率、流产率、活产率和累积活产率差异均无统计学意义(P>0.05)。与对照组相比,U4b型单角子宫组促性腺激素的总用量[(2014.27±671.85)IU vs(1825.56±616.76)IU]扳机日子宫内膜厚度[(10.87±2.43)mm vs(11.97±2.36)mm]、新鲜周期胚胎着床率(40.34%vs 55.10%)、活产单胎新生儿平均出生体重(3147.22 g vs 3405.69 g)差异均有统计学意义(P<0.05)。结论:U4b型单角子宫患者通过体外受精技术能够获得与正常形态子宫患者相似的累积活产率。增加早产风险的主要因素是双胎妊娠。
