Background Surgery is regarded as the most effective treatment to relieve pain and reduce complications in chronic pancreatitis （CP）. Two major strategies exist： duodenum-preserving pancreatic head resection （DPPH...Background Surgery is regarded as the most effective treatment to relieve pain and reduce complications in chronic pancreatitis （CP）. Two major strategies exist： duodenum-preserving pancreatic head resection （DPPHR） and pancreatoduodenectomy （PD）. Many studies suggest that DPPHR offers advantages during surgery and in the short-term; however, the long-term effects have not been thoroughly investigated. We analyzed the long-term outcomes of DPPHR and PD, over follow-up times of at least 1 year, to determine the optimal surgical treatment for CP. Methods We systemically reviewed all CP surgical treatment reports, and only included randomized controlled trials （RCT） comparing DPPHR and PD, excluding unqualified studies using several pre-specified criteria. When multiple publications of a single trial were found, the most comprehensive current data were selected. Characteristics of the study populations and long-term postoperative outcome parameters were collected. The quality of the studies and data was analyzed using RevMan 4.2 software. Results Five trials were qualified for meta-analysis, with 261 participants in total （114 in the DPPHR group and 147 in the PD group）. There were no significant differences in the age, gender, or indications for surgery of each group. At the mean of 5.7-year （1-14 years） follow-up examination, DPPHR and PD resulted in equally effective pain relief, exocrine and endocrine function, and similar mortality rates （P 〉0.05）; however, DPPHR patients had improved global quality of life and weight gain, and reduced diarrhea and fatigue （P 〈0.05）. Conclusion DPPHR and PD result in equal pain relief, mortality, and pancreatic function; however, DPPHR provides superior long-term outcomes.展开更多
AIM:To investigate the outcomes of pancreas-sparing duodenectomy(PSD)with regional lymph node dissection vs pancreaticoduodenectomy(PD).METHODS:Between August 2001 and June 2014,228 patients with early-stage ampullary...AIM:To investigate the outcomes of pancreas-sparing duodenectomy(PSD)with regional lymph node dissection vs pancreaticoduodenectomy(PD).METHODS:Between August 2001 and June 2014,228 patients with early-stage ampullary carcinoma(Amp Ca)underwent surgical treatment(PD,n=159;PSD with regional lymph node dissection,n=69).The patients were divided into two groups:the PD group and the PSD group.Propensity scoring methods were used to select patients with similar disease statuses.A total of 138 matched cases,with 69 patients in each group,were included in the final analysis.RESULTS:The median operative time was shorter among the patients in the PSD group(435 min)compared with those in the PD group(481 min,P=0.048).The median blood loss in the PSD group was significantly less than that in the PD group.The median length of hospital stay was shorter for patients in the PSD group vs the PD group.The incidence of pancreatic fistula was higher among patients in the PD group vs the PSD group.The 1-,3-,and 5-year overall survival and disease-free survival rates for patients in the PSD group were 83%,70%,44%and 73%,61%,39%,respectively,and these values were not different than compared with those in the PD group(P=0.625).CONCLUSION:PSD with regional lymph node dissection presents an acceptable morbidity in addition to its advantages over PD.PSD may be a safe and feasible alternative to PD in the treatment of earlystage Amp Ca.展开更多
目的探讨股骨近端病变的诊断、治疗及预后。方法对2001年1月至2014年12月在我院诊治的158例股骨近端病变进行回顾性分析。恶性肿瘤36例,良性病变122例。恶性肿瘤主要采取瘤段扩大切除髋关节假体置换术。良性病变的手术治疗主要采取病变...目的探讨股骨近端病变的诊断、治疗及预后。方法对2001年1月至2014年12月在我院诊治的158例股骨近端病变进行回顾性分析。恶性肿瘤36例,良性病变122例。恶性肿瘤主要采取瘤段扩大切除髋关节假体置换术。良性病变的手术治疗主要采取病变刮除植骨内固定术,良性侵袭性肿瘤选择瘤段切除髋关节假体置换术。结果随访6~60个月,平均29个月,共19例失访。6例良性病变术后出现复发,恶性肿瘤中6例死亡,8例局部复发,6例出现肺转移。术后根据国际保肢学会(international society of limb salvage,ISOLS)功能评分,良性病变平均25.1分;恶性肿瘤平均19.7分。结论根据股骨近端病变的病理性质、病变范围选择个体化手术治疗,以减少局部病变复发,提高患者髋关节功能及改善预后。良恶性病变均可通过手术治疗获得满意的髋关节功能。展开更多
基金This study was supported by grants from the National Natural Science Foundation of China （No. 30772493 and No. 81170429）.
文摘Background Surgery is regarded as the most effective treatment to relieve pain and reduce complications in chronic pancreatitis （CP）. Two major strategies exist： duodenum-preserving pancreatic head resection （DPPHR） and pancreatoduodenectomy （PD）. Many studies suggest that DPPHR offers advantages during surgery and in the short-term; however, the long-term effects have not been thoroughly investigated. We analyzed the long-term outcomes of DPPHR and PD, over follow-up times of at least 1 year, to determine the optimal surgical treatment for CP. Methods We systemically reviewed all CP surgical treatment reports, and only included randomized controlled trials （RCT） comparing DPPHR and PD, excluding unqualified studies using several pre-specified criteria. When multiple publications of a single trial were found, the most comprehensive current data were selected. Characteristics of the study populations and long-term postoperative outcome parameters were collected. The quality of the studies and data was analyzed using RevMan 4.2 software. Results Five trials were qualified for meta-analysis, with 261 participants in total （114 in the DPPHR group and 147 in the PD group）. There were no significant differences in the age, gender, or indications for surgery of each group. At the mean of 5.7-year （1-14 years） follow-up examination, DPPHR and PD resulted in equally effective pain relief, exocrine and endocrine function, and similar mortality rates （P 〉0.05）; however, DPPHR patients had improved global quality of life and weight gain, and reduced diarrhea and fatigue （P 〈0.05）. Conclusion DPPHR and PD result in equal pain relief, mortality, and pancreatic function; however, DPPHR provides superior long-term outcomes.
基金Supported by National Natural Science Foundation of China,No.81170453 and No.81301025Tianjin City High School Science and Technology Fund Planning Project,No.20120118
文摘AIM:To investigate the outcomes of pancreas-sparing duodenectomy(PSD)with regional lymph node dissection vs pancreaticoduodenectomy(PD).METHODS:Between August 2001 and June 2014,228 patients with early-stage ampullary carcinoma(Amp Ca)underwent surgical treatment(PD,n=159;PSD with regional lymph node dissection,n=69).The patients were divided into two groups:the PD group and the PSD group.Propensity scoring methods were used to select patients with similar disease statuses.A total of 138 matched cases,with 69 patients in each group,were included in the final analysis.RESULTS:The median operative time was shorter among the patients in the PSD group(435 min)compared with those in the PD group(481 min,P=0.048).The median blood loss in the PSD group was significantly less than that in the PD group.The median length of hospital stay was shorter for patients in the PSD group vs the PD group.The incidence of pancreatic fistula was higher among patients in the PD group vs the PSD group.The 1-,3-,and 5-year overall survival and disease-free survival rates for patients in the PSD group were 83%,70%,44%and 73%,61%,39%,respectively,and these values were not different than compared with those in the PD group(P=0.625).CONCLUSION:PSD with regional lymph node dissection presents an acceptable morbidity in addition to its advantages over PD.PSD may be a safe and feasible alternative to PD in the treatment of earlystage Amp Ca.
文摘目的探讨股骨近端病变的诊断、治疗及预后。方法对2001年1月至2014年12月在我院诊治的158例股骨近端病变进行回顾性分析。恶性肿瘤36例,良性病变122例。恶性肿瘤主要采取瘤段扩大切除髋关节假体置换术。良性病变的手术治疗主要采取病变刮除植骨内固定术,良性侵袭性肿瘤选择瘤段切除髋关节假体置换术。结果随访6~60个月,平均29个月,共19例失访。6例良性病变术后出现复发,恶性肿瘤中6例死亡,8例局部复发,6例出现肺转移。术后根据国际保肢学会(international society of limb salvage,ISOLS)功能评分,良性病变平均25.1分;恶性肿瘤平均19.7分。结论根据股骨近端病变的病理性质、病变范围选择个体化手术治疗,以减少局部病变复发,提高患者髋关节功能及改善预后。良恶性病变均可通过手术治疗获得满意的髋关节功能。
