This is first report about the simultaneous over-expression of both Insulin-like growth factor (IGF- I ) and its receptor (IGF- I R) at mRNA level in human primary hepatic Cancer (PHC). In 10 PHC samples from China, I...This is first report about the simultaneous over-expression of both Insulin-like growth factor (IGF- I ) and its receptor (IGF- I R) at mRNA level in human primary hepatic Cancer (PHC). In 10 PHC samples from China, IGF-I and IGF- I R were both over-expressed, whereas only a background signal was detected in normal liver. In 5 pairs of PHC and its non- tumorous adjacent liver tissues from South Africa, IGF- I and IGF- I R were also over-expressed in PHC. mRNA expression of IGF- I in all 5 cases and IGF- I R in 4 of 5 cases were higher in cancer than non- tumorous adjacent liver tissues. These results strongly implicate that an autocrine and/ or paracrine mechanism might be Involved in formation and progression of PHC.展开更多
目的探究同期行心脏瓣膜术与冠状动脉旁路移植术治疗心脏瓣膜病患者对其心肌损伤及炎症因子水平的影响。方法随机选取2019年3月—2022年7月徐州医科大学附属医院收治的90例心脏瓣膜病患者为研究对象,依据随机数表法分为非同期组与同期组...目的探究同期行心脏瓣膜术与冠状动脉旁路移植术治疗心脏瓣膜病患者对其心肌损伤及炎症因子水平的影响。方法随机选取2019年3月—2022年7月徐州医科大学附属医院收治的90例心脏瓣膜病患者为研究对象,依据随机数表法分为非同期组与同期组,每组45例,非同期组采用心脏瓣膜术与冠状动脉旁路移植术不同期手术治疗,同期组采用心脏瓣膜术联合冠状动脉旁路移植术同期手术治疗。对比两组患者术后恢复情况、治疗前后心肌损伤指标、炎症因子水平以及心功能指标。结果术后,同期组的呼吸机使用时间(65.62±10.77)h、重症加强护理病房(intensive care unit,ICU)时间(6.85±1.47)d、住院时间(15.86±3.64)d均短于非同期组,差异有统计学意义(t=12.222、19.418、9.825,P<0.05)。同期组心肌肌钙蛋白I、N末端脑钠肽前体、血清肌酸激酶同功酶水平均低于非同期组,差异有统计学意义(P<0.05)。同期组白介素-6、超敏C反应蛋白、肿瘤坏死因子-α水平均低于非同期组,差异有统计学意义(P<0.05)。同期组的左心室射血分数高于非同期组,心胸比、左心室舒张末期内径低于非同期组,差异有统计学意义(P<0.05)。结论心脏瓣膜病患者实施同期行心脏瓣膜术与冠状动脉旁路移植术治疗,可以缩短呼吸机使用时间、住院时间等,改善其心肌受损情况,降低其体内的炎症因子水平,稳定患者心功能,对患者病情恢复有积极影响。展开更多
文摘This is first report about the simultaneous over-expression of both Insulin-like growth factor (IGF- I ) and its receptor (IGF- I R) at mRNA level in human primary hepatic Cancer (PHC). In 10 PHC samples from China, IGF-I and IGF- I R were both over-expressed, whereas only a background signal was detected in normal liver. In 5 pairs of PHC and its non- tumorous adjacent liver tissues from South Africa, IGF- I and IGF- I R were also over-expressed in PHC. mRNA expression of IGF- I in all 5 cases and IGF- I R in 4 of 5 cases were higher in cancer than non- tumorous adjacent liver tissues. These results strongly implicate that an autocrine and/ or paracrine mechanism might be Involved in formation and progression of PHC.
文摘目的探究同期行心脏瓣膜术与冠状动脉旁路移植术治疗心脏瓣膜病患者对其心肌损伤及炎症因子水平的影响。方法随机选取2019年3月—2022年7月徐州医科大学附属医院收治的90例心脏瓣膜病患者为研究对象,依据随机数表法分为非同期组与同期组,每组45例,非同期组采用心脏瓣膜术与冠状动脉旁路移植术不同期手术治疗,同期组采用心脏瓣膜术联合冠状动脉旁路移植术同期手术治疗。对比两组患者术后恢复情况、治疗前后心肌损伤指标、炎症因子水平以及心功能指标。结果术后,同期组的呼吸机使用时间(65.62±10.77)h、重症加强护理病房(intensive care unit,ICU)时间(6.85±1.47)d、住院时间(15.86±3.64)d均短于非同期组,差异有统计学意义(t=12.222、19.418、9.825,P<0.05)。同期组心肌肌钙蛋白I、N末端脑钠肽前体、血清肌酸激酶同功酶水平均低于非同期组,差异有统计学意义(P<0.05)。同期组白介素-6、超敏C反应蛋白、肿瘤坏死因子-α水平均低于非同期组,差异有统计学意义(P<0.05)。同期组的左心室射血分数高于非同期组,心胸比、左心室舒张末期内径低于非同期组,差异有统计学意义(P<0.05)。结论心脏瓣膜病患者实施同期行心脏瓣膜术与冠状动脉旁路移植术治疗,可以缩短呼吸机使用时间、住院时间等,改善其心肌受损情况,降低其体内的炎症因子水平,稳定患者心功能,对患者病情恢复有积极影响。
