Following are the comments for the queries raised by Prof. Pawel E. Tomaszewski on our published paper entitled ＂Structural, Optical, and Electrical Properties of Zn-Doped CdO Thin Films Fabricated by a Simplified Sp...Following are the comments for the queries raised by Prof. Pawel E. Tomaszewski on our published paper entitled ＂Structural, Optical, and Electrical Properties of Zn-Doped CdO Thin Films Fabricated by a Simplified Spray Pyrolysis Technique＂ by K. Usharani and A.R. Balu published in Acta Metall. Sin.展开更多
Data mining has the potential to provide information for improving clinical acupuncture strategies by uncovering hidden rules between acupuncture manipulation and therapeutic effects in a data set. In this study, we p...Data mining has the potential to provide information for improving clinical acupuncture strategies by uncovering hidden rules between acupuncture manipulation and therapeutic effects in a data set. In this study, we performed acupuncture on 30 patients with hemiplegia due to acute ischemic stroke. All participants were pre-screened to ensure that they exhibited immediate responses to acupuncture. We used a twirling reinforcing acupuncture manipulation at the specific lines between the bilateral Baihui（GV20） and Taiyang（EX-HN5）. We collected neurologic deficit score, simplified Fugl-Meyer assessment score, muscle strength of the proximal and distal hemiplegic limbs, ratio of the maximal H-reflex to the maximal M-wave（Hmax/Mmax）, muscle tension at baseline and immediately after treatment, and the syndromes of traditional Chinese medicine at baseline. We then conducted data mining using an association algorithm and an artificial neural network backpropagation algorithm. We found that the twirling reinforcing manipulation had no obvious therapeutic difference in traditional Chinese medicine syndromes of ＂Deficiency and Excess＂. The change in the muscle strength of the upper distal and lower proximal limbs was one of the main factors affecting the immediate change in Fugl-Meyer scores. Additionally, we found a positive correlation between the muscle tension change of the upper limb and Hmax/Mmax immediate change, and both positive and negative correlations existed between the muscle tension change of the lower limb and immediate Hmax/Mmax change. Additionally, when the difference value of muscle tension for the upper and lower limbs was 〉 0 or 〈 0, the difference value of Hmax/Mmax was correspondingly positive or negative, indicating the scalp acupuncture has a bidirectional effect on muscle tension in hemiplegic limbs. Therefore, acupuncture with twirling reinforcing manipulation has distinct effects on acute ischemic stroke patients with different symptoms or stages of disease. Improved muscle te展开更多
The class 2 clustered regularly interspaced short palindromic repeat （CRISPR） systems have been widely used for simultaneous modification of multiple loci in plants. Traditionally, the type II CRISPR-Cas9 or type V ...The class 2 clustered regularly interspaced short palindromic repeat （CRISPR） systems have been widely used for simultaneous modification of multiple loci in plants. Traditionally, the type II CRISPR-Cas9 or type V CRISPR-Cpfl （also known as Cas12a） system is a two-component transcriptional unit （TCTU） in which the Cas9 or Cpf1 protein is expressed from an RNA polymerase （pol） II promoter, whereas the single guide RNA （sgRNA） is typically expressed from a Pol III promoter, such as U6 or U3 promoter.展开更多
A simplified numerical model of groundwater and solute transport is developed. At large scale area there exists a big spatial scale difference between horizontal and vertical length scales. In the resultant model, the...A simplified numerical model of groundwater and solute transport is developed. At large scale area there exists a big spatial scale difference between horizontal and vertical length scales. In the resultant model, the seepage region is particularly divided into several virtual layers along the z direction and vertical 1-D columns covering x-y 2-D area according to stratum properties. The numerical algorithm is replacing the full 3-D water and mass balance analysis as the 2-D Galerkin finite element method in x- and y-directions and 1-D finite differential approach in the z direction. The reasonable method of giving minimum thickness is successfully used to handle transient change of water table, drying cells and problem of rewetting. The solution of the simplified model is preconditioned conjugate gradient and ORTHOMIN method. The validity of the developed 3-D groundwater model is tested with the typical pumping and backwater scenarios. Results of water balance of the computed example reveal the model computation reliability. Based on a representative 3-D pollution case, the solute transport module is tested against computing results using the MT3DMS. The capability and high efficiency to predict non-stationary situations of free groundwater surface and solute plume in regional scale problem is quantitatively investigated. It is shown that the proposed model is computationally effective.展开更多
In recent years, precast segmental concrete bridge columns became prevalent because of the benefits of accelerated construction, low environmental impact, high quality and low life cycle costs. The lack of a detailed ...In recent years, precast segmental concrete bridge columns became prevalent because of the benefits of accelerated construction, low environmental impact, high quality and low life cycle costs. The lack of a detailed configuration and appropriate design procedure to ensure a comparable performance with monolithic construction has impeded this structural system from being widely used in areas of high seismicity. In this study, precast segmental bridge column cyclic loading tests were conducted to investigate the performance of unbonded post-tensioned segmental bridge columns. One monolithic and two precast segmental columns were tested. The preeast segmental column exhibited minor damage and small residual displacement after the maximum 7% cyclic drift; energy dissipation （ED） can be enhanced byadding ED bars. The experimental results were modeled by a simplified pushover method （SPOM）, as well as a fiber model （FIBM） finite element method. Forty-five cases of columns with different aspect ratios, axial load ratios and ED bar ratios were analyzed with the SPOM and FIBM, respectively. Using these parametric results, a simplified design method was suggested by regressive analysis. Satisfactory correlation was found between the experimental results and the simplified design method for preeast segmental columns with different design parameters.展开更多
On-line estimation of unmeasurable biological variables is important in fermentation processes,directly influencing the optimal control performance of the fermentation system as well as the quality and yield of the ta...On-line estimation of unmeasurable biological variables is important in fermentation processes,directly influencing the optimal control performance of the fermentation system as well as the quality and yield of the targeted product.In this study,a novel strategy for state estimation of fed-batch fermentation process is proposed.By combining a simple and reliable mechanistic dynamic model with the sample-based regressive measurement model,a state space model is developed.An improved algorithm,swarm energy conservation particle swarm optimization(SECPSO) ,is presented for the parameter identification in the mechanistic model,and the support vector machines(SVM) method is adopted to establish the nonlinear measurement model.The unscented Kalman filter(UKF) is designed for the state space model to reduce the disturbances of the noises in the fermentation process.The proposed on-line estimation method is demonstrated by the simulation experiments of a penicillin fed-batch fermentation process.展开更多
It is very important to develop a universal soil model with higher simplicity and more accuracy, which can be widely applied to very general cases such as wet or dry soil, frozen or unfrozen soil and homogeneous or he...It is very important to develop a universal soil model with higher simplicity and more accuracy, which can be widely applied to very general cases such as wet or dry soil, frozen or unfrozen soil and homogeneous or heterogeneous soil. Firstly in this study, based on analysis of both magnitude order and the numerical simulation results, the universal and simplified soil model (USSM) coupling heat and mass transport processes is developed. Secondly, in order to avoid the greater uncertainty caused by the phase change term in numerical iteration process for the model solution obtaining, new version of the universal simplified soil model (NUSSM) is further derived through variables transformation, and accordingly a more efficient numerical scheme for the new version is designed well. The simulation results from the NUSSM agree with the results from more complicated and accurate soil model very well, also reasonably reproduce the observed data under widely real conditions. The new version model, because of its simplicity, will match for the development of land surface model.展开更多
Based on reasonable assumptions that simplified the calculational model,a simple and practical method was proposed to calculate the post-construction settlement of high-speed railway bridge pile foundation by using th...Based on reasonable assumptions that simplified the calculational model,a simple and practical method was proposed to calculate the post-construction settlement of high-speed railway bridge pile foundation by using the Mesri creep model to describe the soil characteristics and the Mindlin-Geddes method considering pile diameter to calculate the vertical additional stress of pile bottom.A program named CPPS was designed for this method to calculate the post-construction settlement of a high-speed railway bridge pile foundation.The result indicates that the post-construction settlement in 100 years meets the requirements of the engineering specifications,and in the first two decades,the post-construction settlement is about 80% of its total settlement,while the settlement in the rest eighty years tends to be stable.Compared with the measured settlement after laying railway tracks,the calculational result is closed to that of the measured,and the results are conservative with a high computational accuracy.It is noted that the method can be used to calculate the post-construction settlement for the preliminary design of high-speed railway bridge pile foundation.展开更多
In order to study the differences in vertical component between onshore and offshore motions,the vertical-to-horizontal peak ground acceleration ratio(V/H PGA ratio) and vertical-to-horizontal response spectral ratio(...In order to study the differences in vertical component between onshore and offshore motions,the vertical-to-horizontal peak ground acceleration ratio(V/H PGA ratio) and vertical-to-horizontal response spectral ratio(V/H) were investigated using the ground motion recordings from the K-NET network and the seafloor earthquake measuring system(SEMS).The results indicate that the vertical component of offshore motions is lower than that of onshore motions.The V/H PGA ratio of acceleration time histories at offshore stations is about 50%of the ratio at onshore stations.The V/H for offshore ground motions is lower than that for onshore motions,especially for periods less than 0.8 s.Furthermore,based on the results in statistical analysis for offshore recordings in the K-NET,the simplified V/H design equations for offshore motions in minor and moderate earthquakes are proposed for seismic analysis of offshore structures.展开更多
文摘Following are the comments for the queries raised by Prof. Pawel E. Tomaszewski on our published paper entitled ＂Structural, Optical, and Electrical Properties of Zn-Doped CdO Thin Films Fabricated by a Simplified Spray Pyrolysis Technique＂ by K. Usharani and A.R. Balu published in Acta Metall. Sin.
基金supported by a grant from the Supporting Program of the"Eleventh Five-year Plan"for Science&Technology Research of China,Ministry of Science and Technology of China,No.2006BAI12B02a grant from the Scientific Research Fund for Talent Introduction in the Gansu University of Chinese Medicine of China,No.2012-11
文摘Data mining has the potential to provide information for improving clinical acupuncture strategies by uncovering hidden rules between acupuncture manipulation and therapeutic effects in a data set. In this study, we performed acupuncture on 30 patients with hemiplegia due to acute ischemic stroke. All participants were pre-screened to ensure that they exhibited immediate responses to acupuncture. We used a twirling reinforcing acupuncture manipulation at the specific lines between the bilateral Baihui（GV20） and Taiyang（EX-HN5）. We collected neurologic deficit score, simplified Fugl-Meyer assessment score, muscle strength of the proximal and distal hemiplegic limbs, ratio of the maximal H-reflex to the maximal M-wave（Hmax/Mmax）, muscle tension at baseline and immediately after treatment, and the syndromes of traditional Chinese medicine at baseline. We then conducted data mining using an association algorithm and an artificial neural network backpropagation algorithm. We found that the twirling reinforcing manipulation had no obvious therapeutic difference in traditional Chinese medicine syndromes of ＂Deficiency and Excess＂. The change in the muscle strength of the upper distal and lower proximal limbs was one of the main factors affecting the immediate change in Fugl-Meyer scores. Additionally, we found a positive correlation between the muscle tension change of the upper limb and Hmax/Mmax immediate change, and both positive and negative correlations existed between the muscle tension change of the lower limb and immediate Hmax/Mmax change. Additionally, when the difference value of muscle tension for the upper and lower limbs was 〉 0 or 〈 0, the difference value of Hmax/Mmax was correspondingly positive or negative, indicating the scalp acupuncture has a bidirectional effect on muscle tension in hemiplegic limbs. Therefore, acupuncture with twirling reinforcing manipulation has distinct effects on acute ischemic stroke patients with different symptoms or stages of disease. Improved muscle te
文摘The class 2 clustered regularly interspaced short palindromic repeat （CRISPR） systems have been widely used for simultaneous modification of multiple loci in plants. Traditionally, the type II CRISPR-Cas9 or type V CRISPR-Cpfl （also known as Cas12a） system is a two-component transcriptional unit （TCTU） in which the Cas9 or Cpf1 protein is expressed from an RNA polymerase （pol） II promoter, whereas the single guide RNA （sgRNA） is typically expressed from a Pol III promoter, such as U6 or U3 promoter.
基金supported by the National Science Fund for Distinguished Young Scholars(Grant No.40701071)
文摘A simplified numerical model of groundwater and solute transport is developed. At large scale area there exists a big spatial scale difference between horizontal and vertical length scales. In the resultant model, the seepage region is particularly divided into several virtual layers along the z direction and vertical 1-D columns covering x-y 2-D area according to stratum properties. The numerical algorithm is replacing the full 3-D water and mass balance analysis as the 2-D Galerkin finite element method in x- and y-directions and 1-D finite differential approach in the z direction. The reasonable method of giving minimum thickness is successfully used to handle transient change of water table, drying cells and problem of rewetting. The solution of the simplified model is preconditioned conjugate gradient and ORTHOMIN method. The validity of the developed 3-D groundwater model is tested with the typical pumping and backwater scenarios. Results of water balance of the computed example reveal the model computation reliability. Based on a representative 3-D pollution case, the solute transport module is tested against computing results using the MT3DMS. The capability and high efficiency to predict non-stationary situations of free groundwater surface and solute plume in regional scale problem is quantitatively investigated. It is shown that the proposed model is computationally effective.
基金National Natural Science Foundation of China under Grants Nos.51208268 and 51178429K.C.Wong Magna Fund in Ningbo University+1 种基金Transportation Science and Technology Project of Ningbo City under Grant No.201507Natural Science Foundation of Ningbo City under Grant No.2015A610293
文摘In recent years, precast segmental concrete bridge columns became prevalent because of the benefits of accelerated construction, low environmental impact, high quality and low life cycle costs. The lack of a detailed configuration and appropriate design procedure to ensure a comparable performance with monolithic construction has impeded this structural system from being widely used in areas of high seismicity. In this study, precast segmental bridge column cyclic loading tests were conducted to investigate the performance of unbonded post-tensioned segmental bridge columns. One monolithic and two precast segmental columns were tested. The preeast segmental column exhibited minor damage and small residual displacement after the maximum 7% cyclic drift; energy dissipation （ED） can be enhanced byadding ED bars. The experimental results were modeled by a simplified pushover method （SPOM）, as well as a fiber model （FIBM） finite element method. Forty-five cases of columns with different aspect ratios, axial load ratios and ED bar ratios were analyzed with the SPOM and FIBM, respectively. Using these parametric results, a simplified design method was suggested by regressive analysis. Satisfactory correlation was found between the experimental results and the simplified design method for preeast segmental columns with different design parameters.
基金Supported by the National Natural Science Foundation of China（20476007 20676013）
文摘On-line estimation of unmeasurable biological variables is important in fermentation processes,directly influencing the optimal control performance of the fermentation system as well as the quality and yield of the targeted product.In this study,a novel strategy for state estimation of fed-batch fermentation process is proposed.By combining a simple and reliable mechanistic dynamic model with the sample-based regressive measurement model,a state space model is developed.An improved algorithm,swarm energy conservation particle swarm optimization(SECPSO) ,is presented for the parameter identification in the mechanistic model,and the support vector machines(SVM) method is adopted to establish the nonlinear measurement model.The unscented Kalman filter(UKF) is designed for the state space model to reduce the disturbances of the noises in the fermentation process.The proposed on-line estimation method is demonstrated by the simulation experiments of a penicillin fed-batch fermentation process.
基金the National Natural Science Foundation of China (Grant Nos. 40575043 and 40233034)the Knowledge Innovation Program of the Chinese Academy of Sciences (Grant No. KZCX3-SW-229)
文摘It is very important to develop a universal soil model with higher simplicity and more accuracy, which can be widely applied to very general cases such as wet or dry soil, frozen or unfrozen soil and homogeneous or heterogeneous soil. Firstly in this study, based on analysis of both magnitude order and the numerical simulation results, the universal and simplified soil model (USSM) coupling heat and mass transport processes is developed. Secondly, in order to avoid the greater uncertainty caused by the phase change term in numerical iteration process for the model solution obtaining, new version of the universal simplified soil model (NUSSM) is further derived through variables transformation, and accordingly a more efficient numerical scheme for the new version is designed well. The simulation results from the NUSSM agree with the results from more complicated and accurate soil model very well, also reasonably reproduce the observed data under widely real conditions. The new version model, because of its simplicity, will match for the development of land surface model.
基金Projects(2009G008-B,2010G018-E-3) supported by Key Projects of China Railway Ministry Science and Technology Research and Development ProgramProject(CX2013B076) supported by Hunan Provincial Innovation Foundation For Postgraduate,China
文摘Based on reasonable assumptions that simplified the calculational model,a simple and practical method was proposed to calculate the post-construction settlement of high-speed railway bridge pile foundation by using the Mesri creep model to describe the soil characteristics and the Mindlin-Geddes method considering pile diameter to calculate the vertical additional stress of pile bottom.A program named CPPS was designed for this method to calculate the post-construction settlement of a high-speed railway bridge pile foundation.The result indicates that the post-construction settlement in 100 years meets the requirements of the engineering specifications,and in the first two decades,the post-construction settlement is about 80% of its total settlement,while the settlement in the rest eighty years tends to be stable.Compared with the measured settlement after laying railway tracks,the calculational result is closed to that of the measured,and the results are conservative with a high computational accuracy.It is noted that the method can be used to calculate the post-construction settlement for the preliminary design of high-speed railway bridge pile foundation.
基金Project(2011CB013605)supported by the National Basic Research Development Program of China(973 Program)Projects(51178071,51008041)supported by the National Natural Science Foundation of ChinaProject(NCET-12-0751)supported by the New Century Excellent Talents Program in University of Ministry of Education of China
文摘In order to study the differences in vertical component between onshore and offshore motions,the vertical-to-horizontal peak ground acceleration ratio(V/H PGA ratio) and vertical-to-horizontal response spectral ratio(V/H) were investigated using the ground motion recordings from the K-NET network and the seafloor earthquake measuring system(SEMS).The results indicate that the vertical component of offshore motions is lower than that of onshore motions.The V/H PGA ratio of acceleration time histories at offshore stations is about 50%of the ratio at onshore stations.The V/H for offshore ground motions is lower than that for onshore motions,especially for periods less than 0.8 s.Furthermore,based on the results in statistical analysis for offshore recordings in the K-NET,the simplified V/H design equations for offshore motions in minor and moderate earthquakes are proposed for seismic analysis of offshore structures.
