Because of their strong proliferative capacity and multi-potency, placenta-derived mesenchymal stem cells have gained interest as a cell source in the field of nerve damage repair. In the present study, human placenta...Because of their strong proliferative capacity and multi-potency, placenta-derived mesenchymal stem cells have gained interest as a cell source in the field of nerve damage repair. In the present study, human placenta-derived mesenchymal stem ceils were induced to differentiate into neural stem cells, which were then transplanted into the spinal cord after local spinal cord injury in rats. The motor functional recovery and pathological changes in the injured spinal cord were observed for 3 successive weeks. The results showed that human placenta-derived mesenchymal stem cells can differentiate into neuron-like cells and that induced neural stem cells contribute to the restoration of injured spinal cord without causing transplant rejection. Thus, these cells promote the recovery of motor and sensory functions in a rat model of spinal cord injury. Therefore, human placenta-derived mesenchymal stem cells may be useful as seed cells during the repair of spinal cord injury.展开更多
目的:比较小腿远端蒂穿支皮瓣与股前外侧游离穿支皮瓣对足踝部软组织缺损的修复效果。方法:按照随机数字法将2014年1月-2018年1月笔者医院收治的60例足踝部软组织缺损患者分为带蒂皮瓣组与游离皮瓣组,每组30例。带蒂皮瓣组与游离皮瓣组...目的:比较小腿远端蒂穿支皮瓣与股前外侧游离穿支皮瓣对足踝部软组织缺损的修复效果。方法:按照随机数字法将2014年1月-2018年1月笔者医院收治的60例足踝部软组织缺损患者分为带蒂皮瓣组与游离皮瓣组,每组30例。带蒂皮瓣组与游离皮瓣组患者分别采用小腿远端蒂穿支皮瓣与股前外侧游离穿支皮瓣修进行修复。术后随访12个月,比较两组手术效果[皮瓣切取面积、手术时间、皮瓣愈合时间、两点辨别觉(two-point discrimination,2PD)、皮瓣成活率、外形满意度],采用美国矫形外科足踝协会(American society of orthopaedic foot and ankle surgery,AOFAS)踝-后足评分评估两组患者的足踝功能情况,采用英国医学研究会(British medical research council,BMRC)感觉功能恢复分级评价标准对两组患者的感觉功能进行评价。结果:带蒂皮瓣组的皮瓣切取面积明显小于游离皮瓣组[(109.25±24.33)cm2 vs(214.78±45.62)cm2],手术时间明显短于游离皮瓣组[(74.17±21.44)min vs(315.23±34.42)min],差异均有统计学意义(P<0.05)。两组皮瓣愈合时间、皮瓣成活率、外形满意度、AOFAS踝-后足评分及感觉功能分级比较差异无统计学意义(P>0.05)。结论:两种皮瓣对足踝部软组织缺损的修复效果相当,应对患者情况进行综合评估,选择合适的皮瓣。展开更多
基金supported by a grant from the Scientific Research Program of Liaoning Provincial Science and Technology Ministry in China,No.2012225014
文摘Because of their strong proliferative capacity and multi-potency, placenta-derived mesenchymal stem cells have gained interest as a cell source in the field of nerve damage repair. In the present study, human placenta-derived mesenchymal stem ceils were induced to differentiate into neural stem cells, which were then transplanted into the spinal cord after local spinal cord injury in rats. The motor functional recovery and pathological changes in the injured spinal cord were observed for 3 successive weeks. The results showed that human placenta-derived mesenchymal stem cells can differentiate into neuron-like cells and that induced neural stem cells contribute to the restoration of injured spinal cord without causing transplant rejection. Thus, these cells promote the recovery of motor and sensory functions in a rat model of spinal cord injury. Therefore, human placenta-derived mesenchymal stem cells may be useful as seed cells during the repair of spinal cord injury.
文摘目的:比较小腿远端蒂穿支皮瓣与股前外侧游离穿支皮瓣对足踝部软组织缺损的修复效果。方法:按照随机数字法将2014年1月-2018年1月笔者医院收治的60例足踝部软组织缺损患者分为带蒂皮瓣组与游离皮瓣组,每组30例。带蒂皮瓣组与游离皮瓣组患者分别采用小腿远端蒂穿支皮瓣与股前外侧游离穿支皮瓣修进行修复。术后随访12个月,比较两组手术效果[皮瓣切取面积、手术时间、皮瓣愈合时间、两点辨别觉(two-point discrimination,2PD)、皮瓣成活率、外形满意度],采用美国矫形外科足踝协会(American society of orthopaedic foot and ankle surgery,AOFAS)踝-后足评分评估两组患者的足踝功能情况,采用英国医学研究会(British medical research council,BMRC)感觉功能恢复分级评价标准对两组患者的感觉功能进行评价。结果:带蒂皮瓣组的皮瓣切取面积明显小于游离皮瓣组[(109.25±24.33)cm2 vs(214.78±45.62)cm2],手术时间明显短于游离皮瓣组[(74.17±21.44)min vs(315.23±34.42)min],差异均有统计学意义(P<0.05)。两组皮瓣愈合时间、皮瓣成活率、外形满意度、AOFAS踝-后足评分及感觉功能分级比较差异无统计学意义(P>0.05)。结论:两种皮瓣对足踝部软组织缺损的修复效果相当,应对患者情况进行综合评估,选择合适的皮瓣。
