Background Pregnant women with heart disease are at high risk. Studies of risk factors of these patients are of great significance to improve maternal and fetal outcomes. In this paper, we try to discuss the main risk...Background Pregnant women with heart disease are at high risk. Studies of risk factors of these patients are of great significance to improve maternal and fetal outcomes. In this paper, we try to discuss the main risk factors of cardiac events in pregnant women with heart disease and to establish a risk assessment system. Methods A retrospective analysis was carried out for pregnancies in 1741 women with heart disease who delivered in Shanghai Obstetrical Cardiology Intensive Care Center between January 1993 and September 2010. A Logistic regression model was used to identify independent risk factors of cardiac events and calculate the risk index in pregnant women with heart disease. Results The composition of heart disease in pregnant women was arrhythmia （n=662, 38.00%）, congenital heart disease （CHD; n=529, 30.40%）, cardiomyopathy （n=327, 18.80%）, rheumatic heart disease （RHD; n=151, 8.70%）, and cardiopathy induced by pre-eclampsia （n=53, 3.00%）. Main cardiac events were heart failure （n=110, 6.32%）, symptomatic arrhythmia needing medication （n=43, 2.47%）, cardiac arrest （n=2, 0.11%）, syncope （n=3, 0.17%）, and maternal death （n=10, 0.57%）. Six independent risk factors to predict cardiac events in pregnant women with heart disease were cardiac events before pregnancy （heart failure, severe arrhythmia, cardiac shock, etc., P=0.000）, New York Heart Association （NYHA） class 〉11 （m=0.000）, oxygen saturation 〈90% （P=0.018）, pulmonary artery hypertention （PAH） 〉50 mmHg （P=0.025）, cyanotic heart disease without surgical correction （P=-0.015）, and reduced left ventricular systolic function （ejection fraction 〈40%, P=0.003）. Every risk factor was calculated as 1 score. The incidence of cardiac events in patients with scores 0, 1, 2, 3, and 〉4 was 2.10%, 31.61 %, 61.25%, 68.97%, and 100.00% respectively. Conclusions Pregnancy with heart disease could lead to undesirable pregnancy outcomes. The risk of cardiac events in pregnant women with h展开更多
背景与目的:肥胖被证实为增加结直肠癌的重要因素。有研究表明,无论对于男性还是女性,体质指数(body mass index,BMI)都与结肠癌的发病率有密切关系。因此,本研究探讨BMI与我国结肠癌发病的关系,为结肠癌的预防提供参考。方法:用病例-...背景与目的:肥胖被证实为增加结直肠癌的重要因素。有研究表明,无论对于男性还是女性,体质指数(body mass index,BMI)都与结肠癌的发病率有密切关系。因此,本研究探讨BMI与我国结肠癌发病的关系,为结肠癌的预防提供参考。方法:用病例-对照研究方法分析707例首次确诊的结肠癌患者和709名健康人的BMI情况,比较两组人群BMI的情况。结果:首次确诊的结肠癌患者平均BMI为(24.52±4.56)kg/m2,健康对照人群平均BMI为(23.75±3.14)kg/m2,结肠癌患者的BMI明显高于健康对照人群(t=-3.72,P<0.001)。根据性别和年龄的不同进行分组后,可以看出结肠癌患者的BMI比健康对照组高。logistic回归分析,BMI的升高是结肠癌发生的危险因素,OR值为1.059(95%CI,1.029～1.090)。结论:汉族人结肠癌的发生与BMI有关。展开更多
AIM: To clarify the association between physical activity and gastroesophageal reflux disease (GERD) in nonobese and obese people. METHODS: A Swedish population-based cross-sectional survey was conducted. Participants...AIM: To clarify the association between physical activity and gastroesophageal reflux disease (GERD) in nonobese and obese people. METHODS: A Swedish population-based cross-sectional survey was conducted. Participants aged 40-79 years were randomly selected from the Swedish Registry of the Total Population. Data on physical activity, GERD, body mass index (BMI) and the covariates age, gender, comorbidity, education, sleeping problems, and tobacco smoking were obtained using validated questionnaires. GERD was self-reported and defined as heartburn or regurgitation at least once weekly, and having at least moderate problems from such symptoms. Frequency of physical activity was categorized into three groups: (1) "high" (several times/week); (2) "intermediate" (approximately once weekly); and (3) "low" (1-3 times/mo or less). Analyses were stratified for participants with "normal weight" (BMI < 25 kg/m 2 ), "overweight" (BMI 25 to ≤ 30 kg/m 2 ) and "obese" (BMI > 30 kg/m 2 ). Multivariate logistic regression was used to calculate odds ratios (ORs) with 95% confidence intervals (CIs), adjusted for potential confounding by covariates. RESULTS: Of 6969 eligible and randomly selected individuals, 4910 (70.5%) participated. High frequency of physical activity was reported by 2463 (50%) participants, GERD was identified in 472 (10%) participants, and obesity was found in 680 (14%). There were 226 (5%) individuals with missing information about BMI. Normal weight, overweight and obese participants were similar regarding distribution of gender and tobacco smoking status, while obese participants were on average slightly older, had fewer years of education, more comorbidity, slightly more sleeping problems, lower frequency of physical activity, and higher occurrence of GERD. Among the 2146 normal-weight participants, crude point estimates indicated a decreased risk of GERD among individuals with high frequency of physical activity (OR: 0.59, 95% CI: 0.39-0.89), compared to low frequency of physical activity. However, after展开更多
文摘Background Pregnant women with heart disease are at high risk. Studies of risk factors of these patients are of great significance to improve maternal and fetal outcomes. In this paper, we try to discuss the main risk factors of cardiac events in pregnant women with heart disease and to establish a risk assessment system. Methods A retrospective analysis was carried out for pregnancies in 1741 women with heart disease who delivered in Shanghai Obstetrical Cardiology Intensive Care Center between January 1993 and September 2010. A Logistic regression model was used to identify independent risk factors of cardiac events and calculate the risk index in pregnant women with heart disease. Results The composition of heart disease in pregnant women was arrhythmia （n=662, 38.00%）, congenital heart disease （CHD; n=529, 30.40%）, cardiomyopathy （n=327, 18.80%）, rheumatic heart disease （RHD; n=151, 8.70%）, and cardiopathy induced by pre-eclampsia （n=53, 3.00%）. Main cardiac events were heart failure （n=110, 6.32%）, symptomatic arrhythmia needing medication （n=43, 2.47%）, cardiac arrest （n=2, 0.11%）, syncope （n=3, 0.17%）, and maternal death （n=10, 0.57%）. Six independent risk factors to predict cardiac events in pregnant women with heart disease were cardiac events before pregnancy （heart failure, severe arrhythmia, cardiac shock, etc., P=0.000）, New York Heart Association （NYHA） class 〉11 （m=0.000）, oxygen saturation 〈90% （P=0.018）, pulmonary artery hypertention （PAH） 〉50 mmHg （P=0.025）, cyanotic heart disease without surgical correction （P=-0.015）, and reduced left ventricular systolic function （ejection fraction 〈40%, P=0.003）. Every risk factor was calculated as 1 score. The incidence of cardiac events in patients with scores 0, 1, 2, 3, and 〉4 was 2.10%, 31.61 %, 61.25%, 68.97%, and 100.00% respectively. Conclusions Pregnancy with heart disease could lead to undesirable pregnancy outcomes. The risk of cardiac events in pregnant women with h
文摘背景与目的:肥胖被证实为增加结直肠癌的重要因素。有研究表明,无论对于男性还是女性,体质指数(body mass index,BMI)都与结肠癌的发病率有密切关系。因此,本研究探讨BMI与我国结肠癌发病的关系,为结肠癌的预防提供参考。方法:用病例-对照研究方法分析707例首次确诊的结肠癌患者和709名健康人的BMI情况,比较两组人群BMI的情况。结果:首次确诊的结肠癌患者平均BMI为(24.52±4.56)kg/m2,健康对照人群平均BMI为(23.75±3.14)kg/m2,结肠癌患者的BMI明显高于健康对照人群(t=-3.72,P<0.001)。根据性别和年龄的不同进行分组后,可以看出结肠癌患者的BMI比健康对照组高。logistic回归分析,BMI的升高是结肠癌发生的危险因素,OR值为1.059(95%CI,1.029～1.090)。结论:汉族人结肠癌的发生与BMI有关。
基金Supported by The Swedish Research CouncilThe Swedish Cancer SocietyThe Cancer Society in Stockholm
文摘AIM: To clarify the association between physical activity and gastroesophageal reflux disease (GERD) in nonobese and obese people. METHODS: A Swedish population-based cross-sectional survey was conducted. Participants aged 40-79 years were randomly selected from the Swedish Registry of the Total Population. Data on physical activity, GERD, body mass index (BMI) and the covariates age, gender, comorbidity, education, sleeping problems, and tobacco smoking were obtained using validated questionnaires. GERD was self-reported and defined as heartburn or regurgitation at least once weekly, and having at least moderate problems from such symptoms. Frequency of physical activity was categorized into three groups: (1) "high" (several times/week); (2) "intermediate" (approximately once weekly); and (3) "low" (1-3 times/mo or less). Analyses were stratified for participants with "normal weight" (BMI < 25 kg/m 2 ), "overweight" (BMI 25 to ≤ 30 kg/m 2 ) and "obese" (BMI > 30 kg/m 2 ). Multivariate logistic regression was used to calculate odds ratios (ORs) with 95% confidence intervals (CIs), adjusted for potential confounding by covariates. RESULTS: Of 6969 eligible and randomly selected individuals, 4910 (70.5%) participated. High frequency of physical activity was reported by 2463 (50%) participants, GERD was identified in 472 (10%) participants, and obesity was found in 680 (14%). There were 226 (5%) individuals with missing information about BMI. Normal weight, overweight and obese participants were similar regarding distribution of gender and tobacco smoking status, while obese participants were on average slightly older, had fewer years of education, more comorbidity, slightly more sleeping problems, lower frequency of physical activity, and higher occurrence of GERD. Among the 2146 normal-weight participants, crude point estimates indicated a decreased risk of GERD among individuals with high frequency of physical activity (OR: 0.59, 95% CI: 0.39-0.89), compared to low frequency of physical activity. However, after
