It has been shown that ions and nucleotides regulated the binding of opioid receptors. Snyder and co-workers have suggested the discrimination of agonist, mixed agonist and antagonist by using 'sodium ratio'. ...It has been shown that ions and nucleotides regulated the binding of opioid receptors. Snyder and co-workers have suggested the discrimination of agonist, mixed agonist and antagonist by using 'sodium ratio'. The bindings of agonists and some antagonists to opioid receptors were changed in the presence of GTP. Heparin sodium was a展开更多
By means of radioligand binding assay, both receptors of the malondialdehyde modified low density lipoprotein (MDA-LDL) and the oxidatively modified LDL(o-LDL) on the mouse's peritoneal macrophage (MPM) were studi...By means of radioligand binding assay, both receptors of the malondialdehyde modified low density lipoprotein (MDA-LDL) and the oxidatively modified LDL(o-LDL) on the mouse's peritoneal macrophage (MPM) were studied. The results show that there were high affinity receptors for MDA-LDL and o-LDL on the MPM and both receptors had multiplicity of configuration based on the competitive-inhibition curve or parameters IC50 and Ki, and the acetylated LDL (Ac-LDL) and dextran sulfate can both competitively inhibit MDA-LDL or oLDL binding to these receptors in some degree.It is meanful to study the scavenger receptor multiplicity and its relationship to the genesis, protection and treamtent of atherosclerosis.展开更多
家兔背部皮肤贴用东莨菪碱膜控制剂(transdermal therapeutic system of seopola-mine,TTSS),不同时间从耳缘静脉采血,立即用Sep-PAK C_(18)柱分离提取,~3H-QNB作放射配基。进行放射受体分析(RRA)。结果,我校研制的TTSS给药后72h内血药...家兔背部皮肤贴用东莨菪碱膜控制剂(transdermal therapeutic system of seopola-mine,TTSS),不同时间从耳缘静脉采血,立即用Sep-PAK C_(18)柱分离提取,~3H-QNB作放射配基。进行放射受体分析(RRA)。结果,我校研制的TTSS给药后72h内血药浓度基本稳定在0.85～1.96ng/ml,与美国CIBA公司的TTSS类似。展开更多
文摘It has been shown that ions and nucleotides regulated the binding of opioid receptors. Snyder and co-workers have suggested the discrimination of agonist, mixed agonist and antagonist by using 'sodium ratio'. The bindings of agonists and some antagonists to opioid receptors were changed in the presence of GTP. Heparin sodium was a
文摘By means of radioligand binding assay, both receptors of the malondialdehyde modified low density lipoprotein (MDA-LDL) and the oxidatively modified LDL(o-LDL) on the mouse's peritoneal macrophage (MPM) were studied. The results show that there were high affinity receptors for MDA-LDL and o-LDL on the MPM and both receptors had multiplicity of configuration based on the competitive-inhibition curve or parameters IC50 and Ki, and the acetylated LDL (Ac-LDL) and dextran sulfate can both competitively inhibit MDA-LDL or oLDL binding to these receptors in some degree.It is meanful to study the scavenger receptor multiplicity and its relationship to the genesis, protection and treamtent of atherosclerosis.
文摘家兔背部皮肤贴用东莨菪碱膜控制剂(transdermal therapeutic system of seopola-mine,TTSS),不同时间从耳缘静脉采血,立即用Sep-PAK C_(18)柱分离提取,~3H-QNB作放射配基。进行放射受体分析(RRA)。结果,我校研制的TTSS给药后72h内血药浓度基本稳定在0.85～1.96ng/ml,与美国CIBA公司的TTSS类似。
