目的探讨原发性肝细胞癌(hepatocellular carcinoma,HCC)组织中组蛋白甲基转移酶(SET and MYND domain-containing protein 2,SMYD2)表达水平与临床病理特征和预后的关系。方法回顾性选择2012年1月至2012年12月病理科保存的120例HCC组...目的探讨原发性肝细胞癌(hepatocellular carcinoma,HCC)组织中组蛋白甲基转移酶(SET and MYND domain-containing protein 2,SMYD2)表达水平与临床病理特征和预后的关系。方法回顾性选择2012年1月至2012年12月病理科保存的120例HCC组织标本作为研究对象。另选择同一患者癌旁正常组织(距离肿瘤组织>1.5 cm)作为对照。比较HCC组织及癌旁正常组织中SMYD2 mRNA相对表达量的差异。分析SMYD2表达水平与临床病理特征及预后的关系。应用单因素、多因素Cox回归分析影响HCC患者预后的危险因素。结果HCC组织中SMYD2 mRNA相对表达量为(5.23±1.18),高于癌旁正常组织中的(2.65±0.64),差异有统计学意义(P<0.05)。HCC组织中SMYD2表达水平与性别、年龄、吸烟史、嗜酒史、甲胎蛋白、HBV、HCV、肝硬化、肿瘤数量、远处转移无关(P>0.05),与分化程度、TNM分期、肿瘤直径、血管浸润有关(P<0.05)。单因素、多因素Cox回归分析结果显示,血管浸润、SMYD2阳性表达是影响HCC患者预后不良的危险因素(P<0.05)。Kaplan-Meier法生存曲线结果显示,HCC组织中SMYD2阴性表达组患者5年总生存率高于阳性表达组,差异有统计学意义(P<0.05)。结论肿瘤组织中SMYD2阳性表达不利于HCC患者预后。组织中SMYD2表达水平可作为预测HCC患者预后的重要指标。展开更多
A 66-year-old woman presented with a 2-year history of asthma has progression of dyspnea within a week, and a computed tomography (CT) revealed an endotracheal tumor at level of aortic arch. The resected tumor, measur...A 66-year-old woman presented with a 2-year history of asthma has progression of dyspnea within a week, and a computed tomography (CT) revealed an endotracheal tumor at level of aortic arch. The resected tumor, measured by 18 × 12 × 10 mm, has histologically malignant features including frank invasion with desmoplastic stroma and foci of necrosis. Presence of glycogen and mucin was confirmed by periodic acid-Schiff (PAS) and diastase PAS staining. Immunohistochemically, the tumor cells were diffusely positive for cytokeratin (CK) 7 and AE1/3, focally positive for CK5/6 and CK14, but negative for CK20. Thyroid transcription factor-1 (TTF-1), Napsin A, and SP-A, indicating lung parenchymal origin were all negative. Other muscular markers, neuroendocrine markers, renal cell carcinoma markers, and markers related to perivascular epithelioid cell tumors were all negative. Postoperative systemic examination suggests no primary tumor outside the lung. The follow up was excellent being recurrence free for 14 months in spite of the positive surgical margin by the tumor cells. This is a first report ?of rare neoplasm, clear cell carcinoma of salivary gland type, presenting as an endotracheal mass.展开更多
文摘目的探讨原发性肝细胞癌(hepatocellular carcinoma,HCC)组织中组蛋白甲基转移酶(SET and MYND domain-containing protein 2,SMYD2)表达水平与临床病理特征和预后的关系。方法回顾性选择2012年1月至2012年12月病理科保存的120例HCC组织标本作为研究对象。另选择同一患者癌旁正常组织(距离肿瘤组织>1.5 cm)作为对照。比较HCC组织及癌旁正常组织中SMYD2 mRNA相对表达量的差异。分析SMYD2表达水平与临床病理特征及预后的关系。应用单因素、多因素Cox回归分析影响HCC患者预后的危险因素。结果HCC组织中SMYD2 mRNA相对表达量为(5.23±1.18),高于癌旁正常组织中的(2.65±0.64),差异有统计学意义(P<0.05)。HCC组织中SMYD2表达水平与性别、年龄、吸烟史、嗜酒史、甲胎蛋白、HBV、HCV、肝硬化、肿瘤数量、远处转移无关(P>0.05),与分化程度、TNM分期、肿瘤直径、血管浸润有关(P<0.05)。单因素、多因素Cox回归分析结果显示,血管浸润、SMYD2阳性表达是影响HCC患者预后不良的危险因素(P<0.05)。Kaplan-Meier法生存曲线结果显示,HCC组织中SMYD2阴性表达组患者5年总生存率高于阳性表达组,差异有统计学意义(P<0.05)。结论肿瘤组织中SMYD2阳性表达不利于HCC患者预后。组织中SMYD2表达水平可作为预测HCC患者预后的重要指标。
文摘A 66-year-old woman presented with a 2-year history of asthma has progression of dyspnea within a week, and a computed tomography (CT) revealed an endotracheal tumor at level of aortic arch. The resected tumor, measured by 18 × 12 × 10 mm, has histologically malignant features including frank invasion with desmoplastic stroma and foci of necrosis. Presence of glycogen and mucin was confirmed by periodic acid-Schiff (PAS) and diastase PAS staining. Immunohistochemically, the tumor cells were diffusely positive for cytokeratin (CK) 7 and AE1/3, focally positive for CK5/6 and CK14, but negative for CK20. Thyroid transcription factor-1 (TTF-1), Napsin A, and SP-A, indicating lung parenchymal origin were all negative. Other muscular markers, neuroendocrine markers, renal cell carcinoma markers, and markers related to perivascular epithelioid cell tumors were all negative. Postoperative systemic examination suggests no primary tumor outside the lung. The follow up was excellent being recurrence free for 14 months in spite of the positive surgical margin by the tumor cells. This is a first report ?of rare neoplasm, clear cell carcinoma of salivary gland type, presenting as an endotracheal mass.
