Painful diabetic peripheral neuropathy is one of the common chronic complications of diabetes."Pain"is the most typical symptom in patients,which seriously affects their quality of life.Traditional Chinese m...Painful diabetic peripheral neuropathy is one of the common chronic complications of diabetes."Pain"is the most typical symptom in patients,which seriously affects their quality of life.Traditional Chinese medicine(TCM)treatment of the disease includes oral administration of Chinese medicine,TCM fumigation and acupuncture,etc.,which can significantly reduce the pain of patients and reduce the frequency of disease.Chinese decoctions regulate the imbalance of yin and yang in the human body through syndrome differentiation,so as to achieve the balance of yin and yang,which will then eliminate the disease.Chinese medicine fumigation make the medicine seep into the body from the skin to exert the medical effects,and nourish and dredge the meridians.There is no pain if the meridians are smooth flowing,there will be pain if the meridians are blocked,fumigation can be used alone or assisted by other treatment methods to enhance the efficacy.The characteristics of acupuncture are rapid painrelief,economic and convenient,and can quickly relieve pain for patients with low tolerance.展开更多
目的:总结393例糖尿病周围神经病变(Diabetic Peripheral Neuropathy,DPN)患者中医证候特点及分布规律。方法:应用流行病学调查方法,研究393例DPN患者中医证候分布规律,比较中医证候特点,研究生化指标糖化血红蛋白(Hemoglobin,HbA1c)、...目的:总结393例糖尿病周围神经病变(Diabetic Peripheral Neuropathy,DPN)患者中医证候特点及分布规律。方法:应用流行病学调查方法,研究393例DPN患者中医证候分布规律,比较中医证候特点,研究生化指标糖化血红蛋白(Hemoglobin,HbA1c)、空腹血糖(Glucose,GLU)、餐后2小时血糖(2 hours Postprandial Blood Glucose,2 h PBG)、高密度脂蛋白胆固醇(High Density Lipoprotein Cholesterol,HDL-C)、甘油三酯(Triglyceride,TG)、低密度脂蛋白胆固醇(Low Density Lipoprotein Cholesterol,LDL-C)、总胆固醇(Total Cholesterol,TC)、血肌酐(Creatinine,SCr)、尿素氮(Blood Urea Nitrogen,BUN)、24小时尿总蛋白(24 hours Urinary Protein Quantity,24 h UCP),与不同中医证候关系。结果:各证候出现的频率由高到低依次为气虚血瘀>气阴两虚血瘀>阴虚血瘀>肝肾阴虚>阳虚血瘀>痰瘀互结>湿热阻络。病程5年以下患者以痰瘀互结及湿热阻络等实证出现频率较高,病程5年以上患者以气阴两虚血瘀、阴虚血瘀、阳虚血瘀等虚实夹杂证出现频率较高。不同证候组间HbA1c、GLU、LDL-C、SCr、BUN、24 h UCP具有显著差异(P <0.05)。两两比较发现,与其它证候比较气阴两虚血瘀证HbA1c、SCr、BUN、24 h UCP明显升高,气虚血瘀证LDL-C、SCr、24 h UCP明显升高;在SCr、24 h UCP的证候对比中气阴两虚血瘀证与气虚血瘀证对比具有显著差异(P <0.05)。结论:DPN总属本虚标实证,血瘀是贯穿DPN发展始末的重要致病因素,气虚血瘀证及气阴两虚血瘀证是病情进展的关键证候。展开更多
基金Shaanxi Province 2020 Key Research and Development Program Project(2020SF-276)Xi'an Health Bureau Science and Technology Project(J201902018)。
文摘Painful diabetic peripheral neuropathy is one of the common chronic complications of diabetes."Pain"is the most typical symptom in patients,which seriously affects their quality of life.Traditional Chinese medicine(TCM)treatment of the disease includes oral administration of Chinese medicine,TCM fumigation and acupuncture,etc.,which can significantly reduce the pain of patients and reduce the frequency of disease.Chinese decoctions regulate the imbalance of yin and yang in the human body through syndrome differentiation,so as to achieve the balance of yin and yang,which will then eliminate the disease.Chinese medicine fumigation make the medicine seep into the body from the skin to exert the medical effects,and nourish and dredge the meridians.There is no pain if the meridians are smooth flowing,there will be pain if the meridians are blocked,fumigation can be used alone or assisted by other treatment methods to enhance the efficacy.The characteristics of acupuncture are rapid painrelief,economic and convenient,and can quickly relieve pain for patients with low tolerance.
文摘目的:总结393例糖尿病周围神经病变(Diabetic Peripheral Neuropathy,DPN)患者中医证候特点及分布规律。方法:应用流行病学调查方法,研究393例DPN患者中医证候分布规律,比较中医证候特点,研究生化指标糖化血红蛋白(Hemoglobin,HbA1c)、空腹血糖(Glucose,GLU)、餐后2小时血糖(2 hours Postprandial Blood Glucose,2 h PBG)、高密度脂蛋白胆固醇(High Density Lipoprotein Cholesterol,HDL-C)、甘油三酯(Triglyceride,TG)、低密度脂蛋白胆固醇(Low Density Lipoprotein Cholesterol,LDL-C)、总胆固醇(Total Cholesterol,TC)、血肌酐(Creatinine,SCr)、尿素氮(Blood Urea Nitrogen,BUN)、24小时尿总蛋白(24 hours Urinary Protein Quantity,24 h UCP),与不同中医证候关系。结果:各证候出现的频率由高到低依次为气虚血瘀>气阴两虚血瘀>阴虚血瘀>肝肾阴虚>阳虚血瘀>痰瘀互结>湿热阻络。病程5年以下患者以痰瘀互结及湿热阻络等实证出现频率较高,病程5年以上患者以气阴两虚血瘀、阴虚血瘀、阳虚血瘀等虚实夹杂证出现频率较高。不同证候组间HbA1c、GLU、LDL-C、SCr、BUN、24 h UCP具有显著差异(P <0.05)。两两比较发现,与其它证候比较气阴两虚血瘀证HbA1c、SCr、BUN、24 h UCP明显升高,气虚血瘀证LDL-C、SCr、24 h UCP明显升高;在SCr、24 h UCP的证候对比中气阴两虚血瘀证与气虚血瘀证对比具有显著差异(P <0.05)。结论:DPN总属本虚标实证,血瘀是贯穿DPN发展始末的重要致病因素,气虚血瘀证及气阴两虚血瘀证是病情进展的关键证候。
