Background Optical coherence tomography （OCT） is a high resolution noncontact imaging modality which can quantitatively detect the optic disc and retinal structure.This study was designed to evaluate the diagnostic ...Background Optical coherence tomography （OCT） is a high resolution noncontact imaging modality which can quantitatively detect the optic disc and retinal structure.This study was designed to evaluate the diagnostic capability of parameters of the optic disc, retinal nerve fiber layer thickness, and ganglion cell complex （GCC） using a new technology called Fourier-domain OCT （FD-OCT） for early primary open angle glaucoma （POAG） patients.Methods Two groups of patients, early perimetric damage POAG and normal subjects were included in this observational cross-sectional study.All patients underwent FD-OCT and visual field examination in addition to full ophthalmic examinations.Receiver operating characteristic curves （ROC） were studied for all parameters.The sensitivity and specificity for distinguishing between normal and early glaucomatous eyes, the areas under the receiver operating characteristic curves （AROC） and positive, negative likelihood ratios were evaluated for all the single parameters and selected combined parameters using arbitrary cutoffs.Results Thirty-four eyes of 34 early POAG patients and 42 eyes of 42 normal subjects were analyzed.Cup/disc （C/D）vertical ratio presented the best sensitivity and positive likelihood ratio for selected specificities （95% and 85%） which were 79.4% and 88.2%, 33.4 and 7.4, respectively.Among all single parameters, the C/D vertical ratio demonstrated the highest AROC which was at 0.930.The average thickness of circumpapillary RNFL on 3.45 mm showed the highest AROC among all of the peripapillary RNFL parameters.The sensitivity at selected specificity and AROC of GCC were not as high as C/D vertical ratio and RNFL AT on 3.45 mm.When the C/D vertical ratio, RNFL AT on 3.45 mm, and rim area were combined using a logistical diagnostic model, the AROC was raised to 0.949 but not significantly different from the top single parameter, C/D vertical ratio.Conclusions The key parameters obtained by FD-OCT were able to show the significant differenc展开更多
目的:探讨原发性开角型青光眼(primary open angle glaucoma,POAG)视盘旁萎缩弧β区的变化和POAG进展之间的关系。方法:本研究为回顾性病例研究。对POAG 44例66眼进行5a的随访,其基线和5a随访时的所拍摄的眼底照片用于视盘形态学的评估...目的:探讨原发性开角型青光眼(primary open angle glaucoma,POAG)视盘旁萎缩弧β区的变化和POAG进展之间的关系。方法:本研究为回顾性病例研究。对POAG 44例66眼进行5a的随访,其基线和5a随访时的所拍摄的眼底照片用于视盘形态学的评估。本研究对前后视盘旁萎缩弧β(β区)的变化和青光眼进展进行判断,并且用计算机软件测量了POAG患者基线和随访时盘沿/视盘面积比、β区/视盘面积比、垂直杯盘比。结果:基线时66眼POAG眼有48眼存在β区,其中β区扩大20眼(42%)。β区扩大组和无变化组之间基线的年龄,屈光,性别,垂直杯盘比,盘沿/视盘面积比,β区/视盘面积比之间无统计学差异。排除屈光度数大于-3.00D的眼后,19例无进展青光眼中β区扩大4例(21%),25例进展青光眼中β区扩大15例(60%),两者之间有显著统计学差异(χ2=6.67,P=0.011)。结论:POAG中有β区扩大组青光眼进展率大于无扩大组,β区的变化可能对POAG病情的进展有预测作用。展开更多
文摘Background Optical coherence tomography （OCT） is a high resolution noncontact imaging modality which can quantitatively detect the optic disc and retinal structure.This study was designed to evaluate the diagnostic capability of parameters of the optic disc, retinal nerve fiber layer thickness, and ganglion cell complex （GCC） using a new technology called Fourier-domain OCT （FD-OCT） for early primary open angle glaucoma （POAG） patients.Methods Two groups of patients, early perimetric damage POAG and normal subjects were included in this observational cross-sectional study.All patients underwent FD-OCT and visual field examination in addition to full ophthalmic examinations.Receiver operating characteristic curves （ROC） were studied for all parameters.The sensitivity and specificity for distinguishing between normal and early glaucomatous eyes, the areas under the receiver operating characteristic curves （AROC） and positive, negative likelihood ratios were evaluated for all the single parameters and selected combined parameters using arbitrary cutoffs.Results Thirty-four eyes of 34 early POAG patients and 42 eyes of 42 normal subjects were analyzed.Cup/disc （C/D）vertical ratio presented the best sensitivity and positive likelihood ratio for selected specificities （95% and 85%） which were 79.4% and 88.2%, 33.4 and 7.4, respectively.Among all single parameters, the C/D vertical ratio demonstrated the highest AROC which was at 0.930.The average thickness of circumpapillary RNFL on 3.45 mm showed the highest AROC among all of the peripapillary RNFL parameters.The sensitivity at selected specificity and AROC of GCC were not as high as C/D vertical ratio and RNFL AT on 3.45 mm.When the C/D vertical ratio, RNFL AT on 3.45 mm, and rim area were combined using a logistical diagnostic model, the AROC was raised to 0.949 but not significantly different from the top single parameter, C/D vertical ratio.Conclusions The key parameters obtained by FD-OCT were able to show the significant differenc
文摘目的:探讨原发性开角型青光眼(primary open angle glaucoma,POAG)视盘旁萎缩弧β区的变化和POAG进展之间的关系。方法:本研究为回顾性病例研究。对POAG 44例66眼进行5a的随访,其基线和5a随访时的所拍摄的眼底照片用于视盘形态学的评估。本研究对前后视盘旁萎缩弧β(β区)的变化和青光眼进展进行判断,并且用计算机软件测量了POAG患者基线和随访时盘沿/视盘面积比、β区/视盘面积比、垂直杯盘比。结果:基线时66眼POAG眼有48眼存在β区,其中β区扩大20眼(42%)。β区扩大组和无变化组之间基线的年龄,屈光,性别,垂直杯盘比,盘沿/视盘面积比,β区/视盘面积比之间无统计学差异。排除屈光度数大于-3.00D的眼后,19例无进展青光眼中β区扩大4例(21%),25例进展青光眼中β区扩大15例(60%),两者之间有显著统计学差异(χ2=6.67,P=0.011)。结论:POAG中有β区扩大组青光眼进展率大于无扩大组,β区的变化可能对POAG病情的进展有预测作用。
