目的探讨慢性阻塞性肺疾病合并2型糖尿病患者空腹血糖(FBG)、餐后2 h血糖(2 h PG)、白细胞介素-6(IL-6)、白细胞介素-8(IL-8)、肿瘤坏死因子-α(TNF-α)、干扰素-γ(IFN-γ)水平及与肺功能指标的相关性。方法选取2018年10月—2020年10...目的探讨慢性阻塞性肺疾病合并2型糖尿病患者空腹血糖(FBG)、餐后2 h血糖(2 h PG)、白细胞介素-6(IL-6)、白细胞介素-8(IL-8)、肿瘤坏死因子-α(TNF-α)、干扰素-γ(IFN-γ)水平及与肺功能指标的相关性。方法选取2018年10月—2020年10月本院收治的慢性阻塞性肺疾病合并2型糖尿病62例为观察组,单纯慢性阻塞性肺疾病62例为对照组,另选取同期在本院行健康体检且身体健康者50例为健康对照组。对比3组FBG、2 h PG、IL-6、IL-8、TNF-α、IFN-γ、用力肺活量(FVC)、一秒用力呼气容积(FEV1)、第一秒用力呼气量占用力肺活量的比例(FEV1/FVC),分析慢性阻塞性肺疾病合并2型糖尿病患者FBG、2 h PG、IL-6、IL-8、TNF-α、IFN-γ与肺功能指标的相关性,并绘制受试者工作特征(ROC)曲线分析IL-6、TNF-α、FBG检测及三者联合检测对慢性阻塞性肺疾病患者发生2型糖尿病的预测价值。结果观察组FBG、2 h PG、IL-6、IL-8、TNF-α、IFN-γ水平均高于对照组及健康对照组(P<0.05),FVC、FEV1、FEV1/FVC水平均明显低于对照组及健康对照组(P<0.05)。慢性阻塞性肺疾病合并2型糖尿病患者FBG、2 h PG、IL-6、IL-8、TNF-α、IFN-γ水平与FVC、FEV1、FEV1/FVC呈负相关(P<0.05,P<0.01)。ROC曲线分析显示,IL-6、TNF-α、FBG检测及三者联合检测的曲线下面积分别为0.862、0.824、0.817和0.972,以联合检测曲线下面积最大。结论慢性阻塞性肺疾病合并2型糖尿病患者体内血糖相关指标及炎性因子水平升高,且与患者肺功能指标呈负相关;IL-6、TNF-α及FBG联合检测可作为预测慢性阻塞性肺疾病患者发生2型糖尿病的重要指标。展开更多
BACKGROUND Obstructive sleep apnea(OSA)-hypopnea syndrome(OSAHS)has been recognized as a comorbidity of type 2 diabetes mellitus(T2DM);more than half of T2DM patients suffer from OSAHS.Intermittent hypoxia(IH)plays an...BACKGROUND Obstructive sleep apnea(OSA)-hypopnea syndrome(OSAHS)has been recognized as a comorbidity of type 2 diabetes mellitus(T2DM);more than half of T2DM patients suffer from OSAHS.Intermittent hypoxia(IH)plays an important role in metabolic diseases,such as obesity and OSAHS,through various mechanisms,including altering the gut microecological composition and function.Therefore,it is important to study the role of gut microbiota in T2DM patients with OSAHS,which has a high incidence and is prone to several complications.AIM To assess whether IH is involved in altering the fecal microbiome in T2DM patients with OSAHS.METHODS Seventy-eight participants were enrolled from Henan Province People’s Hospital and divided into healthy control(HC,n=26),T2DM(n=25),and T2DM+OSA(n=27)groups based on their conditions.The fecal bacterial DNA of the research participants was extracted and subjected to 16S ribosomal RNA sequencing.The clinical indices,such as insulin resistance index,homocysteine(HCY)concentration,and the concentrations of inflammatory factors in the peripheral blood,were assessed and recorded.RESULTS Group T2DM+OSA had the highest apnea-hypopnea index(AHI)(2.3 vs 3.7 vs 13.7),oxygen desaturation index(0.65 vs 2.2 vs 9.1),HCY concentration(9.6μmol/L vs 10.3μmol/L vs 13.81μmol/L)and C-reactive protein(CRP)concentrations(0.3 mg/L vs 1.43 mg/L vs 2.11 mg/L),and lowest mean oxygen saturation(97.05%vs 96.6%vs 94.7%)among the three groups.Twelve and fifteen key differences in amplicon sequence variants were identified when comparing group T2DM+OSA with groups T2DM and HC,respectively.We found progressively decreased levels of Faecalibacterium,Eubacterium,and Lachnospiraceae,and an increase in the level of Actinomyces,which strongly correlated with the HCY,CRP,fasting plasma glucose,and hemoglobin A1c concentrations,AHI,mean oxygen saturation,and insulin resistance index in group T2DM+OSA(P<0.05).CONCLUSION For T2DM patients with OSAHS,IH may be involved in selective alterations of the gut microbiota,which may展开更多
In this review article,we explore the interplay between obstructive sleep apnea(OSA)and type 2 diabetes mellitus(T2DM),highlighting a significant yet often overlooked comorbidity.We delve into the pathophysiological l...In this review article,we explore the interplay between obstructive sleep apnea(OSA)and type 2 diabetes mellitus(T2DM),highlighting a significant yet often overlooked comorbidity.We delve into the pathophysiological links between OSA and diabetes,specifically how OSA exacerbates insulin resistance and disrupts glucose metabolism.The research examines the prevalence of OSA in diabetic patients and its role in worsening diabetes-related complications.Emphasizing the importance of comprehensive management,including weight control and positive airway pressure therapy,the study advocates integrated approaches to improve outcomes for patients with T2DM and OSA.This review underscores the necessity of recognizing and addressing OSA in diabetes care to ensure more effective treatment and better patient outcomes.展开更多
文摘目的探讨慢性阻塞性肺疾病合并2型糖尿病患者空腹血糖(FBG)、餐后2 h血糖(2 h PG)、白细胞介素-6(IL-6)、白细胞介素-8(IL-8)、肿瘤坏死因子-α(TNF-α)、干扰素-γ(IFN-γ)水平及与肺功能指标的相关性。方法选取2018年10月—2020年10月本院收治的慢性阻塞性肺疾病合并2型糖尿病62例为观察组,单纯慢性阻塞性肺疾病62例为对照组,另选取同期在本院行健康体检且身体健康者50例为健康对照组。对比3组FBG、2 h PG、IL-6、IL-8、TNF-α、IFN-γ、用力肺活量(FVC)、一秒用力呼气容积(FEV1)、第一秒用力呼气量占用力肺活量的比例(FEV1/FVC),分析慢性阻塞性肺疾病合并2型糖尿病患者FBG、2 h PG、IL-6、IL-8、TNF-α、IFN-γ与肺功能指标的相关性,并绘制受试者工作特征(ROC)曲线分析IL-6、TNF-α、FBG检测及三者联合检测对慢性阻塞性肺疾病患者发生2型糖尿病的预测价值。结果观察组FBG、2 h PG、IL-6、IL-8、TNF-α、IFN-γ水平均高于对照组及健康对照组(P<0.05),FVC、FEV1、FEV1/FVC水平均明显低于对照组及健康对照组(P<0.05)。慢性阻塞性肺疾病合并2型糖尿病患者FBG、2 h PG、IL-6、IL-8、TNF-α、IFN-γ水平与FVC、FEV1、FEV1/FVC呈负相关(P<0.05,P<0.01)。ROC曲线分析显示,IL-6、TNF-α、FBG检测及三者联合检测的曲线下面积分别为0.862、0.824、0.817和0.972,以联合检测曲线下面积最大。结论慢性阻塞性肺疾病合并2型糖尿病患者体内血糖相关指标及炎性因子水平升高,且与患者肺功能指标呈负相关;IL-6、TNF-α及FBG联合检测可作为预测慢性阻塞性肺疾病患者发生2型糖尿病的重要指标。
基金Supported by National Natural Science Foundation of China,No.81970705Central Plains Thousand Talents Plan,No.204200510026.
文摘BACKGROUND Obstructive sleep apnea(OSA)-hypopnea syndrome(OSAHS)has been recognized as a comorbidity of type 2 diabetes mellitus(T2DM);more than half of T2DM patients suffer from OSAHS.Intermittent hypoxia(IH)plays an important role in metabolic diseases,such as obesity and OSAHS,through various mechanisms,including altering the gut microecological composition and function.Therefore,it is important to study the role of gut microbiota in T2DM patients with OSAHS,which has a high incidence and is prone to several complications.AIM To assess whether IH is involved in altering the fecal microbiome in T2DM patients with OSAHS.METHODS Seventy-eight participants were enrolled from Henan Province People’s Hospital and divided into healthy control(HC,n=26),T2DM(n=25),and T2DM+OSA(n=27)groups based on their conditions.The fecal bacterial DNA of the research participants was extracted and subjected to 16S ribosomal RNA sequencing.The clinical indices,such as insulin resistance index,homocysteine(HCY)concentration,and the concentrations of inflammatory factors in the peripheral blood,were assessed and recorded.RESULTS Group T2DM+OSA had the highest apnea-hypopnea index(AHI)(2.3 vs 3.7 vs 13.7),oxygen desaturation index(0.65 vs 2.2 vs 9.1),HCY concentration(9.6μmol/L vs 10.3μmol/L vs 13.81μmol/L)and C-reactive protein(CRP)concentrations(0.3 mg/L vs 1.43 mg/L vs 2.11 mg/L),and lowest mean oxygen saturation(97.05%vs 96.6%vs 94.7%)among the three groups.Twelve and fifteen key differences in amplicon sequence variants were identified when comparing group T2DM+OSA with groups T2DM and HC,respectively.We found progressively decreased levels of Faecalibacterium,Eubacterium,and Lachnospiraceae,and an increase in the level of Actinomyces,which strongly correlated with the HCY,CRP,fasting plasma glucose,and hemoglobin A1c concentrations,AHI,mean oxygen saturation,and insulin resistance index in group T2DM+OSA(P<0.05).CONCLUSION For T2DM patients with OSAHS,IH may be involved in selective alterations of the gut microbiota,which may
文摘In this review article,we explore the interplay between obstructive sleep apnea(OSA)and type 2 diabetes mellitus(T2DM),highlighting a significant yet often overlooked comorbidity.We delve into the pathophysiological links between OSA and diabetes,specifically how OSA exacerbates insulin resistance and disrupts glucose metabolism.The research examines the prevalence of OSA in diabetic patients and its role in worsening diabetes-related complications.Emphasizing the importance of comprehensive management,including weight control and positive airway pressure therapy,the study advocates integrated approaches to improve outcomes for patients with T2DM and OSA.This review underscores the necessity of recognizing and addressing OSA in diabetes care to ensure more effective treatment and better patient outcomes.
