摘要
目的探讨老年慢性阻塞性肺疾病急性加重期(AECOPD)合并2型糖尿病患者血浆D-二聚体、C-反应蛋白(CRP)、空腹血糖(FBG)水平的动态变化特点。方法选取单纯AECOPD组(A组)65例和AECOPD合并2型糖尿病组(B组)65例,观察并比较2组入院后第1、3、7、14天D-二聚体、CRP、FBG水平的变化,分析D-二聚体、CRP、FBG的相关关系,Logistic回归分析D-二聚体水平升高的因素。结果 B组D-二聚体、CRP、FBG在入院后第1、3、7天均高于A组(P<0.01);D-二聚体、CRP值在A组自入院后第7天明显下降,在B组直到第14天明显下降;A组入院后各时间段FBG变化无明显差异,入院后B组FBG呈下降趋势;D-二聚体、CRP、FBG三者间均呈正相关(P<0.05);CRP、FBG、p(O2)、年龄是影响D-二聚体水平升高的因素。结论老年AECOPD合并2型糖尿病的患者在抗感染和控制血糖的同时,应注意动态监测D-二聚体水平,有助于改善AECOPD患者的临床及预后,降低病死率。
Objective To investigate dynamic changes of plasma D-dimer, C-reactive protein（CRP） and fasting plas-ma glucose（FBG） levels in elderly patients with acute exacerbation of chronic obstructive pulmonary disease（AECOPD）combined with type 2 diabetes mellitus. Methods AECOPD group（n=65） was used as A group, AECOPD combined withtype 2 diabetes mellitus group（n=65） was used as B group. Levels of D-dimer, CRP and FBG were observed and comparedbetween two groups in the first day, the 3rd day, the 7th day and the 14 th day after hospital admission. The correlation be-tween D-dimer, CRP and FBG was analyzed. Logistic regression analysis was used to estimate the factors affecting increasedplasma levels of D-dimer. Results Levels of D-dimer, CRP and FBG were significantly higher in B group than those of Agroup in the first day, the 3rd day, the 7th after hospital admission（P 0.01）. Values of D-dimer and CRP were declined ob-viously in A group in the 7th day after hospital admission, but in B group they were declined obviously until the 14 th day.There was no significant difference in FBG of A group. The level of FBG was significantly decreased in B group. There was apositive correlation between D-dimer, CRP and FBG（P 0.05）. Logistic regression analysis showed that CRP, FBG, p（O2）and age were the influence factors for the increased levels of D-dimer. Conclusion In elderly patients with AECOPD com-bined with type 2 diabetes mellitus, we should pay attention to anti-inflammatory and controlling blood sugar, and the dy-namic monitoring levels of D-dimer, which helps to improve the prognosis for patients with AECOPD, and reduce mortality.
出处
《天津医药》
CAS
2015年第7期784-787,共4页
Tianjin Medical Journal
