AIM:The prognosis of early gastric carcinoma (EGC) is generally excellent after surgery. The presence or absence of lymph node metastasis in EGC is an important prognostic factor. The survival and recurrence rates of ...AIM:The prognosis of early gastric carcinoma (EGC) is generally excellent after surgery. The presence or absence of lymph node metastasis in EGC is an important prognostic factor. The survival and recurrence rates of node-negative EGC are much better than those of node-positive EGC. This study examined the factors related to lymph node metastasis in EGC to determine the appropriate treatment for EGC.METHODS: We investigated 748 patients with EGC who underwent surgery between January 1985 and December 1999 at the Division of Gastroenterologic Surgery, Department of Surgery, Chonnam National University Hospital. Several clinicopathologic factors were investigated to analyze their relationship to lymph node metastasis: age, sex, tumor location, tumor size, gross type, histologic type, depth of invasion, extent of lymph node dissection, type of operation,and DNA ploidy.RESULTS:Lymph node metastases were found in 75 patients (10.0%). Univariate analysis showed that male sex, tumor size larger than 2.0cm, submucosal invasion of tumor, histologic differentiation, and DNA ploidy pattern were risk factors for regional lymph node metastasis in EGC patients. However, a multivariate analysis showed that three risk factors were associated with lymph node metastasis:large tumor size, undifferentiated histologic type and submucosal invasion. No statistical relationship was found for age, sex, tumor location, gross type, or DNA ploidy in multivariate analysis. The 5-year survival rate was 94.2% for those without lymph node metastasis and 87.3% for those with lymph node metastasis, and the difference was significant (P<0.05).CONCLUSION: In patients with EGC, the survival rate of patients with positive lymph nodes is significantly worse than that of patients with no lymph node metastasis. Therefore,a standard D2 lymphadenectomy should be performed in patients at high risk of lymph node metastasis: large tumor size, undifferentiated histologic type and submucosal invasion.展开更多
Over the past two decades, synchronization, as an interesting collective behavior of complex dynamical networks, has been attracting much attention. To reveal and analyze the inherent mechanism of synchronization in c...Over the past two decades, synchronization, as an interesting collective behavior of complex dynamical networks, has been attracting much attention. To reveal and analyze the inherent mechanism of synchronization in complex dynamical networks with time delays in nodes, this paper attempts to use PD and PI control protocols to achieve synchronization. Based on a classical network model, we investigate the PD and PI control for synchronization of complex dynamical networks with delayed nodes and obtain some sufficient conditions. By using Lyapunov functions and appropriate state transformations, we prove that global synchronization can be achieved via the above control protocols. Finally, some simulation examples are illustrated to validate the effectiveness of the proposed theoretical results.展开更多
文摘AIM:The prognosis of early gastric carcinoma (EGC) is generally excellent after surgery. The presence or absence of lymph node metastasis in EGC is an important prognostic factor. The survival and recurrence rates of node-negative EGC are much better than those of node-positive EGC. This study examined the factors related to lymph node metastasis in EGC to determine the appropriate treatment for EGC.METHODS: We investigated 748 patients with EGC who underwent surgery between January 1985 and December 1999 at the Division of Gastroenterologic Surgery, Department of Surgery, Chonnam National University Hospital. Several clinicopathologic factors were investigated to analyze their relationship to lymph node metastasis: age, sex, tumor location, tumor size, gross type, histologic type, depth of invasion, extent of lymph node dissection, type of operation,and DNA ploidy.RESULTS:Lymph node metastases were found in 75 patients (10.0%). Univariate analysis showed that male sex, tumor size larger than 2.0cm, submucosal invasion of tumor, histologic differentiation, and DNA ploidy pattern were risk factors for regional lymph node metastasis in EGC patients. However, a multivariate analysis showed that three risk factors were associated with lymph node metastasis:large tumor size, undifferentiated histologic type and submucosal invasion. No statistical relationship was found for age, sex, tumor location, gross type, or DNA ploidy in multivariate analysis. The 5-year survival rate was 94.2% for those without lymph node metastasis and 87.3% for those with lymph node metastasis, and the difference was significant (P<0.05).CONCLUSION: In patients with EGC, the survival rate of patients with positive lymph nodes is significantly worse than that of patients with no lymph node metastasis. Therefore,a standard D2 lymphadenectomy should be performed in patients at high risk of lymph node metastasis: large tumor size, undifferentiated histologic type and submucosal invasion.
基金Supported by the National Natural Science Foundation of China under Grant Nos.9060402960773150(国家自然科学基金)the National High-Teeh Research and Development Plan of China under Grant No.2077AA01Z219(国家高技术研究发展计划(863))
基金supported by the National Key Research and Development Program of China(Grant No.2016YFB0800401)the National Natural Science Foundation of China(Grant Nos.61621003,61532020,and61472027)the US Army Research Office(Grant No.W911NF-17-1-0535)
文摘Over the past two decades, synchronization, as an interesting collective behavior of complex dynamical networks, has been attracting much attention. To reveal and analyze the inherent mechanism of synchronization in complex dynamical networks with time delays in nodes, this paper attempts to use PD and PI control protocols to achieve synchronization. Based on a classical network model, we investigate the PD and PI control for synchronization of complex dynamical networks with delayed nodes and obtain some sufficient conditions. By using Lyapunov functions and appropriate state transformations, we prove that global synchronization can be achieved via the above control protocols. Finally, some simulation examples are illustrated to validate the effectiveness of the proposed theoretical results.
