We reported a biopsy proved case of minimal change nephrotic syndrome in a 72-year-old patient. The minimal change nephrotic syndrome has been steroid sensitive, but the patient had 7 relapses over a span of 5 years. ...We reported a biopsy proved case of minimal change nephrotic syndrome in a 72-year-old patient. The minimal change nephrotic syndrome has been steroid sensitive, but the patient had 7 relapses over a span of 5 years. Each time the dose of steroid is tapered, a relapse of the nephrotic syndrome occurred. Eventually, the patient was complaining of dysphagia and difficulty swallowing. Hospital work-up with barium swallow, endoscopy, and CT of the chest, abdomen and pelvis, revealed a focal stenotic lesion with mild to moderate esophageal dysmotility 7/15/2022. A diagnosis of an ulcerating lesion with biopsy confirmed a neuro-endocrine carcinoma of the gastro-esophageal junction was entertained. The CT of the chest/abdomen/pelvis, 7/19/2022, has shown, an esophageal mass of 5.1 × 5.6 × 7 cm of the gastro-esophageal junction with ulceration. No evidence of spread beyond the esophagus and stomach. The histology revealed a poorly differentiated neuroendocrine tumor of the gastro-esophageal junction. The patient underwent several rounds of chemotherapy, radiation, and surgery culminating in tumor control. His nephrotic syndrome was resolved after the tumor has been controlled by surgery and chemotherapy.展开更多
目的建立大鼠微小病变型肾病综合征模型,观察低分子右旋糖酐对肾病综合征水肿状态时肾小球基底膜足突形态的影响。方法采用连续式静脉输液法给药。标本用透射电镜观察,通过体视学方法比较正常组、模型组、盐水组(生理盐水+速尿)与右糖组...目的建立大鼠微小病变型肾病综合征模型,观察低分子右旋糖酐对肾病综合征水肿状态时肾小球基底膜足突形态的影响。方法采用连续式静脉输液法给药。标本用透射电镜观察,通过体视学方法比较正常组、模型组、盐水组(生理盐水+速尿)与右糖组(低分子右旋糖酐+速尿)肾小球基底膜足突形态的变化。结果正常组足突呈细长的指状突起,相邻足突之间的间隙及裂孔隔膜清楚可见;模型组足突广泛融合,足突间隙及裂孔隔膜消失;盐水组足突绝大部分处于融合状态,小部分虽未融合但仍处于明显肿胀的状态;右糖组足突肿胀明显减轻,表现为足突局段融合、局段肿胀与局段完全恢复正常混同存在的现象,多数足突间隙逐渐显现,有些甚至可清楚的看到裂孔隔膜。体视学形态计量结果表明,正常组与模型组,正常组与盐水组,右糖组与模型组,右糖组与盐水组这4对配组间体积密度、面密度及比表面均有显著差异或高度差异(P<0.05 or P<0.01);而右糖组与正常组、模型组与盐水组之间体积密度、面密度无差异(P>0.05),比表面有显著差异(P<0.05)。结论低分子右旋糖酐应用于水肿状态的肾病综合征,可以显著减轻足突肿胀并逐渐解除其融合状态。展开更多
文摘We reported a biopsy proved case of minimal change nephrotic syndrome in a 72-year-old patient. The minimal change nephrotic syndrome has been steroid sensitive, but the patient had 7 relapses over a span of 5 years. Each time the dose of steroid is tapered, a relapse of the nephrotic syndrome occurred. Eventually, the patient was complaining of dysphagia and difficulty swallowing. Hospital work-up with barium swallow, endoscopy, and CT of the chest, abdomen and pelvis, revealed a focal stenotic lesion with mild to moderate esophageal dysmotility 7/15/2022. A diagnosis of an ulcerating lesion with biopsy confirmed a neuro-endocrine carcinoma of the gastro-esophageal junction was entertained. The CT of the chest/abdomen/pelvis, 7/19/2022, has shown, an esophageal mass of 5.1 × 5.6 × 7 cm of the gastro-esophageal junction with ulceration. No evidence of spread beyond the esophagus and stomach. The histology revealed a poorly differentiated neuroendocrine tumor of the gastro-esophageal junction. The patient underwent several rounds of chemotherapy, radiation, and surgery culminating in tumor control. His nephrotic syndrome was resolved after the tumor has been controlled by surgery and chemotherapy.
文摘目的建立大鼠微小病变型肾病综合征模型,观察低分子右旋糖酐对肾病综合征水肿状态时肾小球基底膜足突形态的影响。方法采用连续式静脉输液法给药。标本用透射电镜观察,通过体视学方法比较正常组、模型组、盐水组(生理盐水+速尿)与右糖组(低分子右旋糖酐+速尿)肾小球基底膜足突形态的变化。结果正常组足突呈细长的指状突起,相邻足突之间的间隙及裂孔隔膜清楚可见;模型组足突广泛融合,足突间隙及裂孔隔膜消失;盐水组足突绝大部分处于融合状态,小部分虽未融合但仍处于明显肿胀的状态;右糖组足突肿胀明显减轻,表现为足突局段融合、局段肿胀与局段完全恢复正常混同存在的现象,多数足突间隙逐渐显现,有些甚至可清楚的看到裂孔隔膜。体视学形态计量结果表明,正常组与模型组,正常组与盐水组,右糖组与模型组,右糖组与盐水组这4对配组间体积密度、面密度及比表面均有显著差异或高度差异(P<0.05 or P<0.01);而右糖组与正常组、模型组与盐水组之间体积密度、面密度无差异(P>0.05),比表面有显著差异(P<0.05)。结论低分子右旋糖酐应用于水肿状态的肾病综合征,可以显著减轻足突肿胀并逐渐解除其融合状态。
