目的研究维生素E联合小剂量阿司匹林、钙剂、叶酸治疗对子痫前期的预防作用及对母胎结局的影响。方法前瞻性选取2018年1月至2022年1月合肥市第一人民医院收治的150例子痫前期高危孕妇,按照随机数字表法分为对照组和研究组,各75例。研究...目的研究维生素E联合小剂量阿司匹林、钙剂、叶酸治疗对子痫前期的预防作用及对母胎结局的影响。方法前瞻性选取2018年1月至2022年1月合肥市第一人民医院收治的150例子痫前期高危孕妇,按照随机数字表法分为对照组和研究组,各75例。研究组于对照组基础上联合给予维生素E处理,对照组行小剂量阿司匹林、钙剂、叶酸干预,持续至孕36周。比较两组孕妇的子痫前期发生率、治疗前后凝血四项[纤维蛋白原(Fib)、活化部分凝血活酶时间(APTT)、凝血酶时间(TT)、凝血酶原时间(PT)]、子宫动脉血流参数[阻力指数(RI)、收缩期峰值/舒张末期流速(S/D)、搏动指数(PI)]、母胎结局和新生儿出生指标。结果研究组孕妇子痫前期发生率为9.33%(7/75),明显低于对照组[22.67%(17/75)],差异有统计学意义(P<0.05)。两组孕妇治疗后Fib均明显低于治疗前,APTT、TT、PT均明显高于治疗前,且研究组Fib为(3.92±0.33)g/L,明显低于对照组[(4.15±0.35)g/L],APTT、TT、PT为(27.36±1.85)、(13.72±0.77)、(10.13±0.60)s,均明显高于对照组[(26.28±2.01)、(13.38±0.79)、(9.73±0.64)s],差异均有统计学意义(P<0.05)。两组孕妇治疗后子宫动脉RI、S/D、PI均明显低于治疗前,且研究组为0.37±0.06、1.73±0.45、0.62±0.17,明显低于对照组(0.42±0.08、1.91±0.48、0.70±0.19),差异均有统计学意义(P<0.05)。研究组胎儿生长受限、剖宫产、早产、胎盘早剥发生率为5.33%、13.33%、17.33%、6.67%,均明显低于对照组(16.00%、28.00%、34.67%、18.67%),差异有统计学意义(P<0.05)。研究组新生儿出生孕周、体重、1 min Apgar评分为(37.97±1.06)周、(2.94±0.91)kg、(9.53±0.74)分,均明显高于对照组[(37.22±1.01)周、(2.61±0.85)kg、(9.29±0.65)分],差异均有统计学意义(P<0.05)。结论维生素E联合小剂量阿司匹林、钙剂、叶酸能更有效改善子痫前期高危孕妇的凝血功能及子宫动脉血流动力学,在预防�展开更多
Objective: To evaluate the frequency of adverse maternal and perinatal outcomes in teenage pregnancies at secondary hospital Hyderabad. Methods: Retrospective record review was conducted between January 2012 to Januar...Objective: To evaluate the frequency of adverse maternal and perinatal outcomes in teenage pregnancies at secondary hospital Hyderabad. Methods: Retrospective record review was conducted between January 2012 to January 2016. Total No. of deliveries was 15,395 out of which No. of teenage was 452. Results: Rate of teenage pregnancy in our hospital during study period was 2.93%. Majority of women were uneducated. Teenage mother more likely to develop pregnancy induced hypertension 19.5%, frequency of mild, moderate, and severe anemia were reported to be 69.9%, 28.8% and 1.3% respectively. Conclusion: Fetal and neonatal outcome was not adversely affected. Teenage pregnancy outcome can be achieved favorable with good antenatal care.展开更多
文摘目的研究维生素E联合小剂量阿司匹林、钙剂、叶酸治疗对子痫前期的预防作用及对母胎结局的影响。方法前瞻性选取2018年1月至2022年1月合肥市第一人民医院收治的150例子痫前期高危孕妇,按照随机数字表法分为对照组和研究组,各75例。研究组于对照组基础上联合给予维生素E处理,对照组行小剂量阿司匹林、钙剂、叶酸干预,持续至孕36周。比较两组孕妇的子痫前期发生率、治疗前后凝血四项[纤维蛋白原(Fib)、活化部分凝血活酶时间(APTT)、凝血酶时间(TT)、凝血酶原时间(PT)]、子宫动脉血流参数[阻力指数(RI)、收缩期峰值/舒张末期流速(S/D)、搏动指数(PI)]、母胎结局和新生儿出生指标。结果研究组孕妇子痫前期发生率为9.33%(7/75),明显低于对照组[22.67%(17/75)],差异有统计学意义(P<0.05)。两组孕妇治疗后Fib均明显低于治疗前,APTT、TT、PT均明显高于治疗前,且研究组Fib为(3.92±0.33)g/L,明显低于对照组[(4.15±0.35)g/L],APTT、TT、PT为(27.36±1.85)、(13.72±0.77)、(10.13±0.60)s,均明显高于对照组[(26.28±2.01)、(13.38±0.79)、(9.73±0.64)s],差异均有统计学意义(P<0.05)。两组孕妇治疗后子宫动脉RI、S/D、PI均明显低于治疗前,且研究组为0.37±0.06、1.73±0.45、0.62±0.17,明显低于对照组(0.42±0.08、1.91±0.48、0.70±0.19),差异均有统计学意义(P<0.05)。研究组胎儿生长受限、剖宫产、早产、胎盘早剥发生率为5.33%、13.33%、17.33%、6.67%,均明显低于对照组(16.00%、28.00%、34.67%、18.67%),差异有统计学意义(P<0.05)。研究组新生儿出生孕周、体重、1 min Apgar评分为(37.97±1.06)周、(2.94±0.91)kg、(9.53±0.74)分,均明显高于对照组[(37.22±1.01)周、(2.61±0.85)kg、(9.29±0.65)分],差异均有统计学意义(P<0.05)。结论维生素E联合小剂量阿司匹林、钙剂、叶酸能更有效改善子痫前期高危孕妇的凝血功能及子宫动脉血流动力学,在预防�
文摘Objective: To evaluate the frequency of adverse maternal and perinatal outcomes in teenage pregnancies at secondary hospital Hyderabad. Methods: Retrospective record review was conducted between January 2012 to January 2016. Total No. of deliveries was 15,395 out of which No. of teenage was 452. Results: Rate of teenage pregnancy in our hospital during study period was 2.93%. Majority of women were uneducated. Teenage mother more likely to develop pregnancy induced hypertension 19.5%, frequency of mild, moderate, and severe anemia were reported to be 69.9%, 28.8% and 1.3% respectively. Conclusion: Fetal and neonatal outcome was not adversely affected. Teenage pregnancy outcome can be achieved favorable with good antenatal care.
