16 ADT carboxylate esters were prepared by means of esterification and these compounds were expected to increase the bioavailability of 4-hydroxyanehole trithione.In vivo studies showed that ADT concentration of 3a in...16 ADT carboxylate esters were prepared by means of esterification and these compounds were expected to increase the bioavailability of 4-hydroxyanehole trithione.In vivo studies showed that ADT concentration of 3a in plasma was much higher than that of ATT during 120 min.Compound 3a could reach blood peak values of ADT at 660.6 ng/mL which was about 14 times of that by ATT.Additionally,the acute toxicity assay indicated high safety of compound 3a that the maximum tolerated dose was no less than 3.25 g/kg.展开更多
[Objectives] To study the material foundation of liposoluble constituents from buds,flowers and fruits of Millettia speciosa Champ.and provide a reference for the development of flowers and fruits of Millettia specios...[Objectives] To study the material foundation of liposoluble constituents from buds,flowers and fruits of Millettia speciosa Champ.and provide a reference for the development of flowers and fruits of Millettia speciosa Champ.[Methods]The liposoluble constituents were extracted from buds,flowers and fruits of Millettia speciosa by Soxhlet extraction and solvent extraction method,and analyzed by GC-MS.[Results]24 compounds were identified from the liposoluble constituents of buds,accounting for 88. 31 % of the total liposoluble constituents,mainly comprising alkanes and olefins compounds( 52. 00%) and alcohols compounds( 17. 46%); 29 compounds were identified from the liposoluble constituents of flowers,accounting for 91. 38 % of the total liposoluble constituents,mainly comprising alkanes and olefins compounds( 60. 64%) and alcohols compounds( 17. 17%); 32 compounds were identified from the liposoluble constituents of fruits,accounting for 80. 01 % of the total liposoluble constituents,mainly comprising alkanes and olefins compounds( 32. 56%),phenyl and its derivatives compounds( 22. 46%) and fatty acids compounds( 12. 54%). 6 compounds were common in buds,flowers and fruits. [Conclusions] Although there were some differences in liposoluble constituents from flowers,fruits,leaves and roots of Millettia speciosa Champ.,the different parts of Millettia speciosa Champ. had development value.展开更多
[Objectives] To effectively develop Calotropis gigantea resources and find the biological active constituents with medicinal value.[Methods]The liposoluble constituents from C. gigantea roots were studied by GC-MS for...[Objectives] To effectively develop Calotropis gigantea resources and find the biological active constituents with medicinal value.[Methods]The liposoluble constituents from C. gigantea roots were studied by GC-MS for the first time. [Results] 62 constituents were separated and identified from C. gigantea roots,amounting to 60. 43% of the total constituents,α-amyrin( 4. 18%),ethyl palmitate( 3. 49%),1,7-dimethyl-naphthalene( 3. 06%) were the main liposoluble constituents. [Conclusions] Cardiac glycoside was mainly found in methanol extracts and not detected in liposoluble constituents by extraction of petroleum ether. However,the present study found another component of low toxicity—naphthalene and its derivatives.展开更多
[Objectives] To study the liposoluble constituents and their antimicrobial activity from the flowers of Calotropis gigantea.[Methods]The liposoluble constituents from the flowers of Calotropis gigantea were analyzed b...[Objectives] To study the liposoluble constituents and their antimicrobial activity from the flowers of Calotropis gigantea.[Methods]The liposoluble constituents from the flowers of Calotropis gigantea were analyzed by gas chromatography-mass spectrometry(GCMS) method and their relative content was determined by area normalization method; and their antimicrobial activity against 2 pathogens was tested by agar disc diffusion method. [Results]31 compounds were separated and identified,amounting to 85. 14% of the total constituents,27 compounds were reported for the first time in the study of the liposoluble constituents from Calotropis gigantea. The results indicated that the liposoluble constituents from the flowers of Calotropis gigantea exhibited weak antimicrobial activity against Staphylococcus aureus and Canidia albicans. [Conclusions] The research results provided scientific foundation for exploitation and utilization of Calotropis gigantea.展开更多
[Objectives]This paper aimed to analyze the liposoluble components in seeds of different bitter gourd germplasms.[Methods]Taking 3 bitter gourd germplasms from different sources as materials,the composition and relati...[Objectives]This paper aimed to analyze the liposoluble components in seeds of different bitter gourd germplasms.[Methods]Taking 3 bitter gourd germplasms from different sources as materials,the composition and relative contents of liposoluble components in the seeds were analyzed using gas chromatography-mass spectrometry(GC-MS).[Results]A total of 22,18 and 18 compounds were detected from Papua,Y7 and Y108,respectively,accounting for 38.63%,90.20%and 92.53%of the total liposoluble components.Among them,eight liposoluble components were unique to Papua,and two liposoluble components were unique to Y108.The composition and relative contents of liposoluble components differ among different bitter gourd germplasms.The main chemical components wereγ-tocopherol,vitamin E,andβ-tocopherol.The content ofγ-tocopherol was high in the three germplasms,accounting for 8.885%,20.090%and 20.314%,respectively.[Conclusions]This study can lay the foundation for breeding functional bitter gourd varieties.展开更多
Chlorogenic acid (CGA) is a natural antioxidant, and nowadays it has been used in medicine, food processing and cosmetic industry.However, to a certain extent its application is restricted because it is only soluble i...Chlorogenic acid (CGA) is a natural antioxidant, and nowadays it has been used in medicine, food processing and cosmetic industry.However, to a certain extent its application is restricted because it is only soluble in water but is lipo-insoluble.In this research, liposoluble chlorogenic laurate(CGL) was synthesized by acylation with lauroyl chloride (LC) in the presence of triethylamine (TEA) in non-water phase.It was found that the optimized synthesis conditions were as follows: with dimethylformamide (DMF) as the dissolution agent and thinner, n CGA∶n LC∶n TEA=1∶1∶1.5, temperature(35±1)℃ and reaction time 8 h.Under these conditions a light yellowish powder was obtained and the yield of CGL was 81.24 %.The structure of CGL was characterized by UV-Vis, IR, ESI-MS and 1H NMR. Theoretically, the method of quantum chemistry calculation was used to demonstrate the feasibility and rationality of molecular modification for CGA.Meanwhile, the result of the test of the use of CGL on Guangdong-type sausage showed that 0.05% of CGL could increase the antioxidant ability of the products.展开更多
文摘16 ADT carboxylate esters were prepared by means of esterification and these compounds were expected to increase the bioavailability of 4-hydroxyanehole trithione.In vivo studies showed that ADT concentration of 3a in plasma was much higher than that of ATT during 120 min.Compound 3a could reach blood peak values of ADT at 660.6 ng/mL which was about 14 times of that by ATT.Additionally,the acute toxicity assay indicated high safety of compound 3a that the maximum tolerated dose was no less than 3.25 g/kg.
基金Supported by Central Public-interest Scientific Institution Basal Research Fund for Chinese Academy of Tropical Agricultural Sciences(1630-032017051)Tropical Crop Germplasm Resources Protection Project of the Ministry of Agriculture(16RZZY-101)
文摘[Objectives] To study the material foundation of liposoluble constituents from buds,flowers and fruits of Millettia speciosa Champ.and provide a reference for the development of flowers and fruits of Millettia speciosa Champ.[Methods]The liposoluble constituents were extracted from buds,flowers and fruits of Millettia speciosa by Soxhlet extraction and solvent extraction method,and analyzed by GC-MS.[Results]24 compounds were identified from the liposoluble constituents of buds,accounting for 88. 31 % of the total liposoluble constituents,mainly comprising alkanes and olefins compounds( 52. 00%) and alcohols compounds( 17. 46%); 29 compounds were identified from the liposoluble constituents of flowers,accounting for 91. 38 % of the total liposoluble constituents,mainly comprising alkanes and olefins compounds( 60. 64%) and alcohols compounds( 17. 17%); 32 compounds were identified from the liposoluble constituents of fruits,accounting for 80. 01 % of the total liposoluble constituents,mainly comprising alkanes and olefins compounds( 32. 56%),phenyl and its derivatives compounds( 22. 46%) and fatty acids compounds( 12. 54%). 6 compounds were common in buds,flowers and fruits. [Conclusions] Although there were some differences in liposoluble constituents from flowers,fruits,leaves and roots of Millettia speciosa Champ.,the different parts of Millettia speciosa Champ. had development value.
基金Supported by National Natural Science Foundation of Hainan China(20168368)Species Resources(Tropical Crops)Conservation Project of the Ministry of Agriculture(151721301354052012)
文摘[Objectives] To effectively develop Calotropis gigantea resources and find the biological active constituents with medicinal value.[Methods]The liposoluble constituents from C. gigantea roots were studied by GC-MS for the first time. [Results] 62 constituents were separated and identified from C. gigantea roots,amounting to 60. 43% of the total constituents,α-amyrin( 4. 18%),ethyl palmitate( 3. 49%),1,7-dimethyl-naphthalene( 3. 06%) were the main liposoluble constituents. [Conclusions] Cardiac glycoside was mainly found in methanol extracts and not detected in liposoluble constituents by extraction of petroleum ether. However,the present study found another component of low toxicity—naphthalene and its derivatives.
基金Supported by National Natural Science Foundation of Hainan China(20168368)Agro-scientific Research in the Public Interest(201303117)
文摘[Objectives] To study the liposoluble constituents and their antimicrobial activity from the flowers of Calotropis gigantea.[Methods]The liposoluble constituents from the flowers of Calotropis gigantea were analyzed by gas chromatography-mass spectrometry(GCMS) method and their relative content was determined by area normalization method; and their antimicrobial activity against 2 pathogens was tested by agar disc diffusion method. [Results]31 compounds were separated and identified,amounting to 85. 14% of the total constituents,27 compounds were reported for the first time in the study of the liposoluble constituents from Calotropis gigantea. The results indicated that the liposoluble constituents from the flowers of Calotropis gigantea exhibited weak antimicrobial activity against Staphylococcus aureus and Canidia albicans. [Conclusions] The research results provided scientific foundation for exploitation and utilization of Calotropis gigantea.
基金Supported by National Natural Science Foundation of China(31601758)
文摘[Objectives]This paper aimed to analyze the liposoluble components in seeds of different bitter gourd germplasms.[Methods]Taking 3 bitter gourd germplasms from different sources as materials,the composition and relative contents of liposoluble components in the seeds were analyzed using gas chromatography-mass spectrometry(GC-MS).[Results]A total of 22,18 and 18 compounds were detected from Papua,Y7 and Y108,respectively,accounting for 38.63%,90.20%and 92.53%of the total liposoluble components.Among them,eight liposoluble components were unique to Papua,and two liposoluble components were unique to Y108.The composition and relative contents of liposoluble components differ among different bitter gourd germplasms.The main chemical components wereγ-tocopherol,vitamin E,andβ-tocopherol.The content ofγ-tocopherol was high in the three germplasms,accounting for 8.885%,20.090%and 20.314%,respectively.[Conclusions]This study can lay the foundation for breeding functional bitter gourd varieties.
文摘Chlorogenic acid (CGA) is a natural antioxidant, and nowadays it has been used in medicine, food processing and cosmetic industry.However, to a certain extent its application is restricted because it is only soluble in water but is lipo-insoluble.In this research, liposoluble chlorogenic laurate(CGL) was synthesized by acylation with lauroyl chloride (LC) in the presence of triethylamine (TEA) in non-water phase.It was found that the optimized synthesis conditions were as follows: with dimethylformamide (DMF) as the dissolution agent and thinner, n CGA∶n LC∶n TEA=1∶1∶1.5, temperature(35±1)℃ and reaction time 8 h.Under these conditions a light yellowish powder was obtained and the yield of CGL was 81.24 %.The structure of CGL was characterized by UV-Vis, IR, ESI-MS and 1H NMR. Theoretically, the method of quantum chemistry calculation was used to demonstrate the feasibility and rationality of molecular modification for CGA.Meanwhile, the result of the test of the use of CGL on Guangdong-type sausage showed that 0.05% of CGL could increase the antioxidant ability of the products.
