A Pd（II） catalyzed tandem reaction of o-alkynylbenzaldehydes or o-alkynylbenzaldimines with substituted indoles initiated by the intermolecular addition of indoles to the carbonyl or imine group followed by the nucl...A Pd（II） catalyzed tandem reaction of o-alkynylbenzaldehydes or o-alkynylbenzaldimines with substituted indoles initiated by the intermolecular addition of indoles to the carbonyl or imine group followed by the nucleopalladation of an intramolecular alkyne and quenching the carbon-palladium bond by protonolysis to regenerate the Pd（II） species was developed. The reaction can be carried out under mild conditions without the necessity of a redox system.展开更多
The biological activities of a series of 3,3-spirocyclic indole derivatives containing CF_(2), phosphine oxide,indole, and cyano functional groups were evaluated, and these derivatives were found to exhibit antiTMV, f...The biological activities of a series of 3,3-spirocyclic indole derivatives containing CF_(2), phosphine oxide,indole, and cyano functional groups were evaluated, and these derivatives were found to exhibit antiTMV, fungicidal, and insecticidal activities.展开更多
基金Project supported by the National Basic Research Program of China （No. 2009CB825300） and the Natural Science Foundation of China （Nos. 20732005, 20872158）.
文摘A Pd（II） catalyzed tandem reaction of o-alkynylbenzaldehydes or o-alkynylbenzaldimines with substituted indoles initiated by the intermolecular addition of indoles to the carbonyl or imine group followed by the nucleopalladation of an intramolecular alkyne and quenching the carbon-palladium bond by protonolysis to regenerate the Pd（II） species was developed. The reaction can be carried out under mild conditions without the necessity of a redox system.
基金National Natural Science Foundation of China (Nos.21732002,22077071,21977056)Frontiers Science Center for New Organic Matter,Nankai University (No.63181206)the Fundamental Research Funds for the Central Universities,Nankai University (No.63201043)。
文摘The biological activities of a series of 3,3-spirocyclic indole derivatives containing CF_(2), phosphine oxide,indole, and cyano functional groups were evaluated, and these derivatives were found to exhibit antiTMV, fungicidal, and insecticidal activities.
