Nonalcoholic fatty liver disease(NAFLD), which is characterized by excessive fat accumulation in the liver of patients who consume little or no alcohol, becomes increasingly common with rapid economic development. Lon...Nonalcoholic fatty liver disease(NAFLD), which is characterized by excessive fat accumulation in the liver of patients who consume little or no alcohol, becomes increasingly common with rapid economic development. Long-term excess fat accumulation leads to NAFLD and represents a global health problem with no effective therapeutic approach. NAFLD is considered to be a series of complex, multifaceted pathological processes involving oxidative stress, inflammation, apoptosis, and metabolism. Over the past decades, herbal medicines have garnered growing attention as potential therapeutic agents to prevent and treat NAFLD, due to their high efficacy and low risk of side effects. In this review, we evaluate the use of herbal medicines(including traditional Chinese herbal formulas, crude extracts from medicinal plants, and pure natural products) to treat NAFLD. These herbal medicines are natural resources that can inform innovative drug research and the development of treatments for NAFLD in the future.展开更多
Within the public health sector of Hong Kong(China),there is a consensus around the important role of traditional Chinese medicines.For Hong Kong(China)to play a bridging role to bring Chinese medicines to the global ...Within the public health sector of Hong Kong(China),there is a consensus around the important role of traditional Chinese medicines.For Hong Kong(China)to play a bridging role to bring Chinese medicines to the global market requires a concerted effort from the government,academic institutes and industries.The release of the final version of the European Medicines Agencies guidance document,which details the acceptance of minimum requirements to nonclinical package in bibliographical applications,grants the opportunity for well-established and traditional herbal medicines to demonstrate an‘acceptable safe’status for registration in the European Union.It is anticipated that this minimum nonclinical package can be applied to demonstrate the safe use of many traditional Chinese medicines regardless of their eligibility to be registered under the simplified procedure within the European Union.This paper conceptualizes an integration of a simplified evaluation route for eligible proprietary Chinese medicines(pCm)with long history of use into the existing drug regulatory framework in Hong Kong(China).Such integration utilizing the minimum nonclinical package,based on bibliographical data or expert report,as proof of evidence to demonstrate safety for pCm with long history of use requires less demand in scientific resources.With Hong Kong(China)conducting‘first hand’review for eligible pCm,it provides an option for overseas and local pharmaceutical companies to register their products in Hong Kong(China)without the need to rely on issuance of Certificate of Pharmaceutical Product from other countries.This could bring eligible pCm with long history of use to reach international risk-based standard and to be marketed globally as‘medicines’to reach their full therapeutic potential.An important process to positioning Hong Kong(China)to compete with other countries in promoting importation and exportation of pCm to better serve the global health.展开更多
Objective] This study was conducted to evaluate the product quality and safety of Peristrophe roxburghiana_ col ected from different places in Hechi City, northwest of Gunagxi, so as to provide basic data for further ...Objective] This study was conducted to evaluate the product quality and safety of Peristrophe roxburghiana_ col ected from different places in Hechi City, northwest of Gunagxi, so as to provide basic data for further development and uti-lization of the characteristic plant resource P. roxburghiana. [Method] Contents of 9 kinds of heavy metals including Cd, Mn, Pb, Zn and Cu in the herb were deter-mined by the method of wet digestion-flame atomic absorption spectrophotometry and atomic fluorescence spectrometry, respectively. [Results] Heavy metal contents of Cd, Mn, Pb, Fe, Cu, Zn, As, Hg and Se were 1.62-17.25, 8.93-142.53, 4.37-18.43, 103.7-242.81, 2.55-5.35, 85.40-146.30, 0.07-0.54, 0.00-0.08 and 0.00-0.47 mg/kg, respectively. According to the national food safety standards and Green Trade Standards of lmporting ＆amp; Exporting Medicinal plants ＆amp; Preparations, the heavy metal contents of the P. roxburghiana_samples col ected from different coun-ties in Hechi City exceeded standards or at the critical values. Among which, Cd, Pb and Zn contents of the samples are seriously higher than the standards. [Con-clusion] Therefore, the impact of soil heavy metal pol ution on the safety of edible plants in the northwest of Guangxi should be highly concerned.展开更多
Objective： To prevent the deterioration of osteopenia, a triple herb product Bo-gu Ling （补骨灵, ELP） was created for a clinical trial on post-menopausal women suffering from osteopenia. Methods： The design of the...Objective： To prevent the deterioration of osteopenia, a triple herb product Bo-gu Ling （补骨灵, ELP） was created for a clinical trial on post-menopausal women suffering from osteopenia. Methods： The design of the clinical trial was of randomized, double-blind, placebo-controlled nature. A total of 150 women aged 40-60 years, who were after menopause for at least 1 year and their lumbar spine bone mineral density （BMD） must be lower than 0.891 g/cm2, were recruited and randomly divided into the ELP group treated with ELP and the placebo group, with 75 in each group. The primary endpoint was the BMD of the lumbar spine that was assessed at baseline, 6 and 12 months after treatment. Secondary endpoints included peripheral quantitative computed tomography （pQCT） measurements of distal tibia and the changes in the quality of life （QOL）. Results： The spine BMD of the ELP group was increased by 0.69% in the subjects who were more than 10 years after menopause. In contrast, the placebo group of the same stratum decreased by 0.61% （P=0.067）. In the subjects with more than 10 years duration of menopause, the hip BMD increased by 0.21% in the ELP group, compared with a decrease of 0.52% in the placebo group （P=0.159）. The tibia strengthstrain index was increased by 1.94% in the ELP group compared with 0.33% in the placebo group （P=0.047）. Physical function of SF-36 QOL questionnaire was remarkably improved compared with the baseline, but did not show dominance over the placebo group. Conclusion： ELP showed potential benefit in improving BMD on the women who experienced over 10 years of menopause.展开更多
Diabetes mellitus(DM)is characterized by persistently elevated blood glucose concentration that lead to multisystem complications.There are about 400 medicinal plants cited to have a beneficial effect on DM.We must ch...Diabetes mellitus(DM)is characterized by persistently elevated blood glucose concentration that lead to multisystem complications.There are about 400 medicinal plants cited to have a beneficial effect on DM.We must choose products wisely based on data derived from scientific studies.However,a major obstacle in the amalgamation of herbal medicine in modern medical practices is the lack of clinical data on its safety,efficacy and drug interaction.Trials of these herbal products often underreport the side effects and other crucial intervention steps deviating from the standards set by Consolidated Standards of Reporting Trials.Due to a lack of knowledge of the active compounds present in most herbal medicines,product standardization is difficult.Cost-effectiveness is another issue that needs to be kept in mind.In this mini-review,we focus on the antihyperglycemic effect of herbal products that are commonly used,along with the concerns stated above.展开更多
Pulmonary fibrosis(PF)is a chronic,progressive,and irreversible pulmonary interstitial disease with unclear pathogenesis.Currently,there are few treatment options for managing PF.Inhalation therapy,as a routine treatm...Pulmonary fibrosis(PF)is a chronic,progressive,and irreversible pulmonary interstitial disease with unclear pathogenesis.Currently,there are few treatment options for managing PF.Inhalation therapy,as a routine treatment for respiratory diseases,is being used to study the treatment of PF.Some herbal medicines and their active ingredients have been reported to have anti-PF effects.This review aims to provide an overview of the latest developments in inhalation therapy,focusing on the utilization of chemical medicines and herbal medicines for the treatment of PF in both clinical practice and basic research.The inhalation of chemical drugs such as pirfenidone,nintedanib,N-acetylcysteine,and interferon-γhas been shown to demonstrate anti-PF effects.Additionally,the inhalation of various natural products derived from herbal medicines,encompassing polyphenols,alkaloids,flavonoids,saponins,terpenoids,and herbal extracts,contributes to the therapeutic management of PF through diverse mechanisms.The inhalation of both chemical and herbal medicines presents promising advantages in the treatment of PF.Further clinical trials are required to investigate the effectiveness,safety,and mechanism of action of inhalation therapy utilizing natural products derived from herbal medicines.展开更多
Objective:To assess the anti-tumor effects of Pistacia atlantica methanolic extract(PAME)compared with cyclophosphamide against Ehrlich solid tumors in mice.Methods:Swiss albino mice(n=40)were divided into five groups...Objective:To assess the anti-tumor effects of Pistacia atlantica methanolic extract(PAME)compared with cyclophosphamide against Ehrlich solid tumors in mice.Methods:Swiss albino mice(n=40)were divided into five groups:normal control mice,mice with Ehrlich solid tumors treated with normal saline,mice with Ehrlich solid tumors treated with cyclophosphamide intraperitoneally once a day for 14 d,or 50mg/kg or 100 mg/kg PAME orally once a day for 14 d.Tumor growth inhibition,body weight,tumor markers,liver and kidney enzymes,oxidative stress markers,antioxidant enzymes,tumor necrosis factor-alpha level(TNF-α),and apoptosis-regulatory gene expression were evaluated.Results:Treatment of mice bearing Ehrlich solid tumors with PAME at 50 and 100 mg/kg orally significantly decreased tumor volume,body weight,tumor markers,liver and kidney enzymes,oxidative stress markers and TNF-αlevel in comparison with mice with Ehrlich solid tumors receiving normal saline.whereas PAME at 50 and 100 mg/kg/day significantly elevated the level of antioxidant enzymes(P<0.05).Conclusions:Pistacia atlantica methanolic extract has potent antitumor activity in mice.Therefore,the extract might be considered as an alternative anticancer agent against tumors,however,additional studies especially in the clinical setting are required to confirm this finding.展开更多
Objective:Insecticidal activity of Clerodendrum capitatum extracts against the stored product insect pest,Sitophilus oryzae(L.),Rhyzopertha dominica(F.),and Tribolium castaneum(Herbst)were investigated.Materials and M...Objective:Insecticidal activity of Clerodendrum capitatum extracts against the stored product insect pest,Sitophilus oryzae(L.),Rhyzopertha dominica(F.),and Tribolium castaneum(Herbst)were investigated.Materials and Methods:Hundred grams of C.capitatum powder was sequentially extracted with a series of solvents of increasing polarity in a Soxhlet apparatus and the extracts were concentrated on rotary evaporator to make it solvent free and the residue dissolved in a known volume of methanol and the solution was assayed for insecticidal activity by the fumigant toxicity.Hexane extract which showed maximum activity was selected for the preparation of herbal formulation and for its insecticidal properties and phytotoxicity.The herbal formulation obtained from leaves of C.capitatum was investigated by GCMS and GC/FID.Results:Clerodendrum capitatum ethyl extract had a very strong repellent activity to adults of all three major stored grain insects and was significantly repellent at a 1.58 mg/cm^(2).The hexane extract(oil)had high fumigant activity with LC_(50) values in the range between 25 and 32μg/L.A total of 14 components representing 97.8%of the formulation were identified and the main compounds in the formulation were found to be 2-Heptanone,3-methyl(33.9%)and Hexahydrofarnesyl acetone(25.3%)followed by 3-Dodecen-1-al(10.2%)and 8-Methyl-1-undecene(4.9%).Further,herbal formulation was found to be highly toxic to mixed age cultures of all three major stored grain insect pests which recorded 80%-90%mortality at dose of 200μg/L in 24 h exposure,where as 100%mortality achieved at dose of 200μg/L in 72 h exposure,respectively.Conclusion:The results indicate that extracts and formulation of C.capitatum has the potential to be developed in to a natural insecticide or repellent for controlling of stored product beetles.展开更多
基金Supported by Doctorate in Higher Education Institutions of Ministry of Education,No.20122105110004
文摘Nonalcoholic fatty liver disease(NAFLD), which is characterized by excessive fat accumulation in the liver of patients who consume little or no alcohol, becomes increasingly common with rapid economic development. Long-term excess fat accumulation leads to NAFLD and represents a global health problem with no effective therapeutic approach. NAFLD is considered to be a series of complex, multifaceted pathological processes involving oxidative stress, inflammation, apoptosis, and metabolism. Over the past decades, herbal medicines have garnered growing attention as potential therapeutic agents to prevent and treat NAFLD, due to their high efficacy and low risk of side effects. In this review, we evaluate the use of herbal medicines(including traditional Chinese herbal formulas, crude extracts from medicinal plants, and pure natural products) to treat NAFLD. These herbal medicines are natural resources that can inform innovative drug research and the development of treatments for NAFLD in the future.
文摘Within the public health sector of Hong Kong(China),there is a consensus around the important role of traditional Chinese medicines.For Hong Kong(China)to play a bridging role to bring Chinese medicines to the global market requires a concerted effort from the government,academic institutes and industries.The release of the final version of the European Medicines Agencies guidance document,which details the acceptance of minimum requirements to nonclinical package in bibliographical applications,grants the opportunity for well-established and traditional herbal medicines to demonstrate an‘acceptable safe’status for registration in the European Union.It is anticipated that this minimum nonclinical package can be applied to demonstrate the safe use of many traditional Chinese medicines regardless of their eligibility to be registered under the simplified procedure within the European Union.This paper conceptualizes an integration of a simplified evaluation route for eligible proprietary Chinese medicines(pCm)with long history of use into the existing drug regulatory framework in Hong Kong(China).Such integration utilizing the minimum nonclinical package,based on bibliographical data or expert report,as proof of evidence to demonstrate safety for pCm with long history of use requires less demand in scientific resources.With Hong Kong(China)conducting‘first hand’review for eligible pCm,it provides an option for overseas and local pharmaceutical companies to register their products in Hong Kong(China)without the need to rely on issuance of Certificate of Pharmaceutical Product from other countries.This could bring eligible pCm with long history of use to reach international risk-based standard and to be marketed globally as‘medicines’to reach their full therapeutic potential.An important process to positioning Hong Kong(China)to compete with other countries in promoting importation and exportation of pCm to better serve the global health.
基金Supported by Fund for Key Laboratories in Guangxi Universities-Featured Resource Research and Development Laboratory of Northwest of Guangxi(GJKY 2010[6])Fund for Platform Built by University and Local Government or University and EnterpriseLocal Resource Protection and Utilization Engineering Center of Northwest of Guangxi(GJKY 2010[9])~~
文摘Objective] This study was conducted to evaluate the product quality and safety of Peristrophe roxburghiana_ col ected from different places in Hechi City, northwest of Gunagxi, so as to provide basic data for further development and uti-lization of the characteristic plant resource P. roxburghiana. [Method] Contents of 9 kinds of heavy metals including Cd, Mn, Pb, Zn and Cu in the herb were deter-mined by the method of wet digestion-flame atomic absorption spectrophotometry and atomic fluorescence spectrometry, respectively. [Results] Heavy metal contents of Cd, Mn, Pb, Fe, Cu, Zn, As, Hg and Se were 1.62-17.25, 8.93-142.53, 4.37-18.43, 103.7-242.81, 2.55-5.35, 85.40-146.30, 0.07-0.54, 0.00-0.08 and 0.00-0.47 mg/kg, respectively. According to the national food safety standards and Green Trade Standards of lmporting ＆amp; Exporting Medicinal plants ＆amp; Preparations, the heavy metal contents of the P. roxburghiana_samples col ected from different coun-ties in Hechi City exceeded standards or at the critical values. Among which, Cd, Pb and Zn contents of the samples are seriously higher than the standards. [Con-clusion] Therefore, the impact of soil heavy metal pol ution on the safety of edible plants in the northwest of Guangxi should be highly concerned.
文摘Objective： To prevent the deterioration of osteopenia, a triple herb product Bo-gu Ling （补骨灵, ELP） was created for a clinical trial on post-menopausal women suffering from osteopenia. Methods： The design of the clinical trial was of randomized, double-blind, placebo-controlled nature. A total of 150 women aged 40-60 years, who were after menopause for at least 1 year and their lumbar spine bone mineral density （BMD） must be lower than 0.891 g/cm2, were recruited and randomly divided into the ELP group treated with ELP and the placebo group, with 75 in each group. The primary endpoint was the BMD of the lumbar spine that was assessed at baseline, 6 and 12 months after treatment. Secondary endpoints included peripheral quantitative computed tomography （pQCT） measurements of distal tibia and the changes in the quality of life （QOL）. Results： The spine BMD of the ELP group was increased by 0.69% in the subjects who were more than 10 years after menopause. In contrast, the placebo group of the same stratum decreased by 0.61% （P=0.067）. In the subjects with more than 10 years duration of menopause, the hip BMD increased by 0.21% in the ELP group, compared with a decrease of 0.52% in the placebo group （P=0.159）. The tibia strengthstrain index was increased by 1.94% in the ELP group compared with 0.33% in the placebo group （P=0.047）. Physical function of SF-36 QOL questionnaire was remarkably improved compared with the baseline, but did not show dominance over the placebo group. Conclusion： ELP showed potential benefit in improving BMD on the women who experienced over 10 years of menopause.
文摘Diabetes mellitus(DM)is characterized by persistently elevated blood glucose concentration that lead to multisystem complications.There are about 400 medicinal plants cited to have a beneficial effect on DM.We must choose products wisely based on data derived from scientific studies.However,a major obstacle in the amalgamation of herbal medicine in modern medical practices is the lack of clinical data on its safety,efficacy and drug interaction.Trials of these herbal products often underreport the side effects and other crucial intervention steps deviating from the standards set by Consolidated Standards of Reporting Trials.Due to a lack of knowledge of the active compounds present in most herbal medicines,product standardization is difficult.Cost-effectiveness is another issue that needs to be kept in mind.In this mini-review,we focus on the antihyperglycemic effect of herbal products that are commonly used,along with the concerns stated above.
基金supported by the National Natural Science Foundation of China under Grant[No.82004141]Guangdong Basic and Applied Basic Research Foundation[No.2023A1515011243]+2 种基金Bao'an Traditional Chinese Medicine Development Foundation under Grant[No.2020KJCX-KTYJ-5,2022KJCX-ZJZL-11]Science,Technology,and Innovation Commission of Shenzhen Municipality under Grant[No.JCYJ20190808160407500]Shenzhen Bao’an Traditional Chinese Medicine Hospital Research Program under Grant[No.BAZYY20220701].
文摘Pulmonary fibrosis(PF)is a chronic,progressive,and irreversible pulmonary interstitial disease with unclear pathogenesis.Currently,there are few treatment options for managing PF.Inhalation therapy,as a routine treatment for respiratory diseases,is being used to study the treatment of PF.Some herbal medicines and their active ingredients have been reported to have anti-PF effects.This review aims to provide an overview of the latest developments in inhalation therapy,focusing on the utilization of chemical medicines and herbal medicines for the treatment of PF in both clinical practice and basic research.The inhalation of chemical drugs such as pirfenidone,nintedanib,N-acetylcysteine,and interferon-γhas been shown to demonstrate anti-PF effects.Additionally,the inhalation of various natural products derived from herbal medicines,encompassing polyphenols,alkaloids,flavonoids,saponins,terpenoids,and herbal extracts,contributes to the therapeutic management of PF through diverse mechanisms.The inhalation of both chemical and herbal medicines presents promising advantages in the treatment of PF.Further clinical trials are required to investigate the effectiveness,safety,and mechanism of action of inhalation therapy utilizing natural products derived from herbal medicines.
文摘Objective:To assess the anti-tumor effects of Pistacia atlantica methanolic extract(PAME)compared with cyclophosphamide against Ehrlich solid tumors in mice.Methods:Swiss albino mice(n=40)were divided into five groups:normal control mice,mice with Ehrlich solid tumors treated with normal saline,mice with Ehrlich solid tumors treated with cyclophosphamide intraperitoneally once a day for 14 d,or 50mg/kg or 100 mg/kg PAME orally once a day for 14 d.Tumor growth inhibition,body weight,tumor markers,liver and kidney enzymes,oxidative stress markers,antioxidant enzymes,tumor necrosis factor-alpha level(TNF-α),and apoptosis-regulatory gene expression were evaluated.Results:Treatment of mice bearing Ehrlich solid tumors with PAME at 50 and 100 mg/kg orally significantly decreased tumor volume,body weight,tumor markers,liver and kidney enzymes,oxidative stress markers and TNF-αlevel in comparison with mice with Ehrlich solid tumors receiving normal saline.whereas PAME at 50 and 100 mg/kg/day significantly elevated the level of antioxidant enzymes(P<0.05).Conclusions:Pistacia atlantica methanolic extract has potent antitumor activity in mice.Therefore,the extract might be considered as an alternative anticancer agent against tumors,however,additional studies especially in the clinical setting are required to confirm this finding.
文摘Objective:Insecticidal activity of Clerodendrum capitatum extracts against the stored product insect pest,Sitophilus oryzae(L.),Rhyzopertha dominica(F.),and Tribolium castaneum(Herbst)were investigated.Materials and Methods:Hundred grams of C.capitatum powder was sequentially extracted with a series of solvents of increasing polarity in a Soxhlet apparatus and the extracts were concentrated on rotary evaporator to make it solvent free and the residue dissolved in a known volume of methanol and the solution was assayed for insecticidal activity by the fumigant toxicity.Hexane extract which showed maximum activity was selected for the preparation of herbal formulation and for its insecticidal properties and phytotoxicity.The herbal formulation obtained from leaves of C.capitatum was investigated by GCMS and GC/FID.Results:Clerodendrum capitatum ethyl extract had a very strong repellent activity to adults of all three major stored grain insects and was significantly repellent at a 1.58 mg/cm^(2).The hexane extract(oil)had high fumigant activity with LC_(50) values in the range between 25 and 32μg/L.A total of 14 components representing 97.8%of the formulation were identified and the main compounds in the formulation were found to be 2-Heptanone,3-methyl(33.9%)and Hexahydrofarnesyl acetone(25.3%)followed by 3-Dodecen-1-al(10.2%)and 8-Methyl-1-undecene(4.9%).Further,herbal formulation was found to be highly toxic to mixed age cultures of all three major stored grain insect pests which recorded 80%-90%mortality at dose of 200μg/L in 24 h exposure,where as 100%mortality achieved at dose of 200μg/L in 72 h exposure,respectively.Conclusion:The results indicate that extracts and formulation of C.capitatum has the potential to be developed in to a natural insecticide or repellent for controlling of stored product beetles.
