[Objectives]To develop a paeonol bead popping gum with hypoglycemic effect.[Methods]The paeonol bead popping gum was prepared by the"two-step method",that is,the pill core was prepared by the guttate pill me...[Objectives]To develop a paeonol bead popping gum with hypoglycemic effect.[Methods]The paeonol bead popping gum was prepared by the"two-step method",that is,the pill core was prepared by the guttate pill method,and then the coating was cured by sodium alginate solution and CaCl_(2) solution.The single factor method was used to determine the effects of PEG-4000:paeonol dosage ratio,dropper diameter,condensation time,dropping distance,melting temperature on the comprehensive score of paeonol guttate pill,and the effects of sodium alginate solution concentration,CaCl_(2) solution concentration,number of coating layers,drying time on the comprehensive score of popping gum.Finally,the optimal process was determined and verified by orthogonal experiment method.[Results]When the dosage ratio of PEG-4000:paeonol was 4∶1,the dropper diameter was 4 mm,the condensation time was 5 min,the dropping distance was 6 cm,and the melting temperature was 90℃,the quality of the prepared guttate pill was the optimal.When the concentration of sodium alginate solution was 0.02 g/mL,the concentration of CaCl_(2) solution was 0.25 g/mL,the number of coating layers was 3,and the drying time was 25 min,the appearance and comprehensive score of the obtained popping beads were the optimal.[Conclusions]This study is expected to provide some reference and basis for the development and utilization of hypoglycemic products of traditional Chinese medicine.展开更多
基金Supported by National Natural Science Foundation of China(81560659&81860771)Science and Technology Project of the Education Department of Jiangxi Province(GJJ201219)+1 种基金Students’Innovative Entrepreneurial Training Plan Program of Jiangxi University of Traditional Chinese Medicine(S202110412003,202010412025,202110412028)Doctoral Research Startup Fund of Jiangxi University of Traditional Chinese Medicine(2018WBZR011)。
文摘[Objectives]To develop a paeonol bead popping gum with hypoglycemic effect.[Methods]The paeonol bead popping gum was prepared by the"two-step method",that is,the pill core was prepared by the guttate pill method,and then the coating was cured by sodium alginate solution and CaCl_(2) solution.The single factor method was used to determine the effects of PEG-4000:paeonol dosage ratio,dropper diameter,condensation time,dropping distance,melting temperature on the comprehensive score of paeonol guttate pill,and the effects of sodium alginate solution concentration,CaCl_(2) solution concentration,number of coating layers,drying time on the comprehensive score of popping gum.Finally,the optimal process was determined and verified by orthogonal experiment method.[Results]When the dosage ratio of PEG-4000:paeonol was 4∶1,the dropper diameter was 4 mm,the condensation time was 5 min,the dropping distance was 6 cm,and the melting temperature was 90℃,the quality of the prepared guttate pill was the optimal.When the concentration of sodium alginate solution was 0.02 g/mL,the concentration of CaCl_(2) solution was 0.25 g/mL,the number of coating layers was 3,and the drying time was 25 min,the appearance and comprehensive score of the obtained popping beads were the optimal.[Conclusions]This study is expected to provide some reference and basis for the development and utilization of hypoglycemic products of traditional Chinese medicine.
