Peripheral nerve injuries commonly occur due to trauma,like a traffic accident.Peripheral nerves get severed,causing motor neuron death and potential muscle atrophy.The current golden standard to treat peripheral nerv...Peripheral nerve injuries commonly occur due to trauma,like a traffic accident.Peripheral nerves get severed,causing motor neuron death and potential muscle atrophy.The current golden standard to treat peripheral nerve lesions,especially lesions with large(≥3 cm)nerve gaps,is the use of a nerve autograft or reimplantation in cases where nerve root avulsions occur.If not tended early,degeneration of motor neurons and loss of axon regeneration can occur,leading to loss of function.Although surgical procedures exist,patients often do not fully recover,and quality of life deteriorates.Peripheral nerves have limited regeneration,and it is usually mediated by Schwann cells and neurotrophic factors,like glial cell line-derived neurotrophic factor,as seen in Wallerian degeneration.Glial cell line-derived neurotrophic factor is a neurotrophic factor known to promote motor neuron survival and neurite outgrowth.Glial cell line-derived neurotrophic factor is upregulated in different forms of nerve injuries like axotomy,sciatic nerve crush,and compression,thus creating great interest to explore this protein as a potential treatment for peripheral nerve injuries.Exogenous glial cell line-derived neurotrophic factor has shown positive effects in regeneration and functional recovery when applied in experimental models of peripheral nerve injuries.In this review,we discuss the mechanism of repair provided by Schwann cells and upregulation of glial cell line-derived neurotrophic factor,the latest findings on the effects of glial cell line-derived neurotrophic factor in different types of peripheral nerve injuries,delivery systems,and complementary treatments(electrical muscle stimulation and exercise).Understanding and overcoming the challenges of proper timing and glial cell line-derived neurotrophic factor delivery is paramount to creating novel treatments to tend to peripheral nerve injuries to improve patients'quality of life.展开更多
One of the crucial and challenging issues for researchers is presenting an appropriate approach to evaluate the aerodynamic characteristics of air cushion vehicles(ACVs)in terms of system design parameters.One of thes...One of the crucial and challenging issues for researchers is presenting an appropriate approach to evaluate the aerodynamic characteristics of air cushion vehicles(ACVs)in terms of system design parameters.One of these issues includes introducing a suitable approach to analyze the effect of geometric shapes on the aerodynamic characteristics of ACVs.The main novelty of this paper lies in presenting an innovative method to study the geometric shape effect on air cushion lift force,which has not been investigated thus far.Moreover,this paper introduces a new approximate mathematical formula for calculating the air cushion lift force in terms of parameters,including the air gap,lateral gaps,air inlet velocity,and scaling factor for the first time.Thus,we calculate the aerodynamic lift force applied to nine different shapes of the air cushions used in the ACVs in the present paper through the ANSYS Fluent software.The geometrical shapes studied in this paper are rectangular,square,equilateral triangle,circular,elliptic shapes,and four other combined shapes,including circle-rectangle,circle-square,hexagonal,and fillet square.Results showed that the cushion with a circular pattern produces the highest lift force among other geometric shapes with the same conditions.The increase in the cushion lift force can be attributed to the fillet with a square shape and its increasing radius compared with the square shape.展开更多
基金funded by the NIH Grant 1R15AG022908-01A2 and the Western Michigan University(to JMS)。
文摘Peripheral nerve injuries commonly occur due to trauma,like a traffic accident.Peripheral nerves get severed,causing motor neuron death and potential muscle atrophy.The current golden standard to treat peripheral nerve lesions,especially lesions with large(≥3 cm)nerve gaps,is the use of a nerve autograft or reimplantation in cases where nerve root avulsions occur.If not tended early,degeneration of motor neurons and loss of axon regeneration can occur,leading to loss of function.Although surgical procedures exist,patients often do not fully recover,and quality of life deteriorates.Peripheral nerves have limited regeneration,and it is usually mediated by Schwann cells and neurotrophic factors,like glial cell line-derived neurotrophic factor,as seen in Wallerian degeneration.Glial cell line-derived neurotrophic factor is a neurotrophic factor known to promote motor neuron survival and neurite outgrowth.Glial cell line-derived neurotrophic factor is upregulated in different forms of nerve injuries like axotomy,sciatic nerve crush,and compression,thus creating great interest to explore this protein as a potential treatment for peripheral nerve injuries.Exogenous glial cell line-derived neurotrophic factor has shown positive effects in regeneration and functional recovery when applied in experimental models of peripheral nerve injuries.In this review,we discuss the mechanism of repair provided by Schwann cells and upregulation of glial cell line-derived neurotrophic factor,the latest findings on the effects of glial cell line-derived neurotrophic factor in different types of peripheral nerve injuries,delivery systems,and complementary treatments(electrical muscle stimulation and exercise).Understanding and overcoming the challenges of proper timing and glial cell line-derived neurotrophic factor delivery is paramount to creating novel treatments to tend to peripheral nerve injuries to improve patients'quality of life.
文摘One of the crucial and challenging issues for researchers is presenting an appropriate approach to evaluate the aerodynamic characteristics of air cushion vehicles(ACVs)in terms of system design parameters.One of these issues includes introducing a suitable approach to analyze the effect of geometric shapes on the aerodynamic characteristics of ACVs.The main novelty of this paper lies in presenting an innovative method to study the geometric shape effect on air cushion lift force,which has not been investigated thus far.Moreover,this paper introduces a new approximate mathematical formula for calculating the air cushion lift force in terms of parameters,including the air gap,lateral gaps,air inlet velocity,and scaling factor for the first time.Thus,we calculate the aerodynamic lift force applied to nine different shapes of the air cushions used in the ACVs in the present paper through the ANSYS Fluent software.The geometrical shapes studied in this paper are rectangular,square,equilateral triangle,circular,elliptic shapes,and four other combined shapes,including circle-rectangle,circle-square,hexagonal,and fillet square.Results showed that the cushion with a circular pattern produces the highest lift force among other geometric shapes with the same conditions.The increase in the cushion lift force can be attributed to the fillet with a square shape and its increasing radius compared with the square shape.
