Background:The aortic arch replacement and cardiopulmonary bypass(CPB)are both associated with the early mortality after cardiothoracic surgery.This study aimed to investigate the relationship between CPB time and 90-...Background:The aortic arch replacement and cardiopulmonary bypass(CPB)are both associated with the early mortality after cardiothoracic surgery.This study aimed to investigate the relationship between CPB time and 90-day post-operative mortality in patients undergoing aortic arch surgery using the frozen elephant trunk(FET)technique with selective ante-grade cerebral perfusion(SACP).Methods:We retrospectively reviewed data of 377 adult patients undergoing aortic arch surgery via FET with SACP from July 1,2017 to December 31,2018 at Beijing Anzhen Hospital.The baseline characteristics,intra-operative data,and post-operative data were collected.Univariate and multivariate Cox regression analyses were used to determine independent predictors of 90-day postoperative mortality.Results:The 90-day post-operative mortality was 13.53%.The 78.51%of patients were men.There were 318(84.35%)type A aortic dissections and 28(7.43%)aortic aneurysms.Among those,264(70.03%)were emergency operations.Median CPB time was 202.0(176.0,227.0)min.Multivariate Cox regression analysis revealed that CPB time was independently associated with 90-day post-operative mortality after adjusting confounding factors(hazard ratio:1.21/10 min increase in CPB time,95%confidence interval:1.15–1.27,P<0.001).Kaplan-Meier analysis based on CPB time tertiles revealed that the top tertile(median 236.0 min)was associated with reduced survival rate compared with middle and bottom tertiles(P<0.001).Each sub-group analysis based on the complexity of the underlying disease process showed similar associations between CPB time and 90-day post-operative mortality.Conclusions:CPB time remains a significant factor in determining 90-day post-operative mortality in patients undergoing aortic arch surgery using FET with SACP.Surgeons should be aware of the relationship between CPB time and 90-day post-operative mortality during operative procedures and avoid extended CPB time as far as possible.展开更多
抗冻肽是一类通过抑制冰晶生长使生物有机体免受冰冻伤害的多肽。文中采用酶法制备了高热滞活性的胶原抗冻肽,并考察了该抗冻肽对冷冻面团酵母存活率、发酵时间、馒头比容、质构及感官评分的影响。结果表明:胶原抗冻肽显著改善了冷冻面...抗冻肽是一类通过抑制冰晶生长使生物有机体免受冰冻伤害的多肽。文中采用酶法制备了高热滞活性的胶原抗冻肽,并考察了该抗冻肽对冷冻面团酵母存活率、发酵时间、馒头比容、质构及感官评分的影响。结果表明:胶原抗冻肽显著改善了冷冻面团的品质,当其添加量为0.3%时,面团经21 d冻藏后,酵母存活率从43%增加到54.5%;醒发时间缩短了33.3%,为60 min;馒头比容从1.74 m L/g增加到2.11 m L/g,上升了27.1%;馒头的硬度和咀嚼性显著减小,其回弹性、黏性、弹性均增加;同时冷冻面团的外观较好,感官总分达到55.5分。展开更多
文摘Background:The aortic arch replacement and cardiopulmonary bypass(CPB)are both associated with the early mortality after cardiothoracic surgery.This study aimed to investigate the relationship between CPB time and 90-day post-operative mortality in patients undergoing aortic arch surgery using the frozen elephant trunk(FET)technique with selective ante-grade cerebral perfusion(SACP).Methods:We retrospectively reviewed data of 377 adult patients undergoing aortic arch surgery via FET with SACP from July 1,2017 to December 31,2018 at Beijing Anzhen Hospital.The baseline characteristics,intra-operative data,and post-operative data were collected.Univariate and multivariate Cox regression analyses were used to determine independent predictors of 90-day postoperative mortality.Results:The 90-day post-operative mortality was 13.53%.The 78.51%of patients were men.There were 318(84.35%)type A aortic dissections and 28(7.43%)aortic aneurysms.Among those,264(70.03%)were emergency operations.Median CPB time was 202.0(176.0,227.0)min.Multivariate Cox regression analysis revealed that CPB time was independently associated with 90-day post-operative mortality after adjusting confounding factors(hazard ratio:1.21/10 min increase in CPB time,95%confidence interval:1.15–1.27,P<0.001).Kaplan-Meier analysis based on CPB time tertiles revealed that the top tertile(median 236.0 min)was associated with reduced survival rate compared with middle and bottom tertiles(P<0.001).Each sub-group analysis based on the complexity of the underlying disease process showed similar associations between CPB time and 90-day post-operative mortality.Conclusions:CPB time remains a significant factor in determining 90-day post-operative mortality in patients undergoing aortic arch surgery using FET with SACP.Surgeons should be aware of the relationship between CPB time and 90-day post-operative mortality during operative procedures and avoid extended CPB time as far as possible.
文摘抗冻肽是一类通过抑制冰晶生长使生物有机体免受冰冻伤害的多肽。文中采用酶法制备了高热滞活性的胶原抗冻肽,并考察了该抗冻肽对冷冻面团酵母存活率、发酵时间、馒头比容、质构及感官评分的影响。结果表明:胶原抗冻肽显著改善了冷冻面团的品质,当其添加量为0.3%时,面团经21 d冻藏后,酵母存活率从43%增加到54.5%;醒发时间缩短了33.3%,为60 min;馒头比容从1.74 m L/g增加到2.11 m L/g,上升了27.1%;馒头的硬度和咀嚼性显著减小,其回弹性、黏性、弹性均增加;同时冷冻面团的外观较好,感官总分达到55.5分。
