The effects of khat on the hormonal levels have been established;however, the effects on human beings are controversial. The aim of our study was to investigate the possible effects of khat on the levels of serum thyr...The effects of khat on the hormonal levels have been established;however, the effects on human beings are controversial. The aim of our study was to investigate the possible effects of khat on the levels of serum thyroid hormones, testosterone, estradiol (E2), prolactin and cortisol in men. A total of 50 blood samples were collected from healthy males who referred to chew khat for more than 10 years and analyzed for the above hormones. The results were compared to the hormonal levels of 35 non khat chewers. Chewing khat causes significant increases in the testosterone (P < 0.03), prolactin (P < 0.05), E2 (P < 0.00005), FT3 (P < 0.04), and TSH (P < 0.05) levels. No significant differences were found in the serum level of FT4 between the two groups. The level of cortisol were significantly lower (P < 0.001) in the khat chewers group compared to the control group. This study suggests that khat chewing can cause reduction in the cortisol level, which may cause increases of testosterone, prolactin and E2. In addition, chewing khat increases the level of TSH and FT3 serum levels. Therefore, khat may contribute to the relevant disorders caused by abnormal levels of the studied hormones in the people who are chewing展开更多
【目的】分析28~36周早产儿生后3~21 d FT3、FT4、TSH变化的特征。【方法】回顾性分析2018年7月至2019年6月中山大学附属第三医院新生儿科住院的236例28~36周早产儿的临床资料,包括甲状腺功能检查(FT3、FT4和TSH)、胎龄、性别、出生体...【目的】分析28~36周早产儿生后3~21 d FT3、FT4、TSH变化的特征。【方法】回顾性分析2018年7月至2019年6月中山大学附属第三医院新生儿科住院的236例28~36周早产儿的临床资料,包括甲状腺功能检查(FT3、FT4和TSH)、胎龄、性别、出生体质量、出生身长、检查日龄、辅助生殖方式、单胎或多胎、母亲甲状腺疾病和母亲妊娠期糖尿病,比较早产儿3~7 d与8~21 d FT3、FT4和TSH水平的差异;分析影响早产儿FT3、FT4和TSH水平的独立因素;比较不同胎龄早产儿FT3、FT4和TSH水平差异。【结果】早产儿3~7 d FT3水平(3.23±0.54)pmol/L,低于8~21 d的(3.41±0.76)pmol/L,差异有统计学意义(P=0.040);早产儿3~7 d的FT4水平(15.36±3.40)pmol/L,高于8~21 d的(13.20±2.63)pmol/L,差异有统计学意义(P<0.001);3~7 d与8~21 d的TSH分布的差异没有统计学意义(P=0.846);早产儿3~7 d FT3水平受到胎龄的影响(P<0.001),3~7天FT4水平受到胎龄和检查日龄的影响(P<0.001),8~21 d的FT3、FT4水平均受到胎龄和性别的影响(P<0.001、P<0.001);3~7 d、8~21 d的FT3、FT4水平与胎龄为正相关(P<0.001,P<0.001;P<0.001,P=0.001)。【结论】胎龄影响生后3~21 d早产儿的甲状腺功能,胎龄越小,FT3、FT4越低,需要建立一个胎龄相关的的FT4或T4参考范围,结合TSH联合评估甲状腺功能。展开更多
文摘The effects of khat on the hormonal levels have been established;however, the effects on human beings are controversial. The aim of our study was to investigate the possible effects of khat on the levels of serum thyroid hormones, testosterone, estradiol (E2), prolactin and cortisol in men. A total of 50 blood samples were collected from healthy males who referred to chew khat for more than 10 years and analyzed for the above hormones. The results were compared to the hormonal levels of 35 non khat chewers. Chewing khat causes significant increases in the testosterone (P < 0.03), prolactin (P < 0.05), E2 (P < 0.00005), FT3 (P < 0.04), and TSH (P < 0.05) levels. No significant differences were found in the serum level of FT4 between the two groups. The level of cortisol were significantly lower (P < 0.001) in the khat chewers group compared to the control group. This study suggests that khat chewing can cause reduction in the cortisol level, which may cause increases of testosterone, prolactin and E2. In addition, chewing khat increases the level of TSH and FT3 serum levels. Therefore, khat may contribute to the relevant disorders caused by abnormal levels of the studied hormones in the people who are chewing
文摘【目的】分析28~36周早产儿生后3~21 d FT3、FT4、TSH变化的特征。【方法】回顾性分析2018年7月至2019年6月中山大学附属第三医院新生儿科住院的236例28~36周早产儿的临床资料,包括甲状腺功能检查(FT3、FT4和TSH)、胎龄、性别、出生体质量、出生身长、检查日龄、辅助生殖方式、单胎或多胎、母亲甲状腺疾病和母亲妊娠期糖尿病,比较早产儿3~7 d与8~21 d FT3、FT4和TSH水平的差异;分析影响早产儿FT3、FT4和TSH水平的独立因素;比较不同胎龄早产儿FT3、FT4和TSH水平差异。【结果】早产儿3~7 d FT3水平(3.23±0.54)pmol/L,低于8~21 d的(3.41±0.76)pmol/L,差异有统计学意义(P=0.040);早产儿3~7 d的FT4水平(15.36±3.40)pmol/L,高于8~21 d的(13.20±2.63)pmol/L,差异有统计学意义(P<0.001);3~7 d与8~21 d的TSH分布的差异没有统计学意义(P=0.846);早产儿3~7 d FT3水平受到胎龄的影响(P<0.001),3~7天FT4水平受到胎龄和检查日龄的影响(P<0.001),8~21 d的FT3、FT4水平均受到胎龄和性别的影响(P<0.001、P<0.001);3~7 d、8~21 d的FT3、FT4水平与胎龄为正相关(P<0.001,P<0.001;P<0.001,P=0.001)。【结论】胎龄影响生后3~21 d早产儿的甲状腺功能,胎龄越小,FT3、FT4越低,需要建立一个胎龄相关的的FT4或T4参考范围,结合TSH联合评估甲状腺功能。
