摘要
目的研究乙醇对雄性大鼠甲状腺和肾上腺皮质功能的影响。方法给予雄性大鼠每天１５００ｍｇ／ｋｇ，３０００ｍｇ／ｋｇ和４０００ｍｇ／ｋｇ体重乙醇染毒连续７０天，并于染毒第３５天和７０天每组随机处死１０只，经腹主动脉采血，测定对照组及各剂量组血清ＦＴ３，ＦＴ４，ＴＳＨ和ＣＳ含量。结果染毒３５天各剂量组大鼠血清中ＦＴ３，ＦＴ４，ＴＳＨ和ＣＳ未发现有意义的改变；染毒７０天３０００ｍｇ／ｋｇ和４０００ｍｇ／ｋｇ组ＦＴ３含量较１５００ｍｇ／ｋｇ组下降，而４０００ｍｇ／ｋｇ组ＦＴ４含量较１５００ｍｇ／ｋｇ和３０００ｍｇ／ｋｇ组下降，差异均有显著性（Ｐ＜０．０５）；染毒７０天４０００ｍｇ／ｋｇ组ＣＳ含量较对照组升高，差异有显著性（Ｐ＜０．０５），且存在明显的剂量－效应关系。结论乙醇在一定程度上损害了大鼠甲状腺及肾上腺皮质的功能。
Objective To study the effect of alcohol on thyroid and adrenal gland cortex functions in male rats. Methods Male rats were gavaged daily with alcohol in dosages of 1 500 mg, 3 000 mg and 4 000 mg/kg.W for 70 days and 10 rats from each group were killed at random on 35th and 70th test day. The levels of FT3,FT4, TSH and CS in serum of the rats were determined. Results The levels of all indices of all groups didn't change significantly for 35 days. For 70 days, the levels of FT3 were significantly lower in 3 000 mg and 4 000 mg/kg.W groups than that in 1 500 mg/kg.W group, while the level of FT4 was significantly lower in 4 000 mg/kg.W group than those of 1 500 mg and 3 000 mg/kg.W groups (P<0.05). For 70 days, the level of CS was significantly higher in 4 000 mg/kg.W group compared with that of control group (P<0.05), and revealed a doseeffect relationship. Conclusion Alcohol can injure thyroid and adrenal gland cortex functions of male rats in some way.
出处
《沈阳医学院学报》
1999年第2期104-106,共3页
Journal of Shenyang Medical College
关键词
乙醇
雄性大鼠
甲状腺
肾上腺皮质
FT4
FT3
TSH
CS
alcohol
free triiodothyronine(FT3)
free tetraiodothyronine(FT4)
thyroidstimulating hormone(TSH)
cortisol(CS)
male rats
