Background Pulse wave velocity and flow-mediated vasodilation （FMD） are widely used as noninvasive modalities for evaluating atherosclerosis. However, it is not known whether pulse wave velocity is related to FMD in...Background Pulse wave velocity and flow-mediated vasodilation （FMD） are widely used as noninvasive modalities for evaluating atherosclerosis. However, it is not known whether pulse wave velocity is related to FMD in patients with coronary artery disease （CAD）. Therefore, the present study was designed to investigate the alteration in brachial-ankle pulse wave velocity （baPWV） and endothelial function in CAD patients. Methods Thirty-three patients with CAD and thirty control subjects were recruited for this study, baPWV was measured non-invasively using a VP 1000 automated PWV/ABI analyzer （PWV/ABI, Colin Co. Ltd., Komaki, Japan）. Endothelial function as reflected by FMD in the brachial artery was assessed with a high-resolution ultrasound device. Results baPWV was increased in CAD patients compared with control subjects [（1756.1±253.1） cm/s vs （1495.3±202.3） cm/s, P〈0.01]. FMD was significantly reduced in CAD patients compared with control subjects [（5.2±2.1） % vs （11.1±4.4） %, P〈0.01]. baPWV correlated with FMD （r =-0.68, P〈0.001）. The endothelium-independent vasodilation induced by sublingual nitroglycerin in the brachial artery was similar in the CAD group compared with the control group.Conclusions CAD is associated with increased baPWV and endothelial dysfunction. Increased baPWV parallels diminished endothelial function. Our data therefore suggest that baPWV can be used as a noninvasive surrogate index in clinical evaluation of endothelial function.展开更多
目的了解动脉硬度指数(ASI)能否检测动脉硬化早期与血管内皮功能的关系。方法用 YF-1血管硬度测量仪测量61例高血压病人的 ASI,并用高频超声测量其肱动脉血流介导的血管扩张反应(FMD)和硝酸甘油诱导的血管舒张功能(NID)。结果 ASI 与 F...目的了解动脉硬度指数(ASI)能否检测动脉硬化早期与血管内皮功能的关系。方法用 YF-1血管硬度测量仪测量61例高血压病人的 ASI,并用高频超声测量其肱动脉血流介导的血管扩张反应(FMD)和硝酸甘油诱导的血管舒张功能(NID)。结果 ASI 与 FMD 呈负相关:r=-0.340(P<0.01),ASI 中度升高组和重度升高组的 FMD 值低于正常组(P<0.05)。ASI 正常组、轻度升高组、中度升高组和重度升高组的 NID 差别不大(P>0.05)。结论 ASI 是一个早期发现动脉硬化的指标。展开更多
文摘Background Pulse wave velocity and flow-mediated vasodilation （FMD） are widely used as noninvasive modalities for evaluating atherosclerosis. However, it is not known whether pulse wave velocity is related to FMD in patients with coronary artery disease （CAD）. Therefore, the present study was designed to investigate the alteration in brachial-ankle pulse wave velocity （baPWV） and endothelial function in CAD patients. Methods Thirty-three patients with CAD and thirty control subjects were recruited for this study, baPWV was measured non-invasively using a VP 1000 automated PWV/ABI analyzer （PWV/ABI, Colin Co. Ltd., Komaki, Japan）. Endothelial function as reflected by FMD in the brachial artery was assessed with a high-resolution ultrasound device. Results baPWV was increased in CAD patients compared with control subjects [（1756.1±253.1） cm/s vs （1495.3±202.3） cm/s, P〈0.01]. FMD was significantly reduced in CAD patients compared with control subjects [（5.2±2.1） % vs （11.1±4.4） %, P〈0.01]. baPWV correlated with FMD （r =-0.68, P〈0.001）. The endothelium-independent vasodilation induced by sublingual nitroglycerin in the brachial artery was similar in the CAD group compared with the control group.Conclusions CAD is associated with increased baPWV and endothelial dysfunction. Increased baPWV parallels diminished endothelial function. Our data therefore suggest that baPWV can be used as a noninvasive surrogate index in clinical evaluation of endothelial function.
文摘目的了解动脉硬度指数(ASI)能否检测动脉硬化早期与血管内皮功能的关系。方法用 YF-1血管硬度测量仪测量61例高血压病人的 ASI,并用高频超声测量其肱动脉血流介导的血管扩张反应(FMD)和硝酸甘油诱导的血管舒张功能(NID)。结果 ASI 与 FMD 呈负相关:r=-0.340(P<0.01),ASI 中度升高组和重度升高组的 FMD 值低于正常组(P<0.05)。ASI 正常组、轻度升高组、中度升高组和重度升高组的 NID 差别不大(P>0.05)。结论 ASI 是一个早期发现动脉硬化的指标。
