One of the most frequently applied bioelectromagnetic effects is the deep heating of the living species with EMF energy. Despite its long history, hyperthermia is a rarely applied oncotherapy. The reason is its contro...One of the most frequently applied bioelectromagnetic effects is the deep heating of the living species with EMF energy. Despite its long history, hyperthermia is a rarely applied oncotherapy. The reason is its controversial results and complicated control. One of the solutions is concentrating the electromagnetic energy nanoscopically on the parts of the malignant cells instead of heating up the complete tumor-mass. This approach is a kind of non-uniform energy absorption, providing energy liberation only in the selected regions. The energy-absorption of the malignant cells targets the membranes and creates a situation far from thermal equilibrium. The selection of the malignant cells is based on their decided differences from their healthy counterparts. The distinguishing parameters are the electromagnetic properties of the components of the malignant tissue which are the physiologic differences between the malignant cells and their healthy counterparts. The targets realize nano-range heating, using natural nanoclusters on the cell-membrane without artificially implementing them. This energy absorption generates consequent reactions, like programmed cell-death (apoptosis) continued by immunogenic cell-death involving extended immune reactions.? The applied radiofrequency current is amplitude modulated by time-fractal modulation pattern. The accurately matched impedance realizes the self-selective mechanisms which are promoted by stochastic resonances. This complex method is a new kind of hyperthermia, named mEHT. Our objective is to analyze the problems of the selective, non-equilibrium energy absorption, and present a solution by the electromagnetic mechanisms for an effective and controllable hyperthermia in oncology.展开更多
The paper deals with the theoretical investigation of a fundamental problem of biomaguetic fluid flow through a porous medium subject to a magnetic field by using the principles of biomagnetic fluid dynamics （BFD）. ...The paper deals with the theoretical investigation of a fundamental problem of biomaguetic fluid flow through a porous medium subject to a magnetic field by using the principles of biomagnetic fluid dynamics （BFD）. The study pertains to a situation where magnetization of the fluid varies with temperature. The fluid is considered to be non-Newtonian, whose flow is governed by the equation of a second-grade viscoelastic fluid. The walls of the channel are assumed to be stretchable, where the surface velocity is proportional to the longitudinal distance from the origin of coordinates. The problem is first reduced to solving a system of coupled nonlinear differential equations involving seven parameters. Considering blood as a biomagnetic fluid and using the present analysis, an attempt is made to compute some parameters of the blood flow by developing a suitable numerical method and by devising an appropriate finite difference scheme. The computational results are presented in graphical form, and thereby some theoretical predictions are made with respect to the hemodynamical flow of the blood in a hyperthermal state under the action of a magnetic field. The results clearly indicate that the presence of a magnetic dipole bears the potential so as to affect the characteristics of the blood flow in arteries to a significant extent during the therapeutic procedure of electromagnetic hyperthermia. The study will attract the attention of clinicians, to whom the results would be useful in the treatment of cancer patients by the method of electromagnetic hyperthermia.展开更多
Hyperthermia is a treatment mechanism by which cancer cells can be damaged. In this mode of treatment, electromagnetic fields are used for increasing the temperature of malignant tissues at sufficiently high level for...Hyperthermia is a treatment mechanism by which cancer cells can be damaged. In this mode of treatment, electromagnetic fields are used for increasing the temperature of malignant tissues at sufficiently high level for destroying them. In this paper, major problems of hyperthermia and some proposed solutions are presented.展开更多
文摘One of the most frequently applied bioelectromagnetic effects is the deep heating of the living species with EMF energy. Despite its long history, hyperthermia is a rarely applied oncotherapy. The reason is its controversial results and complicated control. One of the solutions is concentrating the electromagnetic energy nanoscopically on the parts of the malignant cells instead of heating up the complete tumor-mass. This approach is a kind of non-uniform energy absorption, providing energy liberation only in the selected regions. The energy-absorption of the malignant cells targets the membranes and creates a situation far from thermal equilibrium. The selection of the malignant cells is based on their decided differences from their healthy counterparts. The distinguishing parameters are the electromagnetic properties of the components of the malignant tissue which are the physiologic differences between the malignant cells and their healthy counterparts. The targets realize nano-range heating, using natural nanoclusters on the cell-membrane without artificially implementing them. This energy absorption generates consequent reactions, like programmed cell-death (apoptosis) continued by immunogenic cell-death involving extended immune reactions.? The applied radiofrequency current is amplitude modulated by time-fractal modulation pattern. The accurately matched impedance realizes the self-selective mechanisms which are promoted by stochastic resonances. This complex method is a new kind of hyperthermia, named mEHT. Our objective is to analyze the problems of the selective, non-equilibrium energy absorption, and present a solution by the electromagnetic mechanisms for an effective and controllable hyperthermia in oncology.
文摘The paper deals with the theoretical investigation of a fundamental problem of biomaguetic fluid flow through a porous medium subject to a magnetic field by using the principles of biomagnetic fluid dynamics （BFD）. The study pertains to a situation where magnetization of the fluid varies with temperature. The fluid is considered to be non-Newtonian, whose flow is governed by the equation of a second-grade viscoelastic fluid. The walls of the channel are assumed to be stretchable, where the surface velocity is proportional to the longitudinal distance from the origin of coordinates. The problem is first reduced to solving a system of coupled nonlinear differential equations involving seven parameters. Considering blood as a biomagnetic fluid and using the present analysis, an attempt is made to compute some parameters of the blood flow by developing a suitable numerical method and by devising an appropriate finite difference scheme. The computational results are presented in graphical form, and thereby some theoretical predictions are made with respect to the hemodynamical flow of the blood in a hyperthermal state under the action of a magnetic field. The results clearly indicate that the presence of a magnetic dipole bears the potential so as to affect the characteristics of the blood flow in arteries to a significant extent during the therapeutic procedure of electromagnetic hyperthermia. The study will attract the attention of clinicians, to whom the results would be useful in the treatment of cancer patients by the method of electromagnetic hyperthermia.
文摘Hyperthermia is a treatment mechanism by which cancer cells can be damaged. In this mode of treatment, electromagnetic fields are used for increasing the temperature of malignant tissues at sufficiently high level for destroying them. In this paper, major problems of hyperthermia and some proposed solutions are presented.
