Trillions of microbes reside in the human body and participate in multiple physiological and pathophysiological processes that affect host health throughout the life cycle. The microbiome is hallmarked by distinctive ...Trillions of microbes reside in the human body and participate in multiple physiological and pathophysiological processes that affect host health throughout the life cycle. The microbiome is hallmarked by distinctive compositional and functional features across different life periods.Accumulating evidence has shown that microbes residing in the human body may play fundamental roles in infant development and the maturation of the immune system. Gut microbes are thought to be essential for the facilitation of infantile and childhood development and immunity by assisting in breaking down food substances to liberate nutrients, protecting against pathogens, stimulating or modulating the immune system, and exerting control over the hypothalamic–pituitary–adrenal axis.This review aims to summarize the current understanding of the colonization and development of the gut microbiota in early life, highlighting the recent findings regarding the role of intestinal microbes in pediatric diseases. Furthermore, we also discuss the microbiota-mediated therapeutics that can reconfigure bacterial communities to treat dysbiosis.展开更多
生命早期1000天(母亲怀孕到幼儿2周岁)是膳食营养影响一生健康的关键窗口期,成年期疾病的预防应从生命早期开始.出生队列研究是探讨多种暴露因素与不良妊娠结局及出生缺陷的关系、生命早期暴露对终身健康影响的优选方法.中国母婴营养健...生命早期1000天(母亲怀孕到幼儿2周岁)是膳食营养影响一生健康的关键窗口期,成年期疾病的预防应从生命早期开始.出生队列研究是探讨多种暴露因素与不良妊娠结局及出生缺陷的关系、生命早期暴露对终身健康影响的优选方法.中国母婴营养健康研究队列(China maternal and infant nutrition health cohort study, MINC)是国家母婴乳品健康工程技术研究中心启动的多地区健康母婴营养研究出生队列,重点研究早期膳食营养、喂养方式、生活习惯等与婴儿肠道菌群和近期、远期健康的相关性,探索成人非感染性疾病的早期营养干预预防措施,指导婴幼儿科学喂养.本文介绍了MINC背景、结构、研究目的及队列已入组人群、生物样本收集、母乳成分、肠道菌群等研究进展.展开更多
生命早期不良事件暴露,包括受精卵、胚胎、婴儿乃至儿童期,尤其生命早期1000天(宫内及出生后前2年)所暴露的宫内及外环境不良因素,可能对后代远期的健康和疾病风险产生影响,这一理论被称为健康与疾病的发育起源(the developmental origi...生命早期不良事件暴露,包括受精卵、胚胎、婴儿乃至儿童期,尤其生命早期1000天(宫内及出生后前2年)所暴露的宫内及外环境不良因素,可能对后代远期的健康和疾病风险产生影响,这一理论被称为健康与疾病的发育起源(the developmental origin of health and diseases,DOHaD)学说。如妊娠期营养过少或过多,孕妇高血糖未得到控制,环境内分泌干扰物(environmental endocrine disrupting chemicals,EEDCs)暴露均增加后代成年期慢性非传染性疾病如糖尿病、高血压及肥胖等发生率。展开更多
基金supported by the National Natural Science Foundation of China (Grant Nos. 81671504 and 81401248)the Sanming Project of Medicine in Shenzhen, China (Grant No. SZSM201606088)
文摘Trillions of microbes reside in the human body and participate in multiple physiological and pathophysiological processes that affect host health throughout the life cycle. The microbiome is hallmarked by distinctive compositional and functional features across different life periods.Accumulating evidence has shown that microbes residing in the human body may play fundamental roles in infant development and the maturation of the immune system. Gut microbes are thought to be essential for the facilitation of infantile and childhood development and immunity by assisting in breaking down food substances to liberate nutrients, protecting against pathogens, stimulating or modulating the immune system, and exerting control over the hypothalamic–pituitary–adrenal axis.This review aims to summarize the current understanding of the colonization and development of the gut microbiota in early life, highlighting the recent findings regarding the role of intestinal microbes in pediatric diseases. Furthermore, we also discuss the microbiota-mediated therapeutics that can reconfigure bacterial communities to treat dysbiosis.
文摘生命早期1000天(母亲怀孕到幼儿2周岁)是膳食营养影响一生健康的关键窗口期,成年期疾病的预防应从生命早期开始.出生队列研究是探讨多种暴露因素与不良妊娠结局及出生缺陷的关系、生命早期暴露对终身健康影响的优选方法.中国母婴营养健康研究队列(China maternal and infant nutrition health cohort study, MINC)是国家母婴乳品健康工程技术研究中心启动的多地区健康母婴营养研究出生队列,重点研究早期膳食营养、喂养方式、生活习惯等与婴儿肠道菌群和近期、远期健康的相关性,探索成人非感染性疾病的早期营养干预预防措施,指导婴幼儿科学喂养.本文介绍了MINC背景、结构、研究目的及队列已入组人群、生物样本收集、母乳成分、肠道菌群等研究进展.
文摘生命早期不良事件暴露,包括受精卵、胚胎、婴儿乃至儿童期,尤其生命早期1000天(宫内及出生后前2年)所暴露的宫内及外环境不良因素,可能对后代远期的健康和疾病风险产生影响,这一理论被称为健康与疾病的发育起源(the developmental origin of health and diseases,DOHaD)学说。如妊娠期营养过少或过多,孕妇高血糖未得到控制,环境内分泌干扰物(environmental endocrine disrupting chemicals,EEDCs)暴露均增加后代成年期慢性非传染性疾病如糖尿病、高血压及肥胖等发生率。
