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Intestinal Microbiota in Early Life and Its Implications on Childhood Health 被引量:20

Intestinal Microbiota in Early Life and Its Implications on Childhood Health
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摘要 Trillions of microbes reside in the human body and participate in multiple physiological and pathophysiological processes that affect host health throughout the life cycle. The microbiome is hallmarked by distinctive compositional and functional features across different life periods.Accumulating evidence has shown that microbes residing in the human body may play fundamental roles in infant development and the maturation of the immune system. Gut microbes are thought to be essential for the facilitation of infantile and childhood development and immunity by assisting in breaking down food substances to liberate nutrients, protecting against pathogens, stimulating or modulating the immune system, and exerting control over the hypothalamic–pituitary–adrenal axis.This review aims to summarize the current understanding of the colonization and development of the gut microbiota in early life, highlighting the recent findings regarding the role of intestinal microbes in pediatric diseases. Furthermore, we also discuss the microbiota-mediated therapeutics that can reconfigure bacterial communities to treat dysbiosis. Trillions of microbes reside in the human body and participate in multiple physiological and pathophysiological processes that affect host health throughout the life cycle. The microbiome is hallmarked by distinctive compositional and functional features across different life periods.Accumulating evidence has shown that microbes residing in the human body may play fundamental roles in infant development and the maturation of the immune system. Gut microbes are thought to be essential for the facilitation of infantile and childhood development and immunity by assisting in breaking down food substances to liberate nutrients, protecting against pathogens, stimulating or modulating the immune system, and exerting control over the hypothalamic–pituitary–adrenal axis.This review aims to summarize the current understanding of the colonization and development of the gut microbiota in early life, highlighting the recent findings regarding the role of intestinal microbes in pediatric diseases. Furthermore, we also discuss the microbiota-mediated therapeutics that can reconfigure bacterial communities to treat dysbiosis.
出处 《Genomics, Proteomics & Bioinformatics》 SCIE CAS CSCD 2019年第1期13-25,共13页 基因组蛋白质组与生物信息学报(英文版)
基金 supported by the National Natural Science Foundation of China (Grant Nos. 81671504 and 81401248) the Sanming Project of Medicine in Shenzhen, China (Grant No. SZSM201606088)
关键词 INTESTINAL MICROBIOTA IMMUNITY Gut-brain axis Early life Diseases MICROBIOTA manipulation Intestinal microbiota Immunity Gut–brain axis Early life Diseases Microbiota manipulation
分类号 Q [生物学]
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