The extraction of maximum power from the solar panels,using the sliding mode control scheme,becomes popular for partial weather atmospheric conditions due to its effective dynamic duty cycle ratio.However,the sliding ...The extraction of maximum power from the solar panels,using the sliding mode control scheme,becomes popular for partial weather atmospheric conditions due to its effective dynamic duty cycle ratio.However,the sliding mode control scheme was sophisticated with single integral and double integral sliding mode control scheme,which offer enhanced maximum power extraction and support enhanced solar panel efficiency in partial weather conditions.The operation of the sliding mode control scheme depends on the selection of a sliding surface selection based on the atmospheric weather condition,which enables the effective sliding duty cycle ratio operation for the DC/DC boost converter.The duty cycle ratio of the sliding mode control resembles the usual dynamic behavior to achieve enhanced efficiency compared to the various maximum power point tracking(MPPT)schemes.The major limitation of the sliding mode control scheme is to achieve the steady state voltage error of the solar panel in minimum settling time duration.The single integral sliding mode control scheme achieves the expected steady state voltage error limit but fails to achieve minimum settling time duration.Hence,the single integral sliding mode control is extended to a double integral sliding mode control scheme to achieve both steady state voltage error limits within the minimum settling time duration.This double integral sliding mode control scheme allows us to obtain the higher sliding surface duty cycle ratio which acts as the input signal to the boost converter.This activates the enhanced stable and reliable system operation,and nullifies the lacuna of maximum solar panel efficiency under partial weather conditions.Hence,this paper aims to present the design and performance operation of the double integral sliding mode(DISM)MPPT control scheme.To validate the performance analysis of the proposed DISM MPPT control scheme,the MATLAB/Simulink model is designed and verified.Also,the performance analysis of the proposed DISM MPPT control scheme is compared with展开更多
Due to the negative roles of tumor microenvironment(TME)in compromising therapeutic responses of various cancer therapies,it is expected that modulation of TME may be able to enhance the therapeutic responses during c...Due to the negative roles of tumor microenvironment(TME)in compromising therapeutic responses of various cancer therapies,it is expected that modulation of TME may be able to enhance the therapeutic responses during cancer treatment.Herein,we develop a concise strategy to prepare pH-responsive nanoparticles via the CaCO3-assisted double emulsion method,thereby enabling effective co-encapsulation of both doxorubicin(DOX),an immunogenic cell death(ICD)inducer,and alkylated NLG919(aNLG919),an inhibitor of indoleamine 2,3-dioxygenase 1(IDO1).The obtained DOX/aNLG919-loaded CaCO3 nanoparticles(DNCaNPs)are able to cause effective ICD of cancer cells and at the same time restrict the production of immunosuppressive kynurenine by inhibiting IDO1.Upon intravenous injection,such DNCaNPs show efficient tumor accumulation,improved tumor penetration of therapeutics and neutralization of acidic TME.As a result,those DNCaNPs can elicit effective anti-tumor immune responses featured in increased density of tumor-infiltrating CD8+cytotoxic T cells as well as depletion of immunosuppressive regulatory T cells(Tregs),thus effectively suppressing the growth of subcutaneous CT26 and orthotopic 4T1 tumors on the Balb/c mice through combined chemotherapy&immunotherapy.This study presents a compendious strategy for construction of pH-responsive nanoparticles,endowing significantly enhanced chemo-immunotherapy of cancer by overcoming the immunosuppressive TME.展开更多
An approach to generate high-speed and wideband frequency shift keying(FSK)signals based on carrier phase-shifted double sideband(CPS-DSB)modulation is proposed and experimentally validated.The core part of the scheme...An approach to generate high-speed and wideband frequency shift keying(FSK)signals based on carrier phase-shifted double sideband(CPS-DSB)modulation is proposed and experimentally validated.The core part of the scheme is a pair of cascaded polarization-sensitive LiNbO_(3) Mach–Zehnder modulators and phase modulators,whose polarization directions of the principal axes are mutually orthogonal to each other.A proof-of-concept experiment is carried out,where a 0.5 Gb/s FSK signal with the carrier frequencies of 4 and 8 GHz and a 1 Gb/s FSK signal with the carrier frequencies of 8 and 16 GHz are generated successfully.展开更多
文摘The extraction of maximum power from the solar panels,using the sliding mode control scheme,becomes popular for partial weather atmospheric conditions due to its effective dynamic duty cycle ratio.However,the sliding mode control scheme was sophisticated with single integral and double integral sliding mode control scheme,which offer enhanced maximum power extraction and support enhanced solar panel efficiency in partial weather conditions.The operation of the sliding mode control scheme depends on the selection of a sliding surface selection based on the atmospheric weather condition,which enables the effective sliding duty cycle ratio operation for the DC/DC boost converter.The duty cycle ratio of the sliding mode control resembles the usual dynamic behavior to achieve enhanced efficiency compared to the various maximum power point tracking(MPPT)schemes.The major limitation of the sliding mode control scheme is to achieve the steady state voltage error of the solar panel in minimum settling time duration.The single integral sliding mode control scheme achieves the expected steady state voltage error limit but fails to achieve minimum settling time duration.Hence,the single integral sliding mode control is extended to a double integral sliding mode control scheme to achieve both steady state voltage error limits within the minimum settling time duration.This double integral sliding mode control scheme allows us to obtain the higher sliding surface duty cycle ratio which acts as the input signal to the boost converter.This activates the enhanced stable and reliable system operation,and nullifies the lacuna of maximum solar panel efficiency under partial weather conditions.Hence,this paper aims to present the design and performance operation of the double integral sliding mode(DISM)MPPT control scheme.To validate the performance analysis of the proposed DISM MPPT control scheme,the MATLAB/Simulink model is designed and verified.Also,the performance analysis of the proposed DISM MPPT control scheme is compared with
基金partially supported by the National Natural Science Foundation of China(51802209,22077093,51761145041,51525203)the National Research Programs from Ministry of Science and Technology(MOST)of China(2016YFA0201200)+3 种基金the Natural Science Foundation of Jiangsu Province(BK20180848)the Jiangsu Social Development Project(BE2019658)Collaborative Innovation Center of Suzhou Nano Science and Technologythe 111 Program from the Ministry of Education of China.
文摘Due to the negative roles of tumor microenvironment(TME)in compromising therapeutic responses of various cancer therapies,it is expected that modulation of TME may be able to enhance the therapeutic responses during cancer treatment.Herein,we develop a concise strategy to prepare pH-responsive nanoparticles via the CaCO3-assisted double emulsion method,thereby enabling effective co-encapsulation of both doxorubicin(DOX),an immunogenic cell death(ICD)inducer,and alkylated NLG919(aNLG919),an inhibitor of indoleamine 2,3-dioxygenase 1(IDO1).The obtained DOX/aNLG919-loaded CaCO3 nanoparticles(DNCaNPs)are able to cause effective ICD of cancer cells and at the same time restrict the production of immunosuppressive kynurenine by inhibiting IDO1.Upon intravenous injection,such DNCaNPs show efficient tumor accumulation,improved tumor penetration of therapeutics and neutralization of acidic TME.As a result,those DNCaNPs can elicit effective anti-tumor immune responses featured in increased density of tumor-infiltrating CD8+cytotoxic T cells as well as depletion of immunosuppressive regulatory T cells(Tregs),thus effectively suppressing the growth of subcutaneous CT26 and orthotopic 4T1 tumors on the Balb/c mice through combined chemotherapy&immunotherapy.This study presents a compendious strategy for construction of pH-responsive nanoparticles,endowing significantly enhanced chemo-immunotherapy of cancer by overcoming the immunosuppressive TME.
基金supported by the National Natural Science Foundation of China(Nos.U2006217,61775015,61801017,and 61827818)。
文摘An approach to generate high-speed and wideband frequency shift keying(FSK)signals based on carrier phase-shifted double sideband(CPS-DSB)modulation is proposed and experimentally validated.The core part of the scheme is a pair of cascaded polarization-sensitive LiNbO_(3) Mach–Zehnder modulators and phase modulators,whose polarization directions of the principal axes are mutually orthogonal to each other.A proof-of-concept experiment is carried out,where a 0.5 Gb/s FSK signal with the carrier frequencies of 4 and 8 GHz and a 1 Gb/s FSK signal with the carrier frequencies of 8 and 16 GHz are generated successfully.
